2,722 research outputs found
Characterization of ‘Candidatus Phytoplasma solani’ associated with a maize leaf reddening disease in Turkey
No full textIn recent years, empty or poor grain bearing corn plants with leaf reddening symptoms have been observed in some commercial maize production areas in the Adana province of Turkey. The disease is increasing and causing economic losses. To verify the possible presence of phytoplasmas, leaf samples were tested with P1/Tint and R16F2n/R2 phytoplasma-specific primer pairs after DNA extraction. The 16S ribosomal gene sequence analysis followed by sequence in silico enzyme digestions and phylogenetic analyses allowed the identification of ‘Candidatus Phytoplasma solani’, subgroup of 16SrXII-A related-strain in all symptomatic samples. The positive samples were characterized using tuf and vmp1 genes. In silico restriction fragment length polymorphism and sequence analyses allowed the inclusion of all the positive samples into tuf-type b and V15 molecular types. The sequence analysis indicated the presence of a single genotype in all the tested samples (n = 12). This is the first molecular characterization of a ‘Ca. P. solani’ strain infecting maize plants in Turkey. The identified pathogen is listed in the EPPO A2 list
Creating Realities. Business as a Motif in American Fiction, 1865-1929
No full textSimsek E. Creating Realities. Business as a Motif in American Fiction, 1865-1929. American Culture Studies. Vol 25. Bielefeld: transcript; 2019.Dissertation, Universität Heidelberg, 201
Migraine and Its Treatment from the Medicinal Chemistry Perspective
No full textMigraine is a disease of neurovascular origin that affects the quality of life of more than one billion people and ranks sixth among the most common diseases in the world. Migraine is characterized by a moderate or severe recurrent and throbbing headache, accompanied by nausea, vomiting, and photo-phonophobia. It usually starts in adolescence and is twice as common in women as in men. It is classified as with or without aura and has chronic or acute treatment types according to the frequency of occurrence. In acute treatment, analgesics that relieve pain in the fastest way are preferred, while there are different options in chronic treatment. While non-specific methods were used in the treatment of migraine until the 1950s, triptans, ditans, and CGRP-receptor-dependent therapies (monoclonal antibodies and gepants) started to be used in the clinic more recently. In this Review, we focus on the synthesis, side effects, and pharmacological and pharmacokinetic properties of FDA-approved drugs used in acute and preventive-specific treatment of migraine
A phenylalanine-55 to serine amino-acid substitution in the human glycoprotein IX leucine-rich repeat is associated with Bernard-Soulier syndrome.
No full textThe platelet membrane glycoprotein (GP) Ib-IX-V complex, the major von Willebrand factor receptor on platelets, is absent or dysfunctional in patients with the Bernard-Soulier syndrome (BSS). The four single subunits of the GPIb-IX-V complex (GPIb alpha, Ib beta, IX and V) are molecular products of different genes. Several point mutations and deletions affecting the GPIb alpha gene have been identified as the cause of BSS, whilst in four BSS families a GPIX gene defect has been reported. Moreover, a single case of BSS has been associated with a genetic defect of GPIb beta. We investigated the molecular basis of another case of BSS with a deficient expression of GPIX, as detected by immunofluorescence studies. After amplification of the entire GPIX coding region, nucleotide sequence analysis showed a homozygous single point mutation predicting a phenylalanine to serine substitution at position 55 of the mature GPIX within its unique leucine-rich repeat. By allele-specific oligonucleotide hybridization we confirmed the homozygosity of the patient as well as the carrier state of two out of three of his children studied. Although the parents of the patient, who were first cousins, were no longer alive and thus not available for study, we speculate that the molecular defect observed in the proband was inherited from both parents, who probably were heterozygous for this GPIX gene defect. This study confirms that BSS may be caused by many different subtle molecular defects that often prevent the assembly and expression of a functional GPIb-IX-V complex
A HOMOZYGOUS POINT MUTATION IN A LEUCINE-RICH MOTIF OF PLATELET GLYCOPROTEIN-IX ASSOCIATED WITH BERNARD-SOULIER SYNDROME (BSS)
No full textSome remarks on the geometry of circle maps with a break point
No full textWe study circle homeomorphisms f ∈ C 2 (S 1 {x b }) whose rotation number ρ f is irrational, with a single break point x b at which f ′ has a jump discontinuity. We prove that the behavior of the ratios of the lengths of any two adjacent intervals of the dynamical partition depends on the size of break and on the continued fraction decomposition of ρ f . We also prove a result analogous to Yoccoz’s lemma on the asymptotic behaviour of the lengths of the intervals of trajectories of the renormalization transformation R n (f)
Efeito da cultivar, granulometria e interação destas no conteúdo de arabinoxilanas de farinha integral.
