3,121 research outputs found
DIGITAL TWIN A SCALA URBANA : Indagine critica su concettualizzazione, componenti, approcci di sviluppo e tecnologie abilitanti
No full textIl volume prende le mosse da un’analisi delle sfide e delle opportunità
aperte dalla cosiddetta transizione digitale nella gestione dell’ambiente
costruito in termini di produttività, efficienza e sostenibilità, esaminando le
potenzialità introdotte dal paradigma del Digital Twin (DT).
Il contributo specifico della ricerca che sottende il volume ha l’obiettivo di fornire un quadro aggiornato di concettualizzazione e sviluppo del Digital
Twin alla sala urbana (chiamato City Digital Twin – CDT), intesa come riferita
alla dimensione che va dal quartiere all’intera città. La ricerca sul CDT ne
indaga lo stato dell’arte, l’attuale livello tecnico, i progressi recenti nella ricerca e nella sperimentazione, mettendone in luce criticità, prospettive e tendenze future; il tutto considerandone il ruolo fondamentale come strumento di supporto alle decisioni per la pianificazione, la gestione e la
governance delle città, in particolare di quelle che affrontano le sfide imposte dalla transizione energetica e clima neutrale.
Inoltre, il volume propone una serie di metriche descrittive ed una tassonomia di classificazione dei CDT, fornisce informazioni sistematizzate sui potenziali ambiti di applicazione, riferimenti ai principali attori e stakeholders coinvolti nello sviluppo e gestione, individua le possibili architetture concettuali e le tecnologie abilitanti, utili alle municipalità
che intendano intraprendere il percorso di creazione di un CDT.
La ricerca è il risultato del lavoro svolto dall’autrice Rossella Roversi nell’ambito del Master Universitario di II livello in “Construction Digital Twin e Artificial Intelligence. Tecnologie e processi digitali nell’ambiente costruito” erogato dalla Sapienza Università di Roma e coordinato dalla seconda autrice, Sofia Agostinelli
Zigaina. Paesaggio come anatomia
No full textIl volume costituisce catalogo del progetto espositivo articolato in tre sedi e rivolto all'opera calcografica di Giuseppe Zigaina. L'opera si apre con il saggio in forma epistolare di Claudio Magris indirizzato a Zigaina. Prosegue con il testo di Francesca Agostinelli che si rivolge alla produzione calcografica dell'artista dal punto di vista storico-artistico. "Paesaggio come anatomia", il racconto di Giuseppe Zigaina da cui prende titolo il progetto, chiude la sezione dei saggi. L'inedito servizio fotografico che Danilo De Marco dedica a Zigaina correda e impreziosisce il volume.La sezione degli apparati fornisce una puntuale biografia e una bibliografia regionata sull'opera grafica dell'autor
Robust estimators of the generalized loggamma distribution
No full textWe propose robust estimators of the generalized log-gamma distribution and, more generally, of location-shape-scale families of distributions. A (weighted) Qτ estimator minimizes a τ scale of the differences between empirical and theoretical quantiles. It is n1/2 consistent; unfortunately, it is not asymptotically normal and, therefore, inconvenient for inference. However, it is a convenient starting point for a one-step weighted likelihood estimator, where the weights are based on a disparity measure between the model density and a kernel density estimate. The one-step weighted likelihood estimator is asymptotically normal and fully efficient under the model. It is also highly robust under outlier contamination. Supplementary materials are available online.Fil: Agostinelli, Claudio. Universita' Ca' Foscari Di Venezia; ItaliaFil: Marazzi, Alfio Natale. Universite de Lausanne; SuizaFil: Yohai, Victor Jaime. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Matemática; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
Case-Wise and~Cell-Wise Outliers Detection Based on~Statistical Depth Filters
No full textAccording to the classical case-wise contamination model, observations are considered as the units to be identified as outliers. Alqallaf et al. (2009) showed the limits of this approach, especially for a larger number of variables, and introduced the Independent contamination model, or cell-wise contamination, where the cells are the units to be identified as outliers. For the estimation problem, one approach to deal, at the same time, with both type of contamination is filter out the contaminated cells from the data set and then apply a robust procedure able to handle case-wise outliers and missing values. In this work we deal with the outliers detection task, taking into account both types of contamination. We propose to use the depth filters introduced by Agostinelli (2021) as detection procedure which is able to identify both case-wise and cell-wise outliers. We investigated the finite sample performance by a small simulation study, comparing the depth filters with the detection rules available in literature
Nutations in growing plant shoots as a morphoelastic flutter instability
No full textGrowing plant shoots exhibit spontaneous oscillations that Darwin observed, and termed ‘circumnutations’. Recently, they have received renewed attention for the design and optimal actuation of bioinspired robotic devices. We discuss a possible interpretation of these spontaneous oscillations as a Hopf-type bifurcation in a growing morphoelastic rod. Using a three-dimensional model and numerical simulations, we analyse the salient features of this flutter-like phenomenon (e.g. the characteristic period of the oscillations) and their dependence on the model details (in particular, the impact of choosing different growth models) finding that, overall, these features are robust with respect to changes in the details of the growth model adopted
Robust multivariate estimation based on statistical depth filters
No full textIn the classical contamination models, such as the gross-error (Huber and Tukey contamination model or case-wise contamination), observations are considered as the units to be identified as outliers or not. This model is very useful when the number of considered variables is moderately small. Alqallaf et al. (Ann Stat 37(1):311–331, 2009) show the limits of this approach for a larger number of variables and introduced the independent contamination model (cell-wise contamination) where now the cells are the units to be identified as outliers or not. One approach to deal, at the same time, with both type of contamination is filter out the contaminated cells from the data set and then apply a robust procedure able to handle case-wise outliers and missing values. Here, we develop a general framework to build filters in any dimension based on statistical data depth functions. We show that previous approaches, e.g., Agostinelli et al. (TEST 24(3):441–461, 2015b) and Leung et al. (Comput Stat Data Anal 111:59–76, 2017), are special cases. We illustrate our method by using the half-space depth
An EPR study on the conformation of the copper sites of Japanese lacquer-tree laccase
No full textAt liquid nitrogen temperature, the electron paramagnetic resonance (EPR) spectrum of type 1 Cu, in the type 2 Cu depleted Japanese laccase, was modified in a similar way by addition of urea, azide, or by acidification to pH ≤ 4.5. The same effect on the type 1 Cu spectrum was produced in the native enzyme by urea or azide. The EPR parameters in the g region became similar to those measured at room temperature, which are different from those measured at liquid nitrogen [L. Morpurgo, E. Agostinelli, M. Senepa, and A. Desideri, J. Inorg. Biochem. 24, 1 (1985)]. It is believed that urea, azide, and low pH prevent the formation, at low temperature, of an additional hydrogen bond between protein residues, responsible for a local conformational change involving the type 1 Cu. The type 2 Cu EPR spectrum was not significantly affected by urea and pH. © 1986
A fully parametric approach to minimum power-divergenceestimation
No full textC. Agostinelli, A. Cerioli, D. Perrotta, M. Rian
Novel polyamine analogues: from substrates towards potential inhibitors of monoamine oxidases.
No full textPolyamine analogues are extensively researched investigated for their potential pharmacological applications as anticancer (Casero et al. 2009) and antimalarial agents (Verlinden et al., 2011), as well as in the development of multitarget-directed ligands (MTDLs) for novel therapies in neurodegenerative and other multi-factorial diseases (Melchiorre et al. 2010). In the MTLDs field, the polyamine backbone behaves as a “universal template”, able to bind different biological targets with an affinity and selectivity that may be fine-tuned by inserting appropriate substituents on nitrogen atoms and by varying the polymethylene chain lengths (Minarini et al. 2010). In the search of new MTDLs to combat neurodegenerative diseases, we designed new polyamines with the aim to inhibit additional target involved in these pathologies. Among these, human monoamine oxidases (MAOs) are emerging potential targets (Bortolato et al., 2008, Boomsma et al., 2003), since may contribute to the oxidative damage involved not only in neurodegenerative diseases but also in other ones and other pathologies, such as diabetes, cardiovascular and inflammatory disorders (Cohen and Tong 2010). Monoamine oxidases (MAO A and MAO B) and Semicarbazide-Sensitive Amine Oxidase/Vascular Adhesion Protein-1 (SSAO/VAP-1) catalyze the oxidative deamination of biogenic amines to produce aldehyde, hydrogen peroxide and ammonia. The starting points of our study were the negligible enzyme activities of MAOs and SSAO/VAP-1 on spermine and our previous results on Bis-BZA-DIADO, which we found able to inhibit both MAO B and SSAO/VAP-1 (Bonaiuto et al., 2012). Eight novel synthetic polyamines were tested as substrates and inhibitors on SSAO/VAP-1 and MAOs. From the kinetic studies carried out so far, we found novel substrates of SSAO/VAP-1 and two novel types of specific MAOs inhibitors: BD28, more selective for MAO B (Ki= 32 M) and NT27 (Ki = 15 M). Interestingly, NT 27 acts as an irreversible inhibitor of MAO A while, on MAO B, it behaves as a mixed and reversible inhibitor. Further studies are in progress to understand elucidate the binding mode of these compounds to MAOs, in such a way, to modify their structure in order to improve their affinity and selectivity for future application as MTLDs in neurodegenerative diseases
Un amour de Proust, Alfred Agostinelli (1888-1914)
No full textInternational audienceThis first biography of Alfred Agostinelli, Proust's chauffeur, presented by Proust as his secretary, sheds light on the primordial role he played in the life of the author of La Recherche and the genesis of his work.Alfred Agostinelli was this handsome young man, with a sulphurous reputation, whom Proust met in Cabourg in 1907, and of whom he said that, along with his father and mother, he was one of the people he had loved the most. On the front page of the Figaro, he evoked her "young beardless face", compared her to Saint Cecilia, to "a nun of speed" and prophesied her death in an accident. He sheltered him with his girlfriend in his home, noted his actions in his notebooks, and pursued him to Monaco to obtain his return after their separation.Unpublished documents from public and private archives, testimonies, drafts of the writer have allowed Jean-Marc Quaranta to go beyond the clichés and to draw for the first time a precise portrait of Agostinelli, to deliver the account of his life and especially to restore the true relationship, of a rare intensity, that he maintained with Marcel Proust until their rupture and his tragic disappearance in May 1914.Unexpected and well-founded information on the writer's biography decisively renews the knowledge we had about the years 1913-1914, which were essential in the development of his work. Thanks to these new elements, it is possible to better identify and understand the beginnings of La Prisonnière and Albertine disparue, of which Agostinelli was the main inspiration.Cette première biographie d’Alfred Agostinelli, le chauffeur de Proust présenté par ce dernier comme son secrétaire, éclaire le rôle primordial qu’il eut dans l’existence de l’auteur de la Recherche et la genèse de son oeuvre.Alfred Agostinelli fut ce beau jeune homme, à la réputation sulfureuse, rencontré à Cabourg en 1907, dont Proust disait qu’il était avec son père et sa mère l’une des personnes qu’il avait le plus aimée. En première page du Figaro, il évoque son « jeune visage imberbe », le compare à sainte Cécile, à « une nonne de la vitesse » et prophétise sa mort dans un accident. Il l’abrite sous son toit avec sa compagne, note ses faits et gestes dans ses carnets, le poursuit jusqu’à Monaco pour obtenir son retour après leur séparation.Documents inédits issus d’archives publiques et privées, témoignages, brouillons de l’écrivain ont permis à Jean-Marc Quaranta de dépasser les clichés et de dresser pour lapremière fois un portrait précis d’Agostinelli, de livrer le récit de sa vie et surtout de restituer la véritable relation, d’une rare intensité, qu’il entretint avec Marcel Proust jusqu’à leur rupture et à sa disparition tragique en mai 1914.Des informations inattendues et solidement étayées sur la biographie de l’écrivain renouvellent de manière décisive les connaissances que l’on pouvait avoir sur les années 1913-1914, essentielles dans l’élaboration de son oeuvre. Grâce à ces éléments nouveaux, il est possible de mieux cerner et comprendre les prémices de La Prisonnière et d’Albertine disparue dont Agostinelli fut le principal inspirateur
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