7,504 research outputs found

    'I thought this was a Christian thing?' Exploring virtuous and exclusionary cycles in faith-based social action

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    The role of faith groups as welfare providers has received notable attention in the past few years as religious groups have become increasingly active in the voluntary sector. Developing Baker's ideas on ‘local performative theologies’, we examine data from semi-structured interviews focusing on Christian interdenominational networks and forms of collaboration which underpin faith-based projects in a city in the South of England. Our particular focus is on the development of a qualitative understanding of city-wide interdenominational networks and their role in sustaining faith-based projects. We find that while there is a discernible shift towards faith through praxis, there has been insufficient attention to virtuous and exclusionary circuits of networks and collaboration which consolidate boundaries of inclusion and exclusion between faith groups

    Parmanu-Gunak

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    Parmanu-Gunak is a free Python based GUI application for reducing single and double spike isotope dilution data. Version 1.0 Please contact the author at [email protected] for any questions related to Parmanu-Gunak. If you use Parmanu-Gunak for your data reduction, then please cite the following paper: Pathak, D. (2023), Parmanu-Gunak: Data Reduction Software for Isotope Dilution Analysis. Geostand Geoanal Res. https://doi.org/10.1111/ggr.12476     </p

    Stoic beliefs and health: Development and preliminary validation of the Pathak-Wieten Stoicism Ideology Scale

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    © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. Introduction We developed and validated a new parsimonious scale to measure stoic beliefs. Key domains of stoicism are imperviousness to strong emotions, indifference to death, taciturnity and self-sufficiency. In the context of illness and disease, a personal ideology of stoicism may create an internal resistance to objective needs, which can lead to negative consequences. Stoicism has been linked to help-seeking delays, inadequate pain treatment, caregiver strain and suicide after economic stress. Methods During 2013-2014, 390 adults aged 18+ years completed a brief anonymous paper questionnaire containing the preliminary 24-item Pathak-Wieten Stoicism Ideology Scale (PW-SIS). Confirmatory factor analysis (CFA) was used to test an a priori multidomain theoretical model. Content validity and response distributions were examined. Sociodemographic predictors of strong endorsement of stoicism were explored with logistic regression. Results The final PW-SIS contains four conceptual domains and 12 items. CFA showed very good model fit: root mean square error of approximation (RMSEA)=0.05 (95% CI 0.04 to 0.07), goodness-of-fit index=0.96 and Tucker-Lewis Index=0.93. Cronbach's alpha was 0.78 and ranged from 0.64 to 0.71 for the subscales. Content validity analysis showed a statistically significant trend, with respondents who reported trying to be a stoic 'all of the time' having the highest PW-SIS scores. Men were over two times as likely as women to fall into the top quartile of responses (OR=2.30, 95% CI 1.44 to 3.68, P<0.001). ORs showing stronger endorsement of stoicism by Hispanics, Blacks and biracial persons were not statistically significant. Discussion The PW-SIS is a valid and theoretically coherent scale which is brief and practical for integration into a wide range of health behaviour and outcomes research studies

    A review of some UTD developments - past and present

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    A review of some early UTD developments following Keller's introduction of the GTD is described. That is followed bya description of more recent developments and future trends in UTD for solving problems of predicting the performance of antennas on complex metallic structures with thin material coating

    The interplay between cardiology and diabetology: a renewed collaboration to optimize cardiovascular prevention and heart failure management

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    Type 2 diabetes mellitus (T2DM) portends high risk of atherosclerotic cardiovascular (CV) events and of CV mortality; moreover, this group of patients has a very high probability of developing heart failure (HF). In this review, we discuss new advances in pharmacological treatment both in CV prevention and in HF management with a special focus on T2DM patients. A large number of randomized clinical trials and meta-analyses provided strong evidence about therapeutic strategies acting on glucose metabolism, such as GLP-1 RA and SGLT2i and about lipid-lowering treatment, such as PCSK9i and icosapent ethyl. Moreover, SGLT2i demonstrated strong evidence of benefit particularly in HF management both in diabetic and non-diabetic patients. The pathophysiological bases of multiple mechanisms of benefit of this class of drug explain the unexpected and remarkable results demonstrated both by prevention trials and by trials dedicated only to HF (like DAPA-HF). These, new drugs in the CV therapeutic armamentarium are establishing a new comprehensive approach from prevention to therapy of HF, giving more emphasis on HF classification in four stages (A→D). New therapies, which are on the horizon, promise to further reduce CV mortality and morbidity in HF patients irrespective of diabetic status

    Metagenome-based Screening Reveals Worldwide Distribution of LOV-Domain Proteins

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    Metagenomes from various environments were screened for sequences homologous to light, oxygen, voltage (LOV)-domain proteins. LOV domains are flavin binding, blue–light (BL)- sensitive photoreceptors present in 10–15% of deposited prokaryotic genomes. The LOV domain has been selected, since BL is an ever present and sometimes harmful environmental factor for microbial communities. The majority of the metagenome material originated from the Sargasso Sea Project and from open-ocean sampling. In total, more than 40 million open reading frames were investigated for LOV-domain sequences. Most sequences were identified from aquatic material, but they were also found in metagenomes from soil and extreme environments, e.g. hypersaline ponds, acidic mine drainage or wastewater treatment facilities. A total of 578 LOV domains was assigned by three criteria: (1) the highly conserved core region, (2) the presence of minimally 14 essential amino acids and (3) a minimal length of 80 amino acids. More than three quarters of these identified genes showed a sequence divergence of more than 20% from database-deposited LOV domains from known organisms, indicating the large variation of this photoreceptor motif. The broad occurrence of LOV domains in metagenomes emphasizes their important physiological role for light-induced signal transduction, stress adaptation and survival mechanisms
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