17 research outputs found
Long-term cosequences of intrahippocampal kainate injection in the Proechimys guyannensis rodent
No full textThe Proechimys guyannensis (PG), a spiny rodent specie living in the Amazonian region has been recently studied as an animal model of anti-convulsant mechanisms. the PG was found to be resistant to the administration of the muscarinic cholinergic agonist pilocarpine or the amygdala kindling development. This study examined the susceptibility of this animal species to the intrahippocampal kainic acid (KA) injection. Electrographic, behavioral and neuropathological changes induced by intrahippocampal KA injections were analyzed. PG showed to be extremely sensitive to the acute effects of the KA injection. Although the EEG findings in PG rodents were similar to those typically obtained in Wistar rats the pattern of electrographic activity in PG animals was longer than in Wistar rats. Neuropathological examinations of PG brains that survived KA-induced SE revealed severe cell loss in CA1/CA3 areas of the hippocampus, an extensive cell dispersion in the hilus of DG at the injected site with mossy fiber sprouting in the dentate gyrus supragranular layer. None of PG animals presented spontaneous seizures during the 120 days of observation. These findings confirm our previous observation on the resistance of this animal specie to experimental models of limbic epilepsy. (c) 2005 Elsevier B.V. All rights reserved.Universidade Federal de São Paulo, Disciplina Neurol Expt, BR-04023900 São Paulo, BrazilUniv Morgi Cruzes, Lab Neurociencias, NPT, São Paulo, BrazilUniversidade Federal de São Paulo, Disciplina Neurol Expt, BR-04023900 São Paulo, BrazilWeb of Scienc
"Carlo Roma 2020": architecture, city and politics in Carlo Aymonino's legacy
No full textL'articolo recensisce i lavori dell'omonimo convegno svoltosi a Roma e curato da Orazio Carpenzano e Federica Morgi
Analisi preliminare dei fattori demografici ed eziopatogenetici in pazienti affetti da carcinoma vescicale a medio rischio di recidiva
No full textRe-visiting the surgical role in treating chemotherapeutic-resistance pulmonary tuberculosis: Results from a systematic review and meta-analysis
No full textBackground: The incidence and prevalence of multi-drug-resistant and extensively drug-resistant pulmonary tuberculosis are increasing, posing profound health concerns; therefore, surgical intervention is gaining popularity again. However, the effectiveness of surgical treatment needs to be reassessed. This study attempted to determine the efficacy of surgical treatment and chemotherapy compared to chemotherapy alone among patients with pulmonary tuberculosis. Methods: A systematic search and meta-analysis were conducted from inception to June 2025 of the existing databases, including PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and Google Scholar. All double-arm studies available in English published between 2005 and August 2019 were included. Among 618 studies, 468 were selected based on abstract review. Eight out of 468 (8/468) studies were double-arm retrospective cohorts and observational studies, which included 1929 persons who matched the inclusion criteria. To measure the success of the surgical intervention, we used the pooled rate ratio, loss of patient follow-up, and the incidence of mortality using the random effects heterogeneity model. Results: Overall, there was no statistically significant difference in the treatment success rate (RR=1.24 (0.98–1.56), p = 0.07) and mortality rate (RR=1.82 (0.31–10.63, p = 0.51) between the two groups. Interestingly, the summary rate ratio (RR=0.41 (0.18–0.93), p = 0.03) showed that the surgical group had a considerably lower loss rate to follow-up than the non-surgical group. There was no evidence of heterogeneity amongst the trials (I2 =0 %, τ2 =0.00, df=2, p = 0.36). Conclusions: The current meta-analysis was the first to use a factor of loss of follow-up collected from several reports as a predictive tool to assess the effectiveness of surgical participation in treating drug-resistant tuberculosis patients. The rate of patient loss to follow-up in the surgical group suggested that the combination approach of surgery and chemotherapy showed a potential superiority over chemotherapy alone
