68 research outputs found
In reply to: A letter to the recent publication: Pericapsular nerve group (PENG) block provides improved short-term analgesia compared with the femoral nerve block in hip fracture surgery: a single-center double-blinded randomized comparative trial
No full textD-Yin Lin, Brigid Brown, Craig Morrison, Alex Saies, Reshma Pawar, Marthinus Vermeulen, Stewart Robert Anderson, Tsai Sheng Lee, Job Doornberg, Hidde Kroon, Ruurd Jaarsm
In reply to: 'towards precision regional anesthesia: is the PENG block appropriate for all hip fracture surgeries?'
No full textLetter to the EditorD-Yin Lin, Craig Morrison, Brigid Brown, Alex Saies, Reshma Pawar, Marthinus Vermeulen, Stewart Robert Anderson, Tsai Sheng Lee, Job Doornberg, Hidde Kroon, Ruurd Jaarsm
‘For what saies Quinapalus?’ Paper for Twelfth Night Seminar
No full textMark Houlahan ‘For what saies Quinapalus?’ John Manningham, the first person to report a performance of Twelfth Night (Feb 2, 1602), also began the discussion of the play’s sources. Scholars since then have linked the play to a network of sixteenth century plays and prose fictions in Italian, French and Latin. How much of these Shakespeare had read, seen or heard tell of we cannot say. This paper traces some (potential) threads from these sources, in particular those underpinning the flight of the twins and their arrival in Illyria. In several sources the disasters of war have dispersed the family. The play chooses not to directly represent this but the violence of war (by land and sea) erupts at key points in the action. When Viola and Sebastian finally meet in Act V they experience a combination of grief, trauma and relief. Two refugees finally arriving, alive, at a safe haven, is the emotional centre of the play; though in live performance and other adaptations this is often downplayed
Cutaneous nerve lesions of the shoulder and arm after arthroscopic shoulder surgery
No full textIncreasing use of shoulder arthroscopy has caused a developing awareness of the associated complications. A consecutive series of patients who had undergone arthroscopic surgery of the shoulder was reviewed. The overall incidence of a sensory deficit was 21 (7%) in 304 patients at 2 weeks after operation, and in approximately half (3.3%) of these patients this condition was still present at 8 month' average follow-up. These deficits fell into three distinct patterns, suggesting that damage was occurring to three different nerve branches. Most of these areas of hypesthesia corresponded to lesions of cutaneous branches of the axillary nerve; the most likely cause was direct injury at the portal sites, particularly the lateral portalHelen E. Segmuller, Samuel P. Alfred, Giorgina Zilio, Andrew D. Saies and Michael G. Hayeshttp://www.sciencedirect.com/science/journal/1058274
The use of patent databases by European small and medium-sized enterprises
No full textPatent databases contain a wealth of technical information, but only a fraction of innovative small and medium-sized enterprises (SAIEs) use them as an information source. The characteristics of SAIEs that use patent databases and the reasons why they do or do not use them are investigated in this study. Part of the analysis is based on the Community Innovation Survey results, which is the largest survey to date of innovative European firms. The results show that the probability of using patent databases increases with firm size and is higher among firms that perform research and development or which find patents of value as an appropriation method. Furthermore, the percentage of firms in each of 14 sectors that find patents to be an important information source is correlated with the patent propensity rale in each sector. The second part of the study is based on a combined survey and interview study of Dutch SAIEs in five high-technology sectors. The results show that SMEs mainly use patent databases to acquire information, often for legal purposes, that is not available from any other source. In contrast, these databases are seldom used to acquire technical data, largely because of the cost in terms of personnel time and expertise. This points to the need for simpler and more efficient methods of searching patent databases
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The use of patent databases by European small and medium-sized enterprises
No full textPatent databases contain a wealth of technical information, but only a fraction of innovative small and medium-sized enterprises (SAIEs) use them as an information source. The characteristics of SAIEs that use patent databases and the reasons why they do or do not use them are investigated in this study. Part of the analysis is based on the Community Innovation Survey results, which is the largest survey to date of innovative European firms. The results show that the probability of using patent databases increases with firm size and is higher among firms that perform research and development or which find patents of value as an appropriation method. Furthermore, the percentage of firms in each of 14 sectors that find patents to be an important information source is correlated with the patent propensity rale in each sector. The second part of the study is based on a combined survey and interview study of Dutch SAIEs in five high-technology sectors. The results show that SMEs mainly use patent databases to acquire information, often for legal purposes, that is not available from any other source. In contrast, these databases are seldom used to acquire technical data, largely because of the cost in terms of personnel time and expertise. This points to the need for simpler and more efficient methods of searching patent databases
