5,290 research outputs found
"Christabel" and the politics of fragmentation
No full textThis thesis attempts to situate Coleridge's “Christabel” as a text that exists at the intersection of 19th century Queer discourse and post-structural theory. By looking at “Christabel” as both a queer text and a fragment poem, this thesis makes the case that one type of discourse informs the other and the fragmentary nature of the poem echoes and supports analysis of “Christabel” as a queer text. It relies on the work of prominent writers on Romantic Fragment Poems as well as Derridean post-structural discourse as a theoretical model to understand Christabel's relationship with Geraldine and the fragmentary nature of the poem that obfuscates their relationship.M.A.Includes bibliographical referencesby Calin Thomas Grajk
Geometric algebra techniques in flux compactifications
No full textWe study constrained generalized Killing (s)pinors, which characterize supersymmetric flux compactifications of supergravity theories. Using geometric algebra techniques, we give conceptually clear and computationally effective methods for translating supersymmetry conditions into differential and algebraic constraints on collections of differential forms. In particular, we give a synthetic description of Fierz identities, which are an important ingredient of such problems. As an application, we show how our approach can be used to efficiently treat N = 1 compactification of M-theory on eight manifolds and prove that we recover results previously obtained in the literature. © 2016 Calin Iuliu Lazaroiu et al.3111Nsciescopu
A Poet at the Fountain: Essays on the Narrative Verse of Guillaume de Machaut
No full textThis collection is the first full-length literary study on Machaut, France’s leading poet and musician of the 14th century. Machaut’s narrative poems, called dits, have only been lightly studied. Here, author William Calin examines the works for their intrinsic merit and for their historical importance in influencing many writers, most notably Chaucer.
William Calin is professor of Romance Languages at the University of Oregon.https://uknowledge.uky.edu/upk_french_and_francophone_literature/1002/thumbnail.jp
Organisational Resilience and Open Innovation of the Celtic Advanced Life Science Innovation Network (CALIN)
No full textThis industry report questions whether open innovation can enhance the organisational resilience of Welsh and Irish life science small and medium-sized enterprises, by sampling the Celtic Advanced Life Science Innovation Network (CALIN) to ask how the two concepts are related and influenced. This provides a significant and original contribution to knowledge and practice, to best understand how the two concepts associate, and how practitioners should allocate their limited resources across three factors (internal, demographic, external) to enhance both concepts together. Report is in both English and Welsh languages
Breast cancer metastasis: a microRNA story
No full textMicroRNAs (miRNAs) are small noncoding RNAs with regulatory functions, which play an important role in breast cancer. Several studies have shown that miRNAs can act either as tumor suppressors or as oncogenes, and that measurement of miRNA expression in malignancies may have diagnostic and prognostic implications. This article highlights a series of three recent studies that prove the involvement of miRNAs in breast cancer metastases. The first proves that miR-10b indirectly activates the pro-metastatic gene RHOC by suppressing HOXD10, thus leading to tumor invasion and metastasis. The second proves that miR-373 and miR-520c can also promote tumor invasion and metastasis, at least in part by regulating the gene CD44. The third identifies miR-335, miR-206, and miR-126 as suppressors of breast cancer metastasis. Loss of miR-335 leads to the activation of SOX4 and TNC (encoding tenascin C), which are responsible for the acquisition of metastatic properties. Altogether, these remarkable findings are important for our understanding of malignant transformation in the breast and may have implications for the management of patients with advanced breast cancer. The use of miRNAs as anticancer therapeutic agents is promising, and such fine molecular studies certainly help in bringing miRNAs closer to clinical practice
Principles of MicroRNA Involvement in Breast Cancer
No full textEditorial on the role of microRNAs in breast cancer
Wujud Dekonstruksi Jacques Derrida dalam Novel Carita Calin Karya Aprilia Fatmawati
