2,796 research outputs found
La enseñanza de la matemática en la formación docente para la escuela primaria
No full textLa enseñanza de la matemática en la formación docente primaria constituye un trabajo de tipo exploratorio realizado durante los últimos meses del año 2008 y el año 2009, a cargo de un equipo de trabajo coordinado por Patricia Sadovsky. Esta producción focaliza en cuestiones relevantes sobre el problema de la enseñanza de la matemática y los debates que se suscitan en ese campo especialmente en el nivel de la formación docente, considerando su complejidad
MS
No full textthesisThe purpose of this study was to compare the Cardiff and Sadovsky methods of daily fetal movement counts for maternal compliance, perception of difficulty, and reactions. Maternal-fetal attachment was also evaluated in relationship to compliance. The pretest-posttest control group design was chosen for this study. Eighty women between 35 and 39 weeks gestation were randomly assigned to one of the two methods to count fetal movement. Fifty-six women completed the counts for 1 week. There were no statistically significant differences in compliance, perceived difficulty or reactions between the groups of women who used the Cardiff and Sadovsky methods. Maternal-fetal attachment was not correlated with completion of the movement counts. Some of the women did feel that counting fetal movements made them feel anxious about their baby. Implications from this study include maternal compliance and reaction issues. Further research is needed on fetal movement counts to evaluate their