133 research outputs found
Prosthetic joint infections
No full textPurpose of reviewProsthetic joint infections (PJIs) represent one of the most disastrous complications in prosthetic surgery, requiring long hospitalization, prolonged antimicrobial treatment and repeated surgical interventions. No gold standard test to formulate diagnosis exist. A combination of high index of suspicion, physical examination, microbiological and biohumoral investigations is required. Therapeutical approach should be based on a multidisciplinary team. In our center, a two-stage approach is preferred. As regards the choice of the empirical antibiotic backbone, individual risk factors for multiple-drug resistant (MDR) pathogens should be considered. Several studies enhance the possibility to shorten the length of antibiotic couses.Recent findingsSome interesting improvements have been made in the setting of PJIs management. As regards diagnosis, novel biomarkers and nuclear imaging are acquiring more importance. Molecular biology techniques also offer the possibility to formulate rapid microbiological identification. The pattern of PJIs is evolving towards higher rates of MDR causes. During the last decade, a number of new antibiotic molecules with activity against MDRs have been approved. Some of them are also available either in oral formulation or as long-acting compounds, offering the opportunity for early patient's discharge, with expected healthcare costs saving.SummaryManagement of PJIs still represents a major threat for clinicians. Improvements in surgical techniques and antibiotic pipeline promise to revolutionize the approach in next years. Despite data from our experience confirm the efficacy of shorter antibiotic courses and the value of new molecules, randomized clinical trials are lacking. More data are needed in order to modify the routine clinical practice
CADEO Update User Manual for the Initialisation Tool
No full textThe departure management system (CADEO) is a tool assisting airport controllers to achieve an optimal departure sequence. The tool not only calculates an optimal sequence concerning the departure traffic but also takes account of the arriving traffic
Innovation by Computer-Aided Design/Computer-Aided Manufacturing Technology: A Look at Infection Prevention in Dental Settings
No full textRecent data indicates limited awareness and compliance on infection prevention procedures by dental offices and by dental laboratories. Guidelines for infection prevention in dentistry have been published by Centres for Disease Control and Prevention since 2003; the section "IX-Special consideration" includes a subsection concerning the prevention in dental laboratories, but it has not been modernised in later versions to fit the needs of traditional and computer-aided technology. Traditional techniques required disinfecting items (impression, chewing waxes, and appliances) with well-suited products, which are also chosen for limiting impression changes or appliance deterioration. Effective procedures are available with difficulties. Some of these contain irritant or non-eco-friendly disinfectants. The transport of impression, to dental laboratories, is often delayed with limited precautions for limiting cross-infection. Gypsum casts are frequently contaminated mainly by bacteria and their antibiotic-resistant strains and even stored for long periods during dental implant supported restoration and orthodontic therapy, becoming a hidden source of infection. Nowadays, computer-aided design/computer-aided manufacturing technology seems to be an interesting way to promote both business and safety, being more comfortable for patients and more accurate than traditional technology. A further advantage is easier infection prevention since, for the most part, mainly digital impression and casts are not a source of cross-infection and the transport of contaminated items is reduced and limited to try-in stages. Nevertheless, a peculiar feature is that a digital electronic file is of course unalterable, but may be ruined by a computer virus. Additionally, the reconditioning of scanner tips is determinant for the optical characteristics and long term use of the scanner, but information for its reconditioning from producers is often limited. This study focuses on some critical points including (a) insufficient guidelines, (b) choice of proper procedure for scanner reconditioning, and (c) data protection in relation to patient privacy
CADEO User Manual for the Runtime Parameters Tool
No full textThe departure management system (CADEO) is a tool assisting airport controllers to achieve an optimal departure sequence. The tool not only calculates an optimal sequence concerning the departure traffic but also takes account of the arriving traffic
Current antibiotic management of prosthetic joint infections in Italy: the 'Udine strategy'.
No full textThe rate of prosthetic joint infections followed and cured at our institution is constantly increasing, in line with epidemiological data from the recent literature. This is probably related to the greater number of knee and hip prostheses implanted every year. For intermediate and late infections, only the two-stage approach is applied, as this demonstrates the best outcome in our experience. Particular attention is paid to microbiological isolation of the pathogen: multiple samples of tissue are collected during the interventions, and kept in culture for a longer period of time than usual. Sonication of prosthetic devices is used to enhance the sensitivity and specificity of the microbiological cultures. Histological examination influences surgical choices either towards implantation of a new prosthesis or replacement of the spacer. An empirical antibiotic backbone of a glycopeptide/lipopeptide and rifampicin is chosen, due to the leading role of Gram-positive bacteria in this setting and the high incidence of methicillin resistance in our centre (>30%), followed by an antibiotic regimen containing linezolid. If specific risk factors are present, an anti-Gram-negative drug is added to the regimen. Duration of therapy depends upon the approach that is chosen, usually being 6 weeks when the prosthesis is removed. Despite at the moment being limited by its small sample size, data from our experience confirms that our empirical approach may represent a valid choice during the early phase of treatment, by keeping linezolid for a step-down therapy of shorter duration (4 weeks). © The Author 2014. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved
Erratum: Small colorectal cystic metastases to the liver: Still a diagnostic dilemma? A report of a case and a review of the literature
No full textSmall colorectal cystic metastases to the liver : still a diagnostic dilemma? A report of a case and a review of the literature
No full textBACKGROUND: Although cystic colorectal metastases are rare (1.8%), they are still a crucial challenge for the surgeon especially in terms of detection and differential diagnosis. Since prognosis after resection is very good (40% 5-year survival), early diagnosis is essential. CASE REPORT: A 55-year-old man was admitted to our hospital with a suspected diagnosis of multiple small liver metastases. He had previously undergone left sided-cholectomy followed by chemotherapy for colonic carcinoma. Computed tomography (CT) revealed multiple small (<15 mm) intrahepatic biliary cysts, suspected for cystic colorectal liver metastases. CONCLUSION: The diagnosis of cystic colorectal liver metastases is quite difficult and it is mostly based on the last-generation magnetic resonance (MR). In spite of this, we must often rely on histological results for a definitive diagnosis
Le Centre d’accueil d’évaluation et d’orientation (CAdEO) : une porte d’entrée territoriale dans les soins en santé mentale
No full textUn premier Centre d’accueil d’évaluation et d’orientation (CAdEO) a été créé à Lyon début juin 2020 dans le but de faciliter l’accès aux soins en santé mentale. Cette structure permet à toute personne qui la sollicite d’accéder à une consultation psychiatrique dans les quelques jours qui suivent. Elle ne met pas en œuvre de suivi, mais elle lui permet d’être rapidement dirigée vers la structure ou le professionnel, d’exercice public ou privé, qui pourra déployer la prise en charge dont elle a besoin.
Pour argumenter ses avis, le CAdEO s’appuie sur une équipe multidisciplinaire, qui comprend des psychiatres, des psychologues et des infirmiers (dont un infirmier en pratique avancée). Son secrétariat est ouvert du lundi au vendredi. Le CAdEO, qui est implanté en centre-ville, travaille en partenariat étroit avec les médecins généralistes de son territoire de santé, ainsi qu’avec tous les dispositifs sanitaires, médico-sociaux et sociaux intervenant dans le domaine de la santé mentale.
Parmi ses consultants, environ 4 personnes sur 5 sont orientées vers le libéral ou l’associatif. Une personne sur 5 est orientée vers les autres dispositifs du secteur de psychiatrie générale dont le CAdEO constitue en ce cas la porte d’entrée
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