1,076 research outputs found
Bedouin-Arab women's access to antenatal care at the interface of physical and structural barriers: A pilot study
No full textGottlieb ND, Belmaker I, Bilenko N, Davidovitch N. Bedouin-Arab women's access to antenatal care at the interface of physical and structural barriers: A pilot study. Global Public Health. 2010;6(6):643-656
Novel data according Will Roger`s phenomenon in stomach cancer patients
No full textDubinina V. G., Lukjanchuk О. V., Lurin A. G., Маshukov А. А., Bilenko А. А., Zgura A. N., Raciborsky D. V., Merlich S. V., Shilin I. V. Novel data according Will Roger`s phenomenon in stomach cancer patients. Journal of Education, Health and Sport. 2016;6(6):185-206. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.55178
http://ojs.ukw.edu.pl/index.php/johs/article/view/3570
The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).
755 Journal of Education, Health and Sport eISSN 2391-8306 7
© The Author (s) 2016;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License
(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 05.05.2016. Revised 25.05.2016. Accepted: 25.05.2016.
Novel data according Will Roger`s phenomenon in stomach cancer patients
Dubinina V. G.1, Lukjanchuk О. V.1,2, Lurin A. G.2, Маshukov А. А.1,2, Bilenko А. А.2, Zgura A. N.2, Raciborsky D. V.2, Merlich S. V.2, Shilin I. V.2
Odessa national medical university1
Odessa regional oncologic center2
Acknowledgments: Supported by the Oncological Department of Odessa Regional Pathology Service.
Summary
Mostly Will Roger`s phenomenon means existence of so-called "jumping" or "jumping over the stages" regional metastases in the stomach cancer patients. N1 in the 6th edition means 16 regional lymph nodes involvement, while the N1 seventh edition – only 1-2 of regional lymph nodes involvement. This means that T1N1Mo \ 6th and T1N1Mo \ 7th - not quite the same, and the survival of the two groups will be different. The study, made on the abdominal oncosurgical department of Odessa Regional Oncology Center, included 188 patients operated for gastric cancer in the period 2007-2011. The study included only radically treated patients. Comparison of survival in patients with gastric cancer between 6th revision groups of 7th has been reviewed. The classification mission is to provide differences in the survival rates between the groups.
Regression multivariate Cox analysis showed that 7th UICC classification showed different capability of stratifying survival groups of UICC N classification (P \ 0.01).
Key words: extended lymphatic dissection, TNM classification, Will Roger`s phenomenon, stomach cancer
URI Disambiguation in the Context of Linked Data
No full textThe Linked Data initiative has given rise to an increasing number of RDF datasets, many of which are freely accessible online. These resources often arise as a result of database exports; however sufficient consideration may not be given to the unseen implications caused when they are used in the wider context of the Semantic Web. This paper investigates two popular resources, DBLP and DBpedia, and discusses whether the issues regarding identity management and co-reference resolution have been suitably addressed. We find that a large percentage of authors in DBLP have been conflated, and that disambiguation pages have been incorrectly linked using owl:sameAs within DBpedia. Systems for dealing with these issues are presented, and directions are given for future research
Molecular genetic characteristics of gastric cancers from the surgeon’s point of view
No full textDubinina V. G., Mashukov A. A., Lukyanchuk O. V., Bilenko A. A., Zgura A. N., Raciborsky D. V., Lee S. N. Molecular genetic characteristics of gastric cancers from the surgeon’s point of view. Journal of Education, Health and Sport. 2016;6(11):592-621. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.200394
http://ojs.ukw.edu.pl/index.php/johs/article/view/4063
The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).
755 Journal of Education, Health and Sport eISSN 2391-8306 7
© The Author (s) 2016;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License
(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 02.11.2016. Revised 22.11.2016. Accepted: 30.11.2016.