A new Later Upper Palaeolithic open-air site with articulated horse bone in the Colne Valley, Berkshire
No full textThe end of the last Ice Age in Britain (c. 11500 BP) created major disruption to the biosphere. Open habitats were succeeded by more wooded landscapes, and changes occurred to the fauna following the abrupt disappearance of typical glacial herd species, such as reindeer and horse (Conneller & Higham 2015). Understanding the impact of these changes on humans and how quickly they were able to adapt may soon become clearer, due to recent discoveries in the Colne Valley on the western edge of Greater London, north of the River Thames. An exceptionally well-preserved open-air site was discovered in 2014 as part of a wider project of archaeological investigation and excavation carried out by Wessex Archaeology (2015), on behalf of CEMEX UK. The site, at Kingsmead Quarry in Horton, is unusual because it has good organic preservation and, in addition to worked flint artefacts, it has yielded groups of articulated horse bone. The extreme rarity of such sites of this period in Britain makes this discovery especially significant and re-emphasises the potential importance of the Colne Valley (Lacaille 1963; Lewis 2011; Morgi et al. 2011).</jats:p
Autorización del caballero Teodoro de Croix [comandante general de las Provincias Internas] pa-ra que Roque Medina pueda contraer matrimonio con María Encarnación Ortiz, vecina de
No full textAutorización del caballero Teodoro de Croix [comandante general de las Provincias Internas] pa-ra que Roque Medina pueda contraer matrimonio con María Encarnación Ortiz, vecina del pueblo de San José de Chinapa: Arizpe, 18 abril 1780. Segui-da de acta de bautizo de Roque Medina, originario de la villa de Silanes, arzobispado de Burgos [Espa-ña]: Villa de Silanes, 20 agosto 1736; certificación de libertad y soltería del mismo, suscrita por el bachiller Juan Grillo de Thena: Cuartel de Palencia, 5 junio 1764; solicitud que dirige Medina a Manuel Merino para que practique las diligencias que previene la ordenanza del Monte Pío Militar, en rela-ción a María Encarnación Ortiz, con quien tiene tratado matrimonio: Fronteras, 9 abril 1780; e in-formaciones de libertad y soltería de dicho Medina, hechas ante el notario Antonio Gerónimo Olivas; con certificación del capellán fray Juan Agustín Morgi: Arizpe, abril 1780
EMBANKMENT OF CHARTERED TOWN ŻYCHLIN
No full textPrawna lokacja miasta Żychlina nastąpiła prawdopodobnie w latach 1340-1348, a jego kształt przestrzenny
powstał w drugiej połowie XIV wieku. Obszar miasta o powierzchni około 7,5 morgi (4,1 ha)
tworzył owal otoczony obwałowaniami. Centralną częścią miasta był rynek o wymiarach 13x20 prętów
(około 56x86 m) otoczony blokami zabudowy mieszkalnej. Obwałowania miasta lokacyjnego, potwierdzone
w dokumentach historycznych, miały długość około 800 m oraz 4 bramy wjazdowe. Brak jest informacji
o wielkości nasypów ziemnych. Autor hipotetycznie przyjął, że ich kubatura mogła wynieść ponad
11 tys. m3 ziemi, piasku i żwiru. Tak duża objętość materiałów kopalnych użytych do usypania wałów zostawiła
ślad – wyrobisko w najbliższej okolicy miasta lokacyjnego tj. przy dawnej ul. Żabiej, obecnej Kościuszki,
na terenie współcześnie urządzonego Parku Miejskiego. Wały miejskie istniały prawdopodobnie
do połowy XVII wieku, tj. do czasu kiedy podjęto decyzję o powiększeniu rynku i budowy frontem do niego
murowanego kościoła p.w. św. Piotra i Pawła oraz wytyczeniu nowej ul. Łowickiej (ob. Narutowicza).Legal location of town Żychlin had taken place probably in years 1340 – 1348. It’s dimensional shape was
established in second half of XIV century. City area was about 7,5 acres (4,1 ha) and it created oval, surrounded
by embankment. Central city part was marketplace size of 13x20 poles (around 56x86 m) surrounded
by blocks of residential buildings. Embankment of chartered town, reassured in historical documents, had
length of approximately 800m and 4 entrance gates. There is no information about the size of earthen banks.
Author hypothetically assumed that its cubature was over 11 thousand cubic meters of earth, sand and gravel.
