675 research outputs found
Compte rendu de Peters (A.), Devers (M.), Thevenot-Werner (A.-M.), Zbinden (P.) (dir.). Les acteurs à l’heure du constitutionnalisme Global.
No full textPeters (A.), Devers (M.), Thevenot-Werner (A.-M.), Zbinden (P.) (dir.). Les acteurs à l’heure du constitutionnalisme Global.", Paris : Société de législation comparée, 2014, 200 p., ISBN : 9782365170314
Factors associated with hypotension and bradycardia after extradural block
No full textIn order to identify patient-, anesthesia-, and surgery-related factors influencing the probability of hypotension and bradycardia after epidural blockade, an observational study was conducted on 1050 nonpregnant patients. Backward stepwise logistic regression was performed on the variables hypotension (systolic blood pressure <90 mm Hg) and bradycardia (heart rate <or=to45 bpm). Hypotension and bradycardia occurred in 158 and 24 patients, respectively. The probability of hypotension increased when epidural fentanyl was administered (odds ratio [OR] = 2.18; 95% confidence interval [CI] = 1.16-4.11), with body weight and spread of epidural analgesia, and decreased when a tourniquet was used (OR = 0.01, CI = 0.01-0.02) and bupivacaine instead of carbonated lidocaine was administered (OR = 0.28, CI = 0.14-0.60). Sensitivity and specificity of the model were 89% and 88%, respectively. The probability of bradycardia was less in women (OR = 0.05, CI = 0.01-0.41) and when a tourniquet was used (OR = 0.04, CI = 0.02-0.09). Sensitivity and specificity were 50% and 97%, respectively. In conclusion, our analysis can contribute to identification of patients at high risk to develop hypotension and bradycardia after epidural blockade. If bupivacaine instead of carbonated lidocaine is used and epidural fentanyl is not administered a decrease in the incidence of hypotension may be anticipated
A Multifactorial approach to explain inadequate surgical analgesia following extradural blockade
No full textEpidural Fentanyl, Epinephrine and Clonidine as adjuvants to local anesthetics for surgical analgesia: meta-analysis of analgesia and side-effects
No full textModelling Induced Seismicity with a Hydraulic-Mechanical-Stochastic Simulator: Review of Case Studies.
No full textWhite River Fish Hybridization
No full textData repository for:
Zbinden, Z. D., Douglas, M. R., Chafin, T. K., & Douglas, M. E. (2023). A community genomics approach to natural hybridization. Proceedings of the Royal Society B, 290(1999), 20230768. https://doi.org/10.1098/rspb.2023.0768
A Direct search procedure to optimize combinations of epidural Bupivacaine, Fentanyl and Clonidine for postoperative analgesia
No full textWhite River Fish Genetic Structure
No full textData repository for:
Zbinden, Z. D., Douglas, M. R., Chafin, T. K., & Douglas, M. E. (2023). Riverscape community genomics: A comparative analytical approach to identify common drivers of spatial structure. Molecular Ecology, 32(24), 6743-6765. https://doi.org/10.1111/mec.1680
Cardiovascular risk factors impair native collateral development and may impair efficacy of therapeutic interventions
No full textAnimal and early clinical studies of gene therapy for tissue ischaemia suggested that this approach might provide benefit to patients with coronary artery disease not amenable to traditional revascularization. This enthusiasm was then tempered by the subsequent disappointing results of randomized clinical trials and led researchers to develop strategies using progenitor cells as an alternative to improve collateral function. However, the recent publication of several randomized clinical trials reporting either negative or weakly positive results using this approach have led to questions regarding its effectiveness. There are several factors that need to be considered in explaining the discordance between the positive studies of such treatments in animals and the disappointing results seen in randomized patient trials. Aside from the practical issues of arteriogenic therapies, such as effective delivery, vascular remodelling is an extraordinarily complex process, and the administration of a single agent or cell in the hope that it would lead to lasting physiological effects may be far too simplistic an approach. In addition, however, evidence now suggests that many of the traditional cardiovascular risk factors-such as age and hypercholesterolemia-may impair the host response not only to ischaemia but, critically, also to treatment as well. This review discusses the evidence and mechanisms for these observations and highlights future directions that might be taken in an effort to provide more effective therapies
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