1,721,006 research outputs found
THYROID HOMEOSTASIS AND RETINOL CIRCULATING COMPLEX RELATIONSHIPS IN A SEVERE IODINE-DEFICIENT AREA OF SENEGAL
No full textIn adult subjects living in a severely iodine-deficient area (median urinary iodine 10 mu g/L), we evaluated the biochemical parameters of protein malnutrition in relation to thyroid homeostasis. Serum transthyretine (TTR), retinol binding protein (RBP) and retinol, an components of the retinol circulating complex (RCC), as well as ceruloplasmin levels, were determined in 63 subjects (44 F/19 M). These comprised 21 controls, 31 who were euthyroid with goiter WHO stage 2 or 3 and 11 who met the criteria of hypothyroidism (i.e. FT4 4.13 mU/L) with goiter stage no more than fb. No differences in the values of TTR and RBP were found between males and females, whereas the retinol Values were slightly higher in males. The mean retinol binding protein values were lower than the normal range in all three groups but were significantly lower (p<0.01; <0.05) in hypothyroid subjects than in the other two groups. All hypothyroid subjects exhibited reduced retinol binding protein levels and 1/3 of them showed a marked decrease. The circulating levels of transthyretine were also lower than the normal range for western countries. 45% of the hypothyroid, 26% of goitrous and 9% of control subjects exhibited a transthyretine lower than 12 mg/dl, but the mean values were not dissimilar. The mean retinol values were within the normal range in all three groups but were lower in hypothyroid as compared to the controls (<0.01). The resulting retinol/RBP ratio was over 1 in both the whole sample and in the subgroups. Ceruloplasmin levels were in the normal range in all groups. The data indicated that hypothyroid subjects had reduced retinol binding protein and retinol circulating complex network compared to euthyroid subjects
Changing the Mediterranean diet: effects on blood pressure.
No full textAn increase in the polyunsaturated to saturated fatty acid ratio (P:S) in the diet has been reported to reduce blood pressure in man. We have investigated whether an increase in the percentage of saturated fatty acids in the typical Mediterranean diet would affect blood pressure in a sample of healthy rural population of southern Italy. Fifty-seven non-hospitalized normotensive volunteers (29 male, 28 female, aged 30-50 years) were studied. After a 2-week baseline period on their customary diet (P:S = 0.44), they underwent a 6-week isocaloric dietary intervention with a 70\% increase in energy from saturated fatty acids and a corresponding decrease in carbohydrate and mono-unsaturated fat (P:S = 0.23). Thereafter they returned to their usual diet and were followed-up for 6 more weeks (switch-back period). By the end of the intervention period, systolic pressure was increased by 2.6 mmHg in men (P less than 0.05) and by 4.8 mmHg in women (P less than 0.01). Diastolic pressure was not significantly increased, although a significant linear regression of the group average blood pressure over time was observed for both systolic (0.161 mmHg, P less than 0.01) and diastolic pressure (0.107 mmHg, P less than 0.01). After returning to their customary diet, blood pressure returned to baseline (-0.212 mmHg, P less than 0.05 systolic and -0.226 mmHg, P less than 0.01 diastolic). No significant change in body weight occurred throughout the study. These findings suggest that changes in the saturated fatty acid content of the diet with moderate change in the dietary P:S ratio can influence blood pressure to a significant extent
Reduced levels of retinol binding protein characterize hypothyroid children in iodine-deficient area
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Modulazione red-ox dello stress ossidativi da parte dei composti fenolici: meccanismo d'azione e impatto sulla risposta immunitaria cellulo-mediata
No full textDottorato di ricerca in fisiopatologia sperimentale. 12. ciclo. A.a. 1998-99. Supervisore A. Ferro Luzzi Coordinatore V. VanniniConsiglio Nazionale delle Ricerche - Biblioteca Centrale - P.le Aldo Moro, 7, Rome; Biblioteca Nazionale Centrale - Piazza Cavalleggeri, 1, Florence / CNR - Consiglio Nazionale delle RichercheSIGLEITItal
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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