MOLECULAR GENETIC CHARACTERISTICS OF GASTRIC CANCERS FROM THE SURGEON’S POINT OF VIEW
V. G. Dubinina1, A. A. Mashukov2, O. V. Lukyanchuk2, A. A. Bilenko1, A. N. Zgura2,
D. V. Raciborsky2, S. N. Lee2
1Odessa National Medical university
2Odessa Regional Oncology center
Summary
A study on the expression of oncoproteins in stomach` carcinomas, has been turned into a real research basically due to the abundance of results and their comprehensive interpretations. The study carried out on the abdominal onco-surgical department of Odessa Regional Oncology Center, included a study of 188 patients operated on for gastric cancer (GC) between 2007-2011. In all cases was performed the so-called lymphadenectomy for the principal reason of extensive preventive biopsy of visually unchanged lymph nodes. We spend a multivariate analysis of interactions between the expression of oncoproteins p53, VEGFR-3, erbB2, Ki67 and micro involvement of tumor vasculature (ly, v), the local growth (T), the presence of residual tumor tissue (the R), the degree of tumor differentiation (the G) the degree of regional lymph nodes involvement (N) and type of infiltration (Inf α, β, Inf Υ).
Keywords: Stomach cancer, Immunohistochemistry and Oncoproteins
КЛІТИННІ ФЕНОТИПИ ЗЛОЯКІСНИХ ПУХЛИН ШЛУНКА ЕПІТЕЛІАЛЬНОГО ПОХОДЖЕННЯ = CELLULAR PHENOTYPES OF MALIGNANT TUMORS OF THE STOMACH OF EPITELIAL ORIGIN
No full textMashukov A. O., Lurin A. G., Tkachenko O. I., Zgura O. M., Bilenko O. A., Ratsiborsky D. V., Merlich S.V., Shilin I.V., Maksimovsky V. E., Boychenko A. I., Sirbu V. M. CELLULAR PHENOTYPES OF MALIGNANT TUMORS OF THE STOMACH OF EPITELIAL ORIGIN. ВІСНИК МОРСЬКОЇ МЕДИЦИНИ. 2020;3(88):45-50. ISSN 0049-6804.
DOI http://dx.doi.org/10.5281/zenodo.4118651
http://www.herald.com.ua
УДК 616.33-006.6-089-076/-078
DOI http://dx.doi.org/10.5281/zenodo.4118651
КЛІТИННІ ФЕНОТИПИ ЗЛОЯКІСНИХ ПУХЛИН ШЛУНКА ЕПІТЕЛІАЛЬНОГО ПОХОДЖЕННЯ
А. О. Машуков1,2, А. Г. Лурін2, О. І. Ткаченко1, О. М. Згура2, О. А. Біленко1,
Д. В. Раціборський2, С. В. Мерліч2, І. В. Шілін2, В. Є. Максимовський1, А. І. Бойченко2,
В. М. Сирбу2
Одеський національний медичний університет1, Україна;
КНП «Одеський обласний онкологічний диспансер»2, Україна
CELLULAR PHENOTYPES OF MALIGNANT TUMORS OF THE STOMACH OF EPITELIAL ORIGIN
Mashukov A. O.1,2, Lurin A. G.2, Tkachenko O. I.1, Zgura O. M.2, Bilenko O. A.1, Ratsiborsky D. V.2, Merlich S. V.2 , Shilin I. V.2, Maksimovsky V. E.1, Boychenko A. I.2, Sirbu V. M.2
Odessa National Medical University1, Ukraine;
KNP "Odessa Regional Center for Oncology"2, Ukraine
[email protected]
Summary
The aim: to study the effect of cell phenotype of gastric tumors on the survival of patients treated according to standard protocols. Object and methods of research. The work presents the results of a clinical study conducted on the basis of two medical institutions - the National Cancer Institute and the abdominal oncology surgery department of the Odessa Regional Oncology Center. 221 patients underwent surgery for gastric cancer (MS) from 2007 to 2013. The mean age of patients was 60.88 ± 10.5 years, men - 180, women - 41. All patients underwent surgery, performed 143 gastrectomies and 78 distal subtotal resections of the stomach. Results. All patients included in the study were radically operated. Tumors removed during surgery were examined using histological, cytological, immunohistochemical methods and genetic tests. The obtained research results are monitored for the presence / absence of clinical parallels and mathematical correlations between them. It is concluded that some combinations of immunohistochemical (IHC) markers are effective in separating groups of patients with different biology of gastric cancer. Survival of groups of patients was analyzed on the basis of analysis of molecular markers VEGFR, p53, Her2, Ki-67 and standard histological parameters (stage, degree of differentiation, etc.). The results obtained taking into account the survival and life expectancy in this category of patients allowed us to assess the feasibility and effectiveness of our proposed classification. Conclusions. More advanced surgeries, including D2 lymph dissection, were more effective in microsatellite-unstable and Epstein-Barr virus-associated gastric cancer.
