1,720,973 research outputs found
Cross-reactions in patch testing and photopatch testing with ketoprofen, thiaprophenic acid, and cinnamic aldehyde
No full textIn the last 7 years, we have studied 123 patients with allergic reactions to topical arylpropionic anti-inflammatory drugs. We have investigated the rate of sensitization and the irritant potential of one of them, ketoprofen, and its cross-reactivity with such other derivatives as ibuproxam, ibuprofen, naproxen, fenoprofen, flurbiprofen, and thiaprofenic acid. Sensitization was single in most cases, and ketoprofen was the drug most often involved. The combination most frequently found was ketoprofen plus ibuproxam. The most frequent cross-reactions were to fragrance mix, especially cinnamic aldehyde and balsam of Peru, both contact and photocontact sensitizers. Because there is a ketonic group in the molecule of ketoprofen and cinnamic aldehyde and after conversion of thiaprofenic acid, this could be the trigger for this particular allergy and cross-reactivity
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Application of an Early Warning Detection System to batch and semi-batch polymerization processes
No full textThe EWDS is an electronic device designed to recognize, on-line and well in advance, anomalous process conditions in chemical reactors that can lead to runaway reactions.
The EWDS consists of hardware and software parts:
In the hardware part we have:
PT resistance thermometers to measure reactor and jacket temperatures; a data acquisition unit; a supply unit that complies with industrial safety standards and a PC equipped with a special data acquisition card.
The software part is used to save and elaborate data, to show the results on line and to provide warning and alarm signals.
For the bench scale reactor experiments the EWDS performance has been satisfactory. The algorithm, in fact, has detected the runaway events in advance without producing false alarms.
For the industrial experiments two different algorithms have been used.
Algorithm n.1 was able to distinguish between runaway and non-runaway situations, because it is mainly focused on the dynamics inside the reactor.
Algorithm n.2, instead, produced false alarms during the manual opening of the jacket valve by the operator.
The results that I have presented refer to the first versions of the algorithms.
In the future a new version of the EWDS algorithm will be tested. This version uses only the reactor temperature and it does not use derivatives. So the calculation will be simpler compared to the first versions
Immunohistologic evaluation of the effect of cyclosporine treatment on the lichen planus immune infiltrate
No full textWe have investigated immunohistologically the cutaneous immune infiltrate in the lesions of five patients with severe, extensive lichen planus of recent onset before and after 15 days of oral, low-dose cyclosporine therapy (3 mg/kg/day). Before therapy, we observed an abnormal bandlike cellular infiltrate localized in the papillary dermis, composed mostly of CD3+ cells, with a prevalence of CD4+ cells. Infiltrating lymphocytes showed markers of activation (HLA-DR antigens and interleukin 2 receptor), and there were many Langerhans (CD1+) cells in the dermal infiltrate. After 15 days of cyclosporine therapy, we observed a dramatic decrease in the total number of T cells and a corresponding decrease in interleukin 2 receptor-positive activated CD25+ cells and in antigen-presenting cells (CD1+ and CD14b+). These changes were concurrent with clinical improvement. Our results are compatible with the hypothesis that the inhibition of CD4 T cells by cyclosporine might explain the drug's therapeutic action and that the interaction between antigen-presenting cells and CD4 T cells is important in the pathogenesis of lichen planus
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