1,424 research outputs found

    Notice relative aux travaux universitaires de Patricia Signorile

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    Patricia Signorile is a French philosopher whose work engages with reflections on art and culture through contemporary aesthetic and ethical questions. Her approach to the philosophy of art is distinguished by a particular focus on the relationships between art, ethics, and politics, as well as on how art can challenge our relationship to the world and to others within the context of contemporary and globalized societies.She offers a reflection on art as a transformative experience, particularly emphasizing the role of art in shaping our sensibilities, our aesthetic perception, and our engagement with social and political issues. For her, a work of art is not simply a representation of beauty or of an ideal sublime; it is a means of engagement, a critical act, and a form of reflection on human existence.Art as Aesthetic and Critical ExperienceFor Patricia Signorile, art is not limited to disinterested contemplation or a simple appreciation of beauty. On the contrary, she insists that art must be understood as an aesthetic experience that goes beyond individual emotions to engage in deeper reflection on the human condition and social issues. This aesthetic experience is, for her, critical: it does not aim merely to delight us, but to confront us with ethical and political problems.She bases her thinking on the notion of art as a means of questioning the world, of challenging social norms, and of bringing to light forms of injustice or violence that are invisible or ignored in society. In this way, art becomes a vehicle for social and personal transformation. This perspective aligns with a tradition of art as critical engagement, in the lineage of modern and contemporary artists who seek to provoke awareness in the viewer and to question established orders.Art and the Ethics of PerceptionOne of the central themes in her thought is the link between art and ethics, particularly through the notion of perception. Signorile is interested in how art can transform the way we perceive the world and others. She develops a reflection on the ethics of perception—a dimension that goes beyond mere aesthetic appreciation of a work of art to involve personal and social responsibility in how we receive and interpret artworks.From this perspective, art can be a tool for redefining the way we see and experience others, particularly marginalized or invisible groups in society.2025Patricia Signorile est une philosophe française dont le travail s'inscrit dans une réflexion sur l'art et la culture à travers des questions esthétiques et éthiques contemporaines. Son approche de la philosophie de l'art se distingue par une attention particulière aux relations entre l'art, l'éthique et la politique, ainsi qu'à la manière dont l'art peut interroger notre rapport au monde et à l'autre dans un contexte de sociétés contemporaines et mondialisées.Elle propose une réflexion sur l'art comme expérience transformative, et notamment sur le rôle de l'art dans la formation de nos sensibilités, de notre perception esthétique et de notre engagement dans des questions sociales et politiques. L'oeuvre d'art n'est pas pour elle simplement une représentation d'un beau ou d'un sublime idéal, mais un moyen d'engagement, un acte critique et une forme de réflexion sur l'existence humaine. L'art comme expérience esthétique et critique :Pour Patricia Signorile, l'art ne se limite pas à une contemplation désintéressée ou à une simple appréciation de la beauté. Au contraire, elle insiste sur le fait que l'art doit être perçu comme une expérience esthétique qui va au-delà des seules émotions individuelles pour toucher à une réflexion plus profonde sur la condition humaine et les enjeux sociaux. Cette expérience esthétique est pour elle critique : elle ne cherche pas simplement à nous émerveiller, mais à nous confronter à des problématiques éthiques et politiques.Elle se base sur la notion de l'art comme un moyen de questionner le monde, de remettre en cause les normes sociales, et de mettre en lumière des formes d'injustice ou de violence invisibles ou ignorées dans la société. Ainsi, l'art est un vecteur de transformation sociale et personnelle. Cela rejoint une tradition de l'art comme engagement critique, dans la lignée des artistes modernes et contemporains qui cherchent à provoquer une prise de conscience chez le spectateur et à remettre en cause les ordres établis. L'art et l'éthique de la perception :Un des axes importants de sa pensée est le lien entre art et éthique, notamment à travers la notion de perception. Signorile s'intéresse à la façon dont l'art peut transformer notre manière de percevoir le monde et l'autre. Elle développe une réflexion sur l'éthique de la perception, une dimension qui dépasse la simple appréciation esthétique de l'oeuvre d'art pour impliquer une responsabilité personnelle et sociale dans la manière dont nous accueillons et interprétons les oeuvres. Dans cette optique, l'art peut être un outil pour redéfinir la manière dont nous voyons et éprouvons les autres, particulièrement les groupes marginalisés ou invisibilisés dans la société.</div

    Letter from Claudio Signorile, the Italian Minister of Transportation, to Geraldine Ferraro

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    Letter from Claudio Signorile, the Italian Minister of Transportation, to Geraldine Ferraro. Letter includes a Library of Congress translation.https://ir.lawnet.fordham.edu/vice_presidential_campaign_correspondence_1984_international/1337/thumbnail.jp

    Notice relative aux travaux universitaires de Patricia Signorile

    No full text
    Patricia Signorile is a French philosopher whose work engages with reflections on art and culture through contemporary aesthetic and ethical questions. Her approach to the philosophy of art is distinguished by a particular focus on the relationships between art, ethics, and politics, as well as on how art can challenge our relationship to the world and to others within the context of contemporary and globalized societies.She offers a reflection on art as a transformative experience, particularly emphasizing the role of art in shaping our sensibilities, our aesthetic perception, and our engagement with social and political issues. For her, a work of art is not simply a representation of beauty or of an ideal sublime; it is a means of engagement, a critical act, and a form of reflection on human existence.Art as Aesthetic and Critical ExperienceFor Patricia Signorile, art is not limited to disinterested contemplation or a simple appreciation of beauty. On the contrary, she insists that art must be understood as an aesthetic experience that goes beyond individual emotions to engage in deeper reflection on the human condition and social issues. This aesthetic experience is, for her, critical: it does not aim merely to delight us, but to confront us with ethical and political problems.She bases her thinking on the notion of art as a means of questioning the world, of challenging social norms, and of bringing to light forms of injustice or violence that are invisible or ignored in society. In this way, art becomes a vehicle for social and personal transformation. This perspective aligns with a tradition of art as critical engagement, in the lineage of modern and contemporary artists who seek to provoke awareness in the viewer and to question established orders.Art and the Ethics of PerceptionOne of the central themes in her thought is the link between art and ethics, particularly through the notion of perception. Signorile is interested in how art can transform the way we perceive the world and others. She develops a reflection on the ethics of perception—a dimension that goes beyond mere aesthetic appreciation of a work of art to involve personal and social responsibility in how we receive and interpret artworks.From this perspective, art can be a tool for redefining the way we see and experience others, particularly marginalized or invisible groups in society.2025Patricia Signorile est une philosophe française dont le travail s'inscrit dans une réflexion sur l'art et la culture à travers des questions esthétiques et éthiques contemporaines. Son approche de la philosophie de l'art se distingue par une attention particulière aux relations entre l'art, l'éthique et la politique, ainsi qu'à la manière dont l'art peut interroger notre rapport au monde et à l'autre dans un contexte de sociétés contemporaines et mondialisées.Elle propose une réflexion sur l'art comme expérience transformative, et notamment sur le rôle de l'art dans la formation de nos sensibilités, de notre perception esthétique et de notre engagement dans des questions sociales et politiques. L'oeuvre d'art n'est pas pour elle simplement une représentation d'un beau ou d'un sublime idéal, mais un moyen d'engagement, un acte critique et une forme de réflexion sur l'existence humaine. L'art comme expérience esthétique et critique :Pour Patricia Signorile, l'art ne se limite pas à une contemplation désintéressée ou à une simple appréciation de la beauté. Au contraire, elle insiste sur le fait que l'art doit être perçu comme une expérience esthétique qui va au-delà des seules émotions individuelles pour toucher à une réflexion plus profonde sur la condition humaine et les enjeux sociaux. Cette expérience esthétique est pour elle critique : elle ne cherche pas simplement à nous émerveiller, mais à nous confronter à des problématiques éthiques et politiques.Elle se base sur la notion de l'art comme un moyen de questionner le monde, de remettre en cause les normes sociales, et de mettre en lumière des formes d'injustice ou de violence invisibles ou ignorées dans la société. Ainsi, l'art est un vecteur de transformation sociale et personnelle. Cela rejoint une tradition de l'art comme engagement critique, dans la lignée des artistes modernes et contemporains qui cherchent à provoquer une prise de conscience chez le spectateur et à remettre en cause les ordres établis. L'art et l'éthique de la perception :Un des axes importants de sa pensée est le lien entre art et éthique, notamment à travers la notion de perception. Signorile s'intéresse à la façon dont l'art peut transformer notre manière de percevoir le monde et l'autre. Elle développe une réflexion sur l'éthique de la perception, une dimension qui dépasse la simple appréciation esthétique de l'oeuvre d'art pour impliquer une responsabilité personnelle et sociale dans la manière dont nous accueillons et interprétons les oeuvres. Dans cette optique, l'art peut être un outil pour redéfinir la manière dont nous voyons et éprouvons les autres, particulièrement les groupes marginalisés ou invisibilisés dans la société.</div

    Supporting evidences for potential biomarkers of endometriosis detected in peripheral blood

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    AbstractIncidence of endometriosis is very high in women in the reproductive age (around 10%). To date, a reliable non-invasive diagnostic test for early diagnosis of endometriosis is not available. In this article we describe the potential value as diagnostic markers for endometriosis of two proteins (serum albumin and complement C3 precursor), previously identified as differentially expressed in women with endometriosis respect to healthy control by 2D gel analysis. A detailed description of the results obtained with this proteomic approach can be found in Signorile and Baldi [1]. ELISAs were performed on a large cohort of endometriosis (n=100) and healthy patients (n=10) to establish the differential expression of the identified proteins. ROC analyses confirmed the statistical significance of the differential expression of these proteins: serum albumin (p=0.028) ad complement C3 precursor (p=0.082). Evaluation of these two proteins, together with the already described Zn-alpha2-glycoprotein [1], could help in the early identification of endometriosis patient

    Aristocrazia signorile e città (secc. XI-XII)

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    Aristocrazia signorile e città (secc. XI-XII

    Chiese e cappelle dello spazio signorile

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    ITALIANO: Il saggio valuta l’esistenza di diritti di patronato esercitati sulle istituzioni ecclesiastiche dalle famiglie nobili trentine. Tra XIII e XIV secolo esistevano soprattutto diritti di avvocazia, dal significato essenzialmente patrimoniale, mentre nella maggior parte dei casi il dominio signorile non implicava l’esistenza di un diritto formale sulle chiese. Solo a partire dai decenni centrali del Quattrocento la documentazione permette di riconoscere più chiaramente l’esistenza di giuspatronati, che comportavano anche il diritto di presentare all’autorità ecclesiastica il candidato per il beneficio. / ENGLISH: The essay deals with the patronage rights that families of Trentino exercised above ecclesiastical institutions. Between 13th and 14th centuries the right of “advocacy” had essentially a patrimonial meaning; in most cases, the territorial power did not imply a formalized right over the churches. Only since the central decades of the 15th century does the documentation allow us to understand more about the existence of patronages, which also entailed the right to present the candidate for the benefice to the ecclesiastical authority

    Liberalitas estensis: le declinazioni del linguaggio politico in un dominio signorile

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    Attraverso l'analisi del caso di studio estense, l'articolo cerca di individuare i nessi generativi fra un aspetto concreto della politica signorile di governo - la liberalitas - e la propaganda signorile quattrocentesca

    Anti-mullerian hormone is expressed by endometriosis tissues and induces cell cycle arrest and apoptosis in endometriosis cells

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    Background: The anti-mullerian hormone (AMH) is a member of the transforming growth factor β (TGF-β) superfamily, which is responsible of the regression of the mullerian duct. AMH is expressed in the normal endometrium, where, acting in a paracrine fashion, negatively regulates cellular viability. Our objective was to evaluate the in vitro effects of the treatment with AMH of endometriosic cells. Methods. AMH expression in human endometriosis glands was evaluated by immunohistochemistry. RT-PCR has been used to quantify the expression levels of AMH and AMH RII isoforms, as well as of cytochrome P450 in both endometriosis epithelial and stromal cells Effects of AMH and AMH-cleaved treatment in endometriosis cells were evaluated by flow-cytometry analysis. Finally, it has been evaluated the effect of plasmin-digested AMH on cytochrome P450 activity. Results: AMH and AMH RII isoforms, as well as cytochrome P450, were expressed in both endometriosis epithelial and stromal cells. Treatment of endometriosis stromal and epithelial cell growth with AMH was able to induce a decrease in the percentage of cells in S phase and increase percentage of cells in G1 and G2 phase; coherently, decreased cell viability and increased percentage of cells death fraction was observed. The plasmin-digested AMH was able to suppress most of the cytochrome P450 activity, causing an increase of pre-G1 phase and of apoptosis induction treating with plasmin-digested AMH in both cell lines, most marked in the epithelial cells. Conclusions: The data produced suggest a possible use of AMH as therapeutic agents in endometriosis. © 2014 Signorile et al.; licensee BioMed Central Ltd
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