Key words: gastric cancer, oncoproteins, immunohistochemical study, new classification
Mikhail Bilenko
No full textIn certain clustering tasks it is possible to obtain limited supervision in the form of pairwise constraints, i.e., pairs of instances labeled as belonging to same or different clusters. The resulting problem is known as semi-supervised clustering, an instance of semi-supervised learning stemming from a traditional unsupervised learning setting. Several algorithms exist for enhancing clustering quality by using supervision in the form of constraints. These algorithms typically utilize the pairwise constraints to either modify the clustering objective function or to learn the clustering distortion measure. This chapter describes an approach that employs Hidden Markov Random Fields (HMRFs) as a probabilistic generative model for semi-supervised clustering, thereby providing a principled framework for incorporating constraint-based supervision into prototype-based clustering. The HMRF-based model allows the use of a broad range of clustering distortion measures, including Bregman divergences (e.g., squared Euclidean distance, KL divergence) and directional distance measures (e.g., cosine distance), making it applicable to a number of domains. The model leads to the HMRF-KMeans algorithm which minimizes an objective function derive
Some novel ways of gastric cancer patients treatment personification
No full textKirkilevsky S. I., Lurín A. G., Dubinina V. G., Lukyanchuk O. V., Mashukov A. A., Bilenko A. A., Zgura A. N., Osadchy D. N., Maksimovskiy V. E. Some novel ways of gastric cancer patients treatment personification. Journal of Education, Health and Sport. 2017;7(5):516-538. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.801825
http://ojs.ukw.edu.pl/index.php/johs/article/view/4499
The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017).
1223 Journal of Education, Health and Sport eISSN 2391-8306 7
© The Author (s) 2017;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License
(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 05.05.2017. Revised: 23.05.2017. Accepted: 31.05.2017.
UDK 616.33-006.6-089-085.277.3
SOME NOVEL WAYS OF GASTRIC CANCER PATIENTS TREATMENT PERSONIFICATION
S. I. Kirkilevsky1, A. G. Lurín3, V. G. Dubinina2, O. V. Lukyanchuk2,3,
A. A. Mashukov1,2,3, A. A. Bilenko2, A. N. Zgura3, D. N. Osadchy2, V. E. Maksimovskiy2
National Cancer Institute1, Kiev
Odessa National Medical university2, Odessa
Odessa Regional Oncology Center3, Odessa
Abstract
In this paper the authors perform the analysis of molecular and morphological factors influencing the survival of patients with gastric cancer (n = 221). They analyzed the survival rate in this group of patients based on the analysis of molecular markers VEGFR, p53, Her2, Ki-67. Measured role in the survival such factors as the degree of differentiation of primary gastric tumors, the presence of microscopic tumor involvement of perineural and perivascular spaces, the degree of invasion to gastric wall by T1 = 1 and to T4a = 4, T4b = 5, number of regional lymph nodes affected by metastasis, and other factors. As an arbitrator used survival curves calculated by the method of R. J. Cox, time of lifespan, measured in months, as well as a comparison of the areas under the curves of survival.
Keywords: gastric cancer (GC), lymph node dissection, multiorgan resection, immunohistochemistry, genetic classification
Evaluation advanced lymph node dissection impact on long-term survival rate of gastric cancer patients
No full textDubinina V. G., Mashukov A. A., Zgura A. N., Bilenko A. A., Merlich S. V., Raziborsky D. V., Shilin I. V. Evaluation advanced lymph node dissection impact on long-term survival rate of gastric cancer patients. Journal of Education, Health and Sport. 2015;5(4):52-71. ISSN 2391-8306. DOI: 10.5281/zenodo.16594
http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%284%29%3A52-71
https://pbn.nauka.gov.pl/works/553136
http://dx.doi.org/10.5281/zenodo.16594
Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011 – 2014 http://journal.rsw.edu.pl/index.php/JHS/issue/archive
Deklaracja.
Specyfika i zawartość merytoryczna czasopisma nie ulega zmianie.
Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r.
The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014).
© The Author (s) 2015;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License
(http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 20.01.2014. Revised 27.02.2015. Accepted: 15.03.2015.
