1,721,247 research outputs found
La catalogazione delle immagini delle notizie bibliografiche e d'archivio in ausilio all'analisi comparata dell'evoluzione della piazza e delle singole emergenze
No full textL’articolo illustra il metodo e i criteri utilizzati per utilizzare in modo comparato e relazionato il cospicuo materiale, in particolare iconografico e cartografico, nell’affrontare lo studio a carattere multidisciplinare come quello avente per oggetto l’evoluzione di Piazza Navona e le sue singole emergenze, da un punto di vista prettamente disciplinare che e’ quello del disegno
APPROACHES TO THE MOLECULAR BASIS OF GENETIC DISEASES
Full text linkThroughout my PhD period, I experimented different approaches to a complex problem, that is, assessing molecular basis of genetic diseases. In the present thesis I will show how both experimental and computational techniques can contribute to the study of typical biochemistry topics, providing non-conventional points of view and advanced technical and technological supports.
The first part of my PhD was focused on physico-chemical investigation, while the second part was devoted to big-data and network analysis. For this reason my thesis is divided into two chapters.
The former describes a typical bottom-up approach. I applied the physical technique of laser light scattering to study the first stages of aggregation of configurational variants of the beta-amyloid peptide, recognized to be either promoting or preventing the Alzheimer Disease, as compared with the wild type peptide. The variants correspond to genetic mutations giving rise to either familial cases of Alzheimer Disease or protection from the pathology. I carried out experiments aimed to assess similarities and differences in the kinetics of evolution of the aggregated species in very dilute solution, mimicking the physiological and pathological conditions. The outcome of this study is the discovery of a correlation between the molecular structure and the physico-chemical behavior, in this case aggregation, constituting the hallmark of the disease.
The results obtained have been published in a peer reviewed journal (Biophysical Chemistry), with the title: “Pathogenic Aβ A2V versus protective Aβ A2T mutation: early stage aggregation and membrane interaction” (2017).
The latter is a top-down approach. I defined the criteria and developed an algorithm for searching big databases with respect to: a) the clinical features of inherited diseases and b) the proteins that are known to be involved in genetically determined diseases. I established searching criteria aiming at regrouping extracted data according to similarity classes in each database. Then, the developed method involves assessing the existence and degree of similarity within and between different clusters. As a result of this approach, we have discovered a correlation between similarity classes extracted from the different databases (the clinical and the biological), thus establishing or suggesting the existence of a biological basis for a genetic disease.
The obtained results have been submitted for publication in a peer reviewed journal with the title: “The Disease Similarity Networks: Correlating the Clinical and Biological Similarity of Inherited Diseases”, while a second manuscript is currently under preparation.
Based on different disciplines, and designed with the typical instruments and methodologies of physics and statistics, both approaches give non-conventional hints for the understanding of the molecular basis of complex genetic diseases
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
A Monte Carlo simulation of liquid 1, 2-dimethoxyethane
No full textMonte Carlo simulations have been carried out for liquid 1,2-dimethoxyethane in the NVT ensemble at 298 K with 125
and 216 molecules. The intermolecular interactions are described as sums of Lennard-Jones and Coulomb terms. The
intramolecular rotations are described by an analytical potential function fitted to MM2 energies. The heat of vaporization
is found in good agreement with the experimental value. While the gas phase is a mixture of gauche and anti conformations,
in the pure liquid the gauche conformation is preferred, as found experimentally. The liquid is disordered with high coordination
numbers and the most evident packing effect is shown by terminal CH3 groups
A mild oxidation of nitrile oxides: a new synthetic route to nitroso carbonyl intermediates
No full textAddition of N-methyl morpholine N-oxide (NMO) to a nitrile oxide solution in dichloromethane at room temperature in the presence of a diene affords nitroso carbonyl adducts in fair yields
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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