No full textThis study aims to examine a form of deconstruction contained in the novel Carita Calin by Aprilia Fatmawati. Bringing marginalized meaning to content to make it look equal. This study consists of two problem formulations taken from just two concepts from Derrida's deconstruction theory, namely binary opposition and new construction of the main character. The purpose of this study is to describe the work of binary opposition and new constructions related to the main character, namely Calin, in the novel Carita Calin by Aprilia Fatmawati. The approach used in this study is the deconstruction approach based on Jacques Derrida's theory. The data source for this research is the novel Carita Calin by Aprilia Fatmawati and the fairy tale Bawang Merah Bawang Putih as the second data source. Data collection technique used is the technique of reading notes. Data analysis techniques using descriptive analysis techniques. The results of this research work are, (1) opposing the binary character Calin in the novel Carita Calin by Aprilia Fatmawati which presents contradictory things that are different from the tales of Bawang Merah Bawang Putih. (2) The new construction in the novel Carita Calin by Aprilia Fatmawati presents a character with a reversal of facts in the story of Bawang Merah Bawang Putih, Calin is not completely evil, Calin and Mora end up getting along as siblings, her mother spoils Mora more than she does, and Calin is the dominant character in the novel story
Involvement of MicroRNAs in Human Cancer: Discovery and Expression Profiling
No full textThe expression of microRNAs (miRNAs) is deregulated in human cancer, with some miRNAs consistently up- or down-regulated in more than one type of neoplasm. The demonstration that aberrantly expressed miRNAs can affect the function of known oncogenes and tumor suppressor genes established molecular links with pathways implicated in malignant transformation. Cell cycle progression, loss of differentiation, increased survival, invasion, and metastasis were shown to be all under the influence of miRNAs, thereby implicating that miRNAs can themselves act as oncogenes or tumor suppressor genes. Besides increasing our knowledge on the molecular basis of cancer, accumulating evidences indicate that miRNA expression profiling has the potential of being translated into clinical applications. Analysis of cancer tissues revealed that miRNAs could be molecular markers useful for cancer classification, prognostic stratification, and drug-response prediction. MiRNAs also emerged as circulating markers, which may become valuable for early diagnosis and follow-up investigations. If we consider that studies on miRNAs in cancer therapy have already produced important results, in just few years, miRNAs have had a great impact in all cancer areas. Whether this will translate into important clinical applications is still too early to say
Introduction to Neuroscience - Neurophysiology
No full textThis is an early draft of a chapter from a new Introduction to Neuroscience textbook, an effort that is:
Open source, available free to students
Faculty created
Peer reviewed (in progress)
High quality, including professional illustrations and learning resources
This textbook is edited by
Elizabeth Kirby, PhD
Melissa J. Glenn, PhD
Noah J. Sandstrom, PhD and
Christina L. Williams, CL
and supported by funding from the National Science Foundation
This early preview of the book is posted by Bob Calin-Jageman, an author Chapter (2 on neurophysiology. The purpose of posting this early-stage chapter here is:
To make it available for Dr. Bob’s Introduction to Neuroscience students
To gather feedback from others interested in this chapter or project
If you have any feedback, find a typo, notice an inaccuracy, etc… please submit your comments to Bob Calin-Jageman via email or social media
Long non-coding RNAs and cancer: a new frontier of translational research?
No full textAuthor manuscriptTiling array and novel sequencing technologies have made available the transcription profile of the entire human genome. However, the extent of transcription and the function of genetic elements that occur outside of protein-coding genes, particularly those involved in disease, are still a matter of debate. In this review, we focus on long non-coding RNAs (lncRNAs) that are involved in cancer. We define lncRNAs and present a cancer-oriented list of lncRNAs, list some tools (for example, public databases) that classify lncRNAs or that scan genome spans of interest to find whether known lncRNAs reside there, and describe some of the functions of lncRNAs and the possible genetic mechanisms that underlie lncRNA expression changes in cancer, as well as current and potential future applications of lncRNA research in the treatment of cancer.RS is supported as a fellow of the TALENTS Programme (7th R&D Framework Programme, Specific Programme: PEOPLE—Marie Curie Actions—COFUND). MIA is supported as a PhD fellow of the FCT (Fundação para a Ciência e Tecnologia), Portugal. GAC is supported as a fellow by The University of Texas MD Anderson Cancer Center Research Trust, as a research scholar by The University of Texas System Regents, and by the Chronic Lymphocytic Leukemia Global Research Foundation. Work in GAC’s laboratory is supported in part by the NIH/ NCI (CA135444); a Department of Defense Breast Cancer Idea Award; Developmental Research Awards from the Breast Cancer, Ovarian Cancer, Brain Cancer, Multiple Myeloma and Leukemia Specialized Programs of Research Excellence (SPORE) grants from the National Institutes of Health; a 2009 Seena Magowitz–Pancreatic Cancer Action Network AACR Pilot Grant; the Laura and John Arnold Foundation and the RGK Foundation
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