No full textfarinha de trigo integral (FTI), obtida através da moagem do grão inteiro contempla todos os componentes anatômicos do grão nas mesmas proporções como existem na forma intacta, fato que a caracteriza como excelente fonte de ingredientes nutricionais e funcionais (Weaver, 2001). Entre os constituintes do trigo, as arabinoxilanas (AX) vêm atraindo atenção devido sua atividade biológica e efeitos imunológicos benéficos a saúde (Lu et al., 2004 e Wang et al., 2010). As AX são o maior constituinte da fração insolúvel da fibra alimentar presente na fração de farelo de trigo, pertencem ao grupo dos polissacarídeos não amiláceos e são compostas principalmente por xilose e arabinose, ambas pentoses (Mendis & Simsek, 2014)
pXRF study of pottery : State of the art and perspectives
No full textInternational audienceAlthough portable/handheld X-ray Fluorescence instruments are available from decades, the number of publications reporting on-site analyses of pottery remain very limited. Most of them present the paste composition and not the (glazed) décor. After a brief review of the published works about the studies of pottery and glass, we will discuss the advantages (on-site analysis and selection of artefacts, higher number of objects, better statistics …) and drawbacks (light elements and some traces not measured, difficulty to determine the analyzed volume, low quantity of informative elements…). We will take examples on three important series previously analyzed, 18th- century stonewares (from Meissen [1], Delft, China, England, France… belonging mainly to Sèvres collection, France), “Iznik” style tiles covering walls of Edirne mosques (Turkey World Unesco Heritage, Fig. 1 [2]) and Chinese and Vietnamese shards excavated from a medieval harbor (Qalhat, Oman Sultanate [3]) and discuss the two possible ways to extract information: i) the blind eyes approach using PCA and cluster variation statistical analysis, and ii) the comparison of particular element ratios or contents related to the raw materials used for the paste and the glaze (alkalis and earth alkalis, iron and titanium, lead, …) and the coloring and opacifying agents (tin, cobalt, copper, arsenic, nickel, manganese, …). Expected further developments will be discussed. [1] G. Simsek, F. Casadio, Ph. Colomban, K. Faber, L. Bellot-Gurlet, G. Zelleke, V. Milande, E. Moinet, Journal of The American Ceramic Society 97 (2014) 2745-2754.[2] G. Simsek, O. Uunsalan, K. Bayraktar, Ph. Colomban, Ceramics International 45 (2019) 595-605.[3] G. Simsek, Ph. Colomban, S. Wong, B. Zhao, A. Rougeulle, N.Q. Liem, Journal of Cultural Heritage 16 (2015) 159-172
pXRF study of pottery : State of the art and perspectives
No full textInternational audienceAlthough portable/handheld X-ray Fluorescence instruments are available from decades, the number of publications reporting on-site analyses of pottery remain very limited. Most of them present the paste composition and not the (glazed) décor. After a brief review of the published works about the studies of pottery and glass, we will discuss the advantages (on-site analysis and selection of artefacts, higher number of objects, better statistics …) and drawbacks (light elements and some traces not measured, difficulty to determine the analyzed volume, low quantity of informative elements…). We will take examples on three important series previously analyzed, 18th- century stonewares (from Meissen [1], Delft, China, England, France… belonging mainly to Sèvres collection, France), “Iznik” style tiles covering walls of Edirne mosques (Turkey World Unesco Heritage, Fig. 1 [2]) and Chinese and Vietnamese shards excavated from a medieval harbor (Qalhat, Oman Sultanate [3]) and discuss the two possible ways to extract information: i) the blind eyes approach using PCA and cluster variation statistical analysis, and ii) the comparison of particular element ratios or contents related to the raw materials used for the paste and the glaze (alkalis and earth alkalis, iron and titanium, lead, …) and the coloring and opacifying agents (tin, cobalt, copper, arsenic, nickel, manganese, …). Expected further developments will be discussed. [1] G. Simsek, F. Casadio, Ph. Colomban, K. Faber, L. Bellot-Gurlet, G. Zelleke, V. Milande, E. Moinet, Journal of The American Ceramic Society 97 (2014) 2745-2754.[2] G. Simsek, O. Uunsalan, K. Bayraktar, Ph. Colomban, Ceramics International 45 (2019) 595-605.[3] G. Simsek, Ph. Colomban, S. Wong, B. Zhao, A. Rougeulle, N.Q. Liem, Journal of Cultural Heritage 16 (2015) 159-172
Adenomyoepithelioma of the breast presenting as a cancer
No full textAims and background: Adenomyoepithelioma is a rare lesion that can involve the breast tissue. The diagnostic appearance of the lesion can give raise to a difficult differential diagnosis with breast carcinoma. Patients and methods: We report our experience with a case of adenomyoepithelioma whose differential diagnosis with a breast carcinoma was particularly difficult, leading to surgery for definitive histology. Discussion: Few papers are available with evidence about adenomyoepithelioma. The difficult differential diagnosis and the potentiality of malignant evolution of this lesion could in principle justify a conservative surgical approach for final histology
- …
