1,722,328 research outputs found
Il trattamento dei difetti genetici ed acquisti di lipasi acida lisosomiale = The treatment of primary and secondary lysosomal acid lipase deficiency
Full text linkLysosomal acid lipase (LAL) is responsible for the hydrolysis of cholesteryl esters and triglycerides,
that reach the lysosomal compartment through the endocytosis of lipoproteins, or from the cytosol
through the autophagic process. When LAL activity is lacking, cholesteryl esters and triglycerides
accumulate in the body, causing severe pathologic manifestations, especially in the liver, spleen and
hematopoietic cells, in the presence of atherogenic dyslipidemia.
Two forms of genetic LAL deficiency (LAL-D) have been described: Wolman disease, the severe and
fulminant type, and cholesteryl ester storage disease, a milder and late form. In addition, acquired LAL-D
has been described in some pathologic conditions, as NAFLD and other advanced hepatopathies.
To date, a guideline for the management of genetic LAL-D is not available, but early diagnosis and treatment
is essential. Pharmacological management has been recently transformed by the availability of a
recombinant human LAL for enzyme replacement therapy, which has been shown effective and safe in
patients with genetic LAL-D. In addition, monitoring and management of associated complications is
indicated. Regarding acquired LAL-D, dedicated studies are needed to clarify the relationship between
LAL-D and NAFLD and, in particular, the possible prognostic role of LAL activity in NAFLD progression
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Occidente e mondo islamico dopo la Guerra fredda: breve storia di una relazione turbolenta
No full textAppropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Metaponto: ceramica a "pasta grigia"
No full textbreve panoramica delle presenze di ceramica "a pasta grigia" nel territorio metapontin
Ultrasound-guided interventional procedures of the liver during laparoscopy: technical considerations
No full textBackground: The increased application of laparoscopy to oncological cases has also expanded the applications of laparoscopic ultrasound (LUS). LUS-guided interventional procedures are often used for the staging of neoplastic disease. However, considerable expertise is required to perform the US-guided maneuvers. Methods: Based on our 7-year experience with laparoscopic ultrasound, we discuss a number of technical and practical aspects related to the performance of interventional procedures during LUS of the liver. Results: We performed 146 laparoscopic ultrasound exams in patients with neoplastic diseases. In all, 244 liver lesions were biopsied and 151 needle placements were made to perform radiofrequency ablation or ethanol injection. We discuss our choice of laparoscopic equipment and type of needle required (whether for biopsies or for interventional procedures). We also describe the technical characteristics of ultrasound probes and equipment, the correct approach to the patient, and the method that we employ to identify and then puncture the target lesion. Conclusion: The proper technique for interventional procedures during laparoscopic ultrasound can be mastered relatively quickly by a surgeon who is already familiar with traditional ultrasound techniques
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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