1,720,996 research outputs found
Specific local immunotherapy with macronized dust in the treatment of seasonal allergic rhinopathy caused by graminacee.
No full textThe behaviour of non-specific nasal provocation tests in subjects with allergic rhinitis and not, in and out of crisis. A longitudinal study
No full textThe non specific nasal hypersensitivity (N.S.N.H.) is characterized by an exaggerated reaction towards various non-specific stimuli in rhinopatic subjects. This N.S.N.H. involves the afferent structure of nasal mucosa, the effector organ and the central modulation system. The physiopathogenetic and clinics implications induced the authors to study the N.S.N.H. behaviour in 218 subjects divided into 5 groups, as follows: control group, subjects with perennial rhinitis of non allergic origin, subjects with seasonal rhinitis due to allergy towards Graminacee during seasonal crisis and not, subjects with perennial rhinitis due to allergy towards Dermatophagoides Pteronissinus. All subjects moreover have been subdivided according to the years of illness. The N.S.N.H. behaviour has been studied with non-specific nasal provocation tests with methacoline, cold water solution and histamine, so the amount of sneezes were assessed. The results show a reduction of the reaction, previously high, to methacoline and cold water solution tests after 6-12 years of illness in subjects with perennial rhinitis, while the test with histamine always gives higher results. This could mean a reduction of N.S.N.H. during the years of illness, probably connected to the answer of the effector organ, without involvement of that afferent portion of nasal mucosa
Research of non-specific hyperreactivity of upper airways in subjects with gastro-esophageal reflux (G.E.R.): Preliminary reports
Full text linkAn association between asthma and gastro-esophageal reflux (GER) is well recognized but the underlying mechanism is still unclear. The authors suggest that could exist an association between GER and upper airways hyperreactivity and this association could represents the mechanism underlying the lower esophageal sphincter releasing, that determine the reflux. In fact they suppose that, the noxious injury of acid reflux follows a course that could be: pharynx → larynx → bronchi → 1/3 inferior of the esophagus → reflux. From these presuppositions the authors carried out a study on the possible relationship between GER and non-specific hyperreactivity of upper airways on 14 subjects, divided in 2 groups: 10 subjects with functional GER, 4 subjects suffering from GER caused by hiatus hernia as control group. All patients had a thorough medical history, ENT examination with rigid and flexible endoscope, anterior Rhinomanometry (RRM), skin-test for inhalant and alimentary allergens, RAST, audiometric exam, non-specific nasal provocation test (NSNPT) with histamine, using as control the number of sneezes. From a through analysis of objective examination and from the results of the NSNPT with histamine resulted that all subjects with functional GER were rhinopathics. In all tests both in vivo (Skin-test) and in vitro (RAST) for the most common allergens (pollens-inhalant-mycophites-alimentary) the results were negative. The authors also found an involvement of paranasal sinuses that raised: 91% in the patients with recurrents phlogosis due to non specific nasal hyperreactivity; 40.9% in the allergic subjects (20% in the Graminacee +; 32% in the Parietaria O. +; 76% in the Dermatophagoides Pt. +; others 4%); 100% in the ASA-intollerance subjects. The NSNSPT with histamine showed in the group with functional GER a hyperreactivity with sneezes in 6/10 subjects, and 1/4 subjects of the group with GER with hiatus hernia. The RRM variations showed an unilateral nasal hyperreactivity in 6/10, bilateral in 3/10 subjects of the group with functional GER. In the group with GER with hiatus hernia only 1/4 subject showed reliable unilateral RRM variation. From the analysis of data resulted that subjects with functional GER showed a completely involvement of the upper airways and not only of the pharynx and larynx, caused by non specific hyperreactivity at the NSNPT with histamine, associated with a chronic pathology
The non-specific hypersensitivity of the upper and lower airways in Reinke's edema: Preliminary results
No full textReinke's edema is characterized by swelling of the vocal cords, which generally is bilateral but often is more pronounced in one cord. The disease is named after the anatomist Reinke, who undertook a morphological study of the subepithelial connective tissue of the vocal cords in order to investigate edematous spread. In general, swelling of the vocal cords develops gradually and may increase considerably over months or even years. To evaluate an eventual relation ship between airways (nasal and bronchial) and Reinke's edema of the vocal cords, the authors studied 9 subjects suffering from Reinke's edema. These patients underwent to an accurate clinical history, skin-test for inhalant pollens and mycetes to evaluate the eventual presence of specific allergies, non-specific nasal provocation test with Histamine, baseline RRM to evaluate the non-specific nasal hypersensitivity and besides the RRM values has been considered the number of sneezes after Histamine stimulation, finally a bronchial provocation test with ultrasonic fog to evaluate the presence of non-specific hypersensitivity of the lower airways
Kaempferol 3-O-(4’’’-O-acetylrutinoside), a new flavonoid from the fern Dryopteris villarii.
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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