1,720,962 research outputs found
Approach to synthesis of the natural compound Leopolic Acid A
No full textLeopolic Acid A (1) has recently been isolated from a terrestrial-derived Streptomyces sp isolated from the rhizosphere of the plant Juniperus excels collected from Ukraine.1 It possesses a rare ureido dipeptide Phe-CO-Val attached to 5-dihydro-3-hydroxy-pyrrole-2-one ring.
Ureido-peptides with varying number of amino acids have been previously isolated from actinomycetes ann show intesting biological activities. Noteworthy examples include the microbial alkaline protease inhibitors, (MAPI)-a and b, GE20372 factor A and B, as HIV-1 protease inhibitors, and the pacidamycins, exhibiting anti-Pseudomonas aeruginosa
The unprecedented structural features of Leopolic acid, consisting of an aliphatic side chain attached to the novelpyrrole-2-one residue connected to the ureido dipeptide, prompted us to develop a synthetic strategy of this naturally occurring compound.
The proposed methodology is centred on the condensation of .the 4-substituted 3-hydroxy-1,5-dihydropyrrol-2-one (2) and the ureido dipeptide moiety (3)
Approach to the synthesis of the natural compound Leopolic acid A
No full textLeopolic Acid A (1) has recently been isolated from a terrestrial-derived Streptomyces sp isolated from the rhizosphere of the plant Juniperus excels collected from Ukraine. It possesses a rare ureido dipeptide Phe-CO-Val attached to 5-dihydro-3-hydroxy-pyrrole-2-one ring.
Ureido-peptides with varying number of amino acids have been previously isolated from actinomycetes and show intesting biological activities. Noteworthy examples include the microbial alkaline protease inhibitors, (MAPI)-a and b, GE20372 factor A and B, as HIV-1 protease inhibitors, and the pacidamycins, exhibiting anti-Pseudomonas aeruginosa activity.
The unprecedented structural features of Leopolic acid, consisting of an aliphatic side chain attached to the novel pyrrole-2-one residue connected to the ureido dipeptide, prompted us to develop a synthetic strategy of this naturally occurring compound.
The proposed methodology is centred on the condensation of .the 4-substituted 3-hydroxy-1,5-dihydropyrrol-2-one and the ureido dipeptide moiet
SYNTHETIC STUDIES TOWARDS THE NATURAL PRODUCT LEOPOLIC ACID A
Get PDFThe need to develop new fungicides remains a major driving force as fungal plant pathogens continue to develop resistance against existing fungicides at great speed, and also because new disease situations continually arise.
Natural products have been and still are large reservoirs of new biologically active substances for crop protection development, by serving as lead structures for the discovery of active molecules, often featuring novel and unique modes of action. Many pesticides have been developed from naturally occurring lead compounds. An outstanding example is the class of fungicides that has been generated from strobilurins, antifungal metabolites of myxobacteria.
Aim of the PhD work was the study of new naturally derived antifungal compounds and the development of synthetic sequences which might, in principle, have value in the preparation of the natural products themselves as well as in synthesizing various analogues.
Among a number of possible candidates we have selected a natural products, Leopolic acid A as synthetic target, as it has been reported to be endowed with antifungal activity.
During the PhD period the synthesis of this natural product and structurally related analogues has been carried out. Antifungal and antimicrobial activities of the compounds have been evaluated, and preliminary SAR have emerged
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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