1,720,983 research outputs found
Autonomic changes during pregnancy: Assessment by spectral heart rate variability analysis
No full textThe aim of this study was to investigate cardiovascular autonomic balance in normal pregnancy through spectral analysis of heart rate variability. For this purpose, electrocardiograms were recorded in 8 nonpregnant women and in 32 pregnant women at 10-39 weeks of gestation. Low- /high-frequency peak (LF/HF) ratio was used as an indirect index of sympathovagal balance. In left lateral recumbency, the LF/HF ratio was lower in pregnant women than in control subjects at all gestational ages. The LF/HF ratio was not affected by turning from left lateral to supine recumbency in control subjects, whereas it significantly increased in pregnant women (eg, from a mean +/- SD of 1.05 +/- 0.81 to 2.18 +/- 1.69 after the 33rd week of gestation). Handgrip at low intensity remarkably increased the LF/HF ratio both in control subjects (from 2.21 +/- 2.76 to 2.73 +/- 1.91) and in pregnant women (from 1.28 +/- 1.17 to 2.24 +/- 0.95 at 34-39 weeks of gestation). The results suggest that a rearrangement of autonomic tone takes place in normal pregnancy, which could be interpreted either as a shift of autonomic balance toward a relative vagal predominance or as the consequence of attenuation of baroreflexes
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
A web-based platform to retrieve user-ranked data from human exome/genome sequencing projects.
No full textGenome and exome sequencing projects produce huge amount of data, which in turns can yield extensive catalogues of human genetic variations. However, how to identify which genetic variations are implicated in the onset and progression of human
diseases remains still a difficult task. New bioinformatic tools are required to efficiently spill out a small number of candidate variants from the large amounts of DNA sequencing data produced. Here we present the development of a platform designed to manage and retrieve data from human exome/genome sequencing projects. The platform integrates heterogeneous information to help the association of variations
to the pathology/phenotype under study. The information can be related to gene features (Gene Ontology, Disease Ontology, OMIM, InterPro annotations), to genomic context, or it can describe the CDS-effects of variants (dbSNP, degree of
deleteriousness) and their confidence in terms of depth of sequence coverage and calling score.
The platform is accessible through a web interface where the user can upload one or more files containing the variants in VCF format. SNPs and microindels are automatically mapped on the genome and stored in a relational database together with
their possible effects on the corresponding transcripts and proteins. A powerful and flexible query system allows then to explore the data applying different criteria which are related to the heterogeneous information stored in the database. The results of the processed query are displayed on a ranked list ordered according to how many of the imposed criteria are satisfied. Therefore the query and the ranking systems allow the user to filter the information at different levels and to directly assess the significance of the results.
The web platform and the query system are based on a scalable and easily configurable XML-based language. This allows to easily face the continuous increase of data volume and heterogeneity and the subsequent database structure updates, without any modification of software code
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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