104 research outputs found
Comportamento a lungo termine di strutture ibride contenenti elementi prefabbricati in calcestruzzo
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An open-label study on the short-term effects of a novel EFSA-compliant nutraceutical combination in mild-to-moderate hypercholesterolemia
No full textOBJECTIVE: Recently, the European Food Safety Authority (EFSA) has recommended to limit the use of total monacolins in red yeast rice (RYR) products to a dose <3 mg/day. However, data concerning the lipid lowering efficacy of the reduced dosage remain limited. A monacolin dose reduced due to safety issues may be expected to be less effective as a lipid lowering strategy and, for this reason, nutraceutical combinations with other active compounds may offer a viable solution as they can act synergistically through different mechanisms. MATERIALS AND METHODS: This 8-week open-label study was designed to investigate the safety and efficacy of a novel ESFA-compliant lipid lowering nutraceutical combination (Colestarmony Plus(®); containing total monacolins from RYR at a dose of 2.9 mg/day, a highly bioavailable berberine formulation, and pomegranate extract) in subjects (n=40) with mild-to-moderate hypercholesterolemia and no history of cardiovascular disease. RESULTS: After 8 weeks of supplementation, Colestarmony Plus(® )significantly reduced total cholesterol (−10.4%, p<0.05), low-density lipoprotein cholesterol (−14.8%, p<0.05), oxidized low-density lipoprotein cholesterol (−12.0%, p<0.05), and high-sensitivity C-reactive protein (−14.0%, p<0.05) compared with baseline values. A subgroup of 22 patients underwent measurements of flow-mediated dilation, with values increasing by 18.0% at 8 weeks with respect to baseline (p<0.05). The supplement was generally well-tolerated. CONCLUSION: Our short-term results indicate that the tested ESFA-compliant nutraceutical is effective in a primary prevention setting, even by providing only <3 mg/day of monacolins
Effects of a nutraceutical combination of fermented red rice, liposomal berberine, and curcumin on lipid and inflammatory parameters in patients with mild-to-moderate hypercholesterolemia: an 8-week, open-label, single-arm pilot study
No full textThe present open-label, single-arm pilot study sought to evaluate the effects of a nutraceutical combination containing fermented red rice, liposomal berberine, and curcumin on lipid and inflammatory parameters in patients with mild-to-moderate hypercholesterolemia
[Ozone therapy: a potential adjunct approach to lower urinary tract infection? A case series report]
No full textMulti-resistant drug bacteria are an emerging health care concern around the world. A decreased resistance to infection as seen in Chronic Kidney Disease (CKD) and kidney transplanted patients as well as some metabolic abnormalities such as hyperglycemia and glycosuria or clinical conditions such as the neurogenic bladder may indeed portend a great risk of recurrent urinary tract infections (UTI). The common and indiscriminate use of antibiotics often provides the patients with only a transient or partial amelioration of the urinary tract discomforts and increases the risk of multi-resistant drug bacteria selection. Thus a great effort is made in order to develop new antibacterial approaches especially in the setting of multi- antibiotic resistant pathogens. We herein report on some promising yet preliminary results of the use of ozone therapy in UTI
Relationship between apolipoprotein(a) size polymorphism and coronary heart disease in overweight subjects
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A preliminary investigation for accidental load design of a submerged floating tube bridges
No full textSubmerged floating tunnels are more and more considered as a suitable solution to cross water channels limiting environmental impact on the visual landscape and ensuring large ship passage while crossing large distances between coasts. The design of this kind of strategical infrastructures must deal not only with live loads and particular loading conditions coming from the floating situation, but needs also to carefully consider accidental actions that concur to the global safety of the infrastructure. The construction of the new E39 highway along the Norwegian coast asks for crossing several fjords and this solution is seriously taken into consideration. For this reason, a comprehensive research program was aimed at the analysis of accidental load design of the infrastructure. This paper aims to present a comprehensive overview of an ad-hoc experimental investigation on the behavior of reinforced concrete (RC) circular slabs (60 cm diameter) under exposure to fire, blast, or a combination of both actions. Additionally, it seeks to draw design-driven conclusions that could be valuable for the design of critical infrastructure in scenarios involving fire and blast. The presented experimental campaign was intended to provide a benchmark for assessing the reliability of the design approaches to be adopted in the design of the global infrastructure. First of all, the concrete mechanical characterization at normal conditions and at high temperatures was performed referring both to uniaxial compression and uniaxial tension. The structural behavior of simply supported RC slabs has also been investigated by considering slabs exposed to a hydrocarbon fire curve at different exposure times and by considering the post-fire application of static or dynamic loading condition. In particular, the fire curve was applied by a gas burner while the dynamic load was reproduced by a shock tube equipment that was used to apply two different blast-like pressure histories
Coronary spasm and acute myocardial infarction due to a mutation (V734I) in the nucleotide binding domain 1 of ABCC9
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