Evaluation advanced lymph node dissection impact on long-term survival rate of gastric cancer patients
V. G. Dubinina1, A. A. Mashukov1, A. N. Zgura2, A. A. Bilenko1, S. V.Merlich2, D. V. Raziborsky2, I. V.Shilin2
Odessa National Medical University1, Odessa, Ukraine
Odessa Regional Oncological Dispansery2, Odessa, Ukraine
Abstract
Over a period of 2007-2011 188 stomach cancer (SC) patients have been included in the research in abdominal oncosurgical department of Odessa regional oncological dispensary. It was retrospective, one-center, nonrandomized research. Volume of lymph node dissections differed by quantity of lymph nodes to be removed. All patients were divided into three groups. Patients with D1 or D1+ lymph node dissections have been performed, totally 90 patients are included in group of historical control. The main group includes 33 patients to whom D3 lymph node dissections is executed and, finally, control group – 65 patients dissected up to the D2 volume. In all cases so-called lymph node dissections for principal reasons have been executed. The multifactorial analysis of patients survival is implemented depending on a type of a lymph node dissections, a stage of the cancer, number of involved lymph nodes, involvement of the tumoral microcirculatory net (ly is carried out, v) signs of a perinevral invasion (Nev), availability of residual tumoral tissue (R), degree of a differentiation (G). Regardless of a disease stage, SC at 60% of patients, represented with initially hematologicaly disseminated disease. 40% of SC`s had no signs of intratumoral microcirculatory net involvement even in case of more than 15 regional lymph nodes are involved. In the absence of a SC perinevral invasion appeared to be the most precise predictive marker. The conclusion is made some brand new additional prognostic factors could play a crucial role in more accurate patients selection for expanded lymph node dissections.
Keywords: stomach cancer, extended lymph node dissections
Combined Optical And Electrical Analysis of AlGaN-Based Deep-UV LEDs Reliability
No full textThis paper describes an analysis of the reliability of AlGaN-based
deep-UV Light-Emitting Diodes (LEDs) emitting in the range 280-
340 nm. LEDs have been aged at their nominal operating current,
and during treatment their electrical and optical characteristics have
been continuously monitored.
Measurement results show that (i) constant current stress can
induce degradation of the optical power emitted by the devices; (ii)
degradation is more prominent at low measuring current level, thus
suggesting that efficiency decrease is related to the generation of
non-radiative paths; (iii) degradation does not imply a significant
variation of the operating voltage of the devices, thus indicating that
the characteristics of the ohmic contacts are stable over stress time;
(iv) optical power decrease takes place together with modifications of
the C-V apparent charge profiles, indicating that the generation of
non-radiative paths is related to charge instabilities in the QW region
Coronal holes and the solar polar field reversal
No full textThe relationship between the solar polar magnetic field
reversal and coronal hole evolution is investigated for the time
interval from 1996 to 2001.
The distribution of coronal holes shows some evolutionary changes in
relation to the polarity reversals, and these changes appear to
be coordinated with changes in the global magnetic field structure,
suggesting that the polar reversal originates from global processes.
There are periods when the character of the
coronal hole distribution on the solar disk changes significantly,
indicating that the magnetic field structure changes.
These can be interpreted as periods of
rearrangement of the multipole magnetic field structure.
It is found that the evolution of the geometric structure of the photospheric
magnetic field during these periods is not characterized by a continuous
transition from one dominant structure to another, but by relatively sudden
rearrangement of the dominant geometrical structure of the magnetic field.
These coronal holes and photospheric magnetic field
rearrangements coincide with the polar photospheric magnetic field
strength variations.
The minimum phase of the solar cycle is dominated by the
dipole component of the global solar magnetic field. The zonal magnetic field
structure and zonal non-polar coronal hole distribution existed at that
time.
The sectorial magnetic field structure appears when the polar field strength
reaches 0.7 of its maximum value in the corresponding hemisphere.
This structure was established at different times in each hemisphere.
In the north hemisphere it has existed since November 1998 and in the south hemisphere
it has existed since October 1997. The rearrangement from one configuration to
another occurs during a short time period, about solar rotations.
The coronal hole number and area evolution indicates a
redistribution of positive-polarity and negative-polarity photospheric
magnetic fields inside these longitudinal sectors, which reflects the solar polar
field reversal
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