1,721,000 research outputs found
[Thyroid nodule: morphostructural diagnosis and molecular substrate]
No full textThis survey offers an up-to-date overview of the latest findings relevant to molecular mechanisms of thyroid carcinogenesis, also based on our considerable experience with regard to the paradigmatic and atypical cytohistogenetic alterations specific to the various forms of thyroid proliferation, both malignant and benign. We have, moreover, illustrated the most recent applicative interchanges of the biomolecular methodologies relating to the diagnostic protocols to be carried out, in order to characterize the tumorous lesions. Particular emphasis has been focused on the role played by the molecular diagnosis of those lesions which cannot be pinpointed using traditional cytologic analysis and which are called "follicular proliferations". Among the innovative, diagnostic methodologies centered on the applications of the latest biomolecular findings relevant to thyroid oncogenesis, the immunocytochemical method, involving galectina-3 staining, plays a pivotal, diagnostic role as a marker of malignancy. In our experience this modern immunohistochemical methodology provides an extremely selective diagnostic support, possessing considerable sensitivity. This molecular approach is able to solve the diagnostic issue raised by the uncertainty of the neutral cytologic diagnostic report which demands a precise biomolecular specification of the nature of the nodules, cytologically set within the framework of the lesions described as aspecific, follicular structure anomalies. Furthermore, the new findings relating to the molecular mechanisms involved in the formation and neoplastic progression of the proliferous thyroid anomalies offer useful elements for the development and application of further genetic-molecular markers for diagnostic and prognostic purposes
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
HIPK2 INDUCE APOPTOSI ATTIVANDO LA REPRESSIONE P53-MEDIATA DELLA GALECTINA-3 E AGISCE COME UN POTENZIALE GENE ONCOSOPPRESSORE
No full textPresentazione Orale. Abstract # C133. Ospedale San Giuseppe, Milan
Antitumor activity of the proteinase inhibitor tetra-p-amidinophenoxyneopentane in a nude mouse model of human melanoma
No full textAn aromatic poly-amidine (tetra-p-amidinophenoxyneopentane, TAPP-Br) exhibiting anti-proteinase activity and known to exert antitumor activity in vitro was analysed for its ability to inhibit the in vivo growth of a human melanoma cell line transplanted in nude mice. 5 x 106 melanoma cells were injected subcutaneously in groups of nude mice and treatment with TAPP-Br was performed (0.125-1 mg/0.2 ml injections, repeated three times at the beginning of the experiment and after 20 days). After 25 days tumors displaying a volume of 0.9-1.8 cm3 were detectable in control untreated mice. Mice treated with TAPP-Br on the other hand did not develop sizable tumors or consistenly developed tumors of significantly smaller sizes. Despite these therapeutic effects, significant chronic toxicity of the compound was observed when administered at higher dosage (500-1000 μg). These side effects, which may hamper the therapeutic use of TAPP-Br, are likely to be circumvented by alternative routes of admi..
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