Effects of intraduodenal lipid and protein on gut motility and hormone release, glycemia, appetite, and energy intake in lean men
No full textBACKGROUND: Intraduodenal lipid modulates gastrointestinal motility and hormone release and suppresses energy intake (EI) more than does intraduodenal glucose. Oral protein is the most satiating macronutrient and modulates postprandial glycemia; the comparative effects of intraduodenal protein and lipid and their combined effects are unclear. OBJECTIVE: We investigated the effects of intraduodenal protein and lipid, alone or in combination, on antropyloroduodenal motility, gastrointestinal hormone release, glycemia, and EI. DESIGN: Twenty lean men were studied on 5 randomized, double-blind occasions. Antropyloroduodenal motility, cholecystokinin, glucagon-like peptide-1 (GLP-1), insulin, glucagon, blood glucose, appetite, and nausea were measured during 90-min isocaloric (3 kcal/min) intraduodenal infusions of lipid [pure lipid condition (L3)], protein [pure protein condition (P3)], a 2:1 combination of lipid and protein [2:1 lipid:protein condition (L2P1)], a 1:2 combination of lipid and protein [1:2 lipid:protein condition (L1P2)], or a control. Immediately after the infusion, EI from a buffet lunch was quantified. RESULTS: In comparison with the control, all nutrient infusions suppressed antral and duodenal and stimulated pyloric pressures (P < 0.05). Cholecystokinin and GLP-1 release and pyloric stimulation were lipid-load dependent (r ≥ 0.39, P < 0.01), insulin and glucagon releases were protein-load dependent (r = 0.83, P < 0.001), and normoglycemia was maintained. L3 but not P3 increased nausea (P < 0.05). Compared with the control, L3 and P3 but not L2P1 or L1P2 suppressed EI (P < 0.05) without major effects on appetite. CONCLUSIONS: In lean men, despite differing effects on gut function, intraduodenal lipid and protein produce comparable reductions in energy intake. The effects of lipid may be a result of nausea. Protein also regulates blood glucose by stimulating insulin and glucagon. In contrast, at the loads selected, lipid:protein combinations did not suppress energy intake, suggesting that a threshold load is required to elicit effects. This trial was registered at Australia and New Zealand Clinical Trial Registry (http://www.anzctr.org.au) as 12609000949280.Amy T Ryan, Natalie D Luscombe-Marsh, Alexander A Saies, Tanya J Little, Scott Standfield, Michael Horowitz, and Christine Feinle-Bisse
A directed acyclic graph illustrating core instruments variable assumptions of the Mendelian randomization approach.
No full textIV assumption 1: IVs are strongly correlated with exposures. IV assumption 2: IVs are independent of outcomes (i.e., IVs can only affect outcomes through exposures). IV assumption 3: IVs are not related to confounding factors. IV: instrument variable; SAIEs: smoking and alcohol intake related exposures.</p
Pericapsular nerve group (PENG) block provides improved short-term analgesia compared with the femoral nerve block in hip fracture surgery: a single-center double-blinded randomized comparative trial
No full textPublished Online First 26 February 2021Background: The femoral nerve block (FNB) may be used for analgesia in hip fracture surgery. The pericapsular nerve group (PENG) block is a novel regional technique and may provide better pain reduction while preserving motor function, but these blocks have not been directly compared. Methods: In a single-center double-blinded randomized comparative trial, patients presenting for hip fracture surgery received analgesia with either FNB or PENG block. The primary outcome measure was pain scores (Numeric Rating Scale (NRS) 0 to 10). Secondary outcomes were postoperative quadriceps strength, opiate use, complications, length of hospital stay, and patient-reported outcomes. Results: Sixty patients were randomized and equally allocated between groups. Baseline demographics were similar. Postoperatively in recovery (day 0), the PENG group experienced less pain compared with the FNB group. (In the PENG group, 63% experienced no pain, 27% mild pain, and 10% moderate to severe pain. In comparison, 30% of the FNB group reported no pain, 27% mild pain, and 36% moderate to severe pain; p=0.04). This was assessed using an 11-point Likert NRS. Quadriceps strength was better preserved in the PENG group in the recovery unit (assessed using Oxford muscle strength grading, 60% intact in the PENG group vs none intact in the FNB group; p<0.001) and on day 1 (90% intact vs 50%, respectively; p=0.004). There was no difference in other outcomes. Conclusions: Patients receiving a PENG block for intraoperative and postoperative analgesia during hip fracture surgery experience less postoperative pain in the recovery room with no difference detected by postoperative day 1. Quadriceps strength was better preserved with the PENG block. Despite the short-term analgesic benefit and improved quadriceps strength, there were no differences detected in the quality of recovery.D-Yin Lin, Craig Morrison, Brigid Brown, Alexander Andrew Saies, Reshma Pawar, Marthinus Vermeulen, Stewart Robert Anderson, Tsai Sheng Lee, Job Doornberg, Hidde Maarten Kroon, Ruurd Lukas Jaarsm
On the Rebound: The implications of coping for starting a new firm after experiencing firm failure
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