Such big volume of dug materials used to build the embankment left remnant – excavation in the nearest
surroundings of chartered town, beside Żabia street currently Kościuszki street, on territory of modern decorated
Town Park. Town embankment had existed probably until half of XVII century when the decision was
made to increase the marketplace size, building brick church dedicated to saint Peter and Paul and to demarcate
new Łowicka street (now Narutowicza)
Application of the point-stand method of the bird census in the managed forests
No full textThis paper presents the results of a bird census in the Morgi forest range in the Kolbuszowa Forest District (SE Poland). The census was conducted using the point−stand method, i.e. a modification of the point count. This modification enabled tailoring the method to the conditions of the Polish forestry, in which forest stand that is the basic unit of silviculture planning and forest management. The aim of the study was to test the new method of bird census in the managed and large−scale forest units, and to evaluate the utility of the results for conservation measures. Based on the list of stands of the Kolbuszowa Forest District, we drew randomly 270 forest stands, taking
into account their most important features: dominant species, forest habitat type, age and vertical structure. Bird counts were carried out in spring of 2014 and 2015. Each stand was inspected twice during each season: 1) between April and mid−May, and 2) between mid−May and the first decade of July. In total, 1080 observation (listening) sessions were conducted and each of the stands was inspected four times. As a result, 14 982 bird observations of 15 757 individuals belonging to 113 species were made. In case of 6720 observations, 7186 individuals belonging to 85 species were recorded in the studied stands. The point−stand bird census presented in the paper, which is a forest−range census type, is adequate for use in large−scale forest units. It allows to determine fauna indices that characterise the forest range, together with the most important features of stands
Umowy między dziedzicami a chłopami w zasobie Archiwum Państwowego w Łodzi (1807–1846)
No full textThe article presents the relations between peasants and landlords in the period between the issuing of the December Decree (1807) and the publication of the June Act (1846). The constitution of the Duchy of Warsaw granted peasants personal freedom and announced the introduction of the Napoleonic Civil Code, which was to abolish feudalism. However, the December Decree, which was issued shortly afterwards, determined that squires should be considered owners of peasant farms, and not the peasant working there, according to the new capitalist understanding. In 1846, the so-called June Act significantly limited the possibility of ousting peasants by squires as it restored the concept of dominium directum et utile for farms with at least three acres of land. The aim of the present paper is to answer the question to what extent the Napoleonic Code affected the relations between the squires and the peasantry. A detailed analysis of the five contracts concluded at that time which are in the State Archive in Łódź suggests that modern French law had very little impact on property relations in the Polish countryside. In fact, the contracts between squires and peasants resulted in legal arrangements described as dominium directum et utile, although this institution was not even mentioned in the Napoleonic Code.Artykuł dotyczy relacji między chłopami a dziedzicami w okresie między wydaniem dekretu grudniowego (1807) a ogłoszeniem ukazu czerwcowego (1846). Konstytucja Księstwa Warszawskiego przyznała chłopom wolność osobistą i zapowiedziała wprowadzenie zrywającego z feudalizmem napoleońskiego kodeksu cywilnego, ale wydany wkrótce po niej dekret grudniowy przesądził, że za właścicieli gospodarstw chłopskich w nowym kapitalistycznym rozumieniu należy co do zasady uznawać dziedziców, a nie chłopów. Z kolei wydany w 1846 r. tzw. ukaz czerwcowy istotnie ograniczał możliwość rugowania chłopów przez właścicieli ziemskich, przywracając w odniesieniu do gospodarstw obejmujących co najmniej trzy morgi gruntu stan prawny, który można określić mianem własności podzielonej. Celem artykułu jest próba odpowiedzi na pytanie, w jakim stopniu Kodeks Napoleona wpłynął na kształt stosunków między dworami a chłopami. Drobiazgowa analiza pięciu zawartych w tym okresie umów znajdujących się obecnie w zasobie Archiwum Państwowego w Łodzi sugeruje, że nowoczesne francuskie prawo w bardzo niewielkim stopniu oddziaływało na stosunki własnościowe na polskiej wsi. Mocą zawieranych umów tworzono prawa rzeczowe, które można określić mianem własności podzielonej – mimo że instytucja ta została pominięta przez twórców Kodeksu Napoleona
Extent of pathogenic and spoilage microorganisms in whole muscle meat, meat products and seafood sold in Libyan market
No full textBackground: Whole muscle meat, meat products, and seafood contain different nutrients in adequate quantity providing a better environment for presence and replication of different microorganisms. There are underreporting and inaccurate estimation of foodborne diseases due to the lack of effective surveillance systems in Libya.
Aim: To determine the extent of microbiological contamination of whole muscle meat, meat products and seafood.
Methods: A total number of 731 samples of retail meat were collected from different stores in four cities in Libya. Samples were analyzed for aerobic plate count (APC), and subjected to microbiological enumeration and isolation techniques, followed by molecular identification by PCR and partially sequencing of 16S rDNA.
Results: The results showed contamination of samples with enteric and spoilage bacteria. Fifteen genera of spoilage bacteria yielded 149 isolates were detected and identified by PCR and partially sequencing of 16S rDNA as: Proteus spp., Provedencia spp., Raouttella ornithinolytical, Citrobacter spp., Enterobacter spp., Morganella morgi, Shewanella algea, Rhodobacter capsulatus, Listonella pelagia, Kluyvera spp., Pectobacterium spp., Brenneria spp., Klebsiella spp., Acintobacter radioresistens, and Pantoea spp. While for pathogenic bacteria, 143 isolates distributed among nine genera were identified by PCR and partially sequencing of 16S rDNA as: Bacillus spp., Escherichia spp., Shigella spp., Enterococci spp., Cronobacter spp., Staphylococci spp., Salmonella spp., Aeromonas spp., and Vibrio spp.. Many isolated bacteria are zoonotic bacteria with high importance for public health.
Conclusion: Excessive handling and processing of meat and meat products seems to be one of the poorest microbiological quality. These findings ought to be helpful in risk assessments and quality assurance of meat in order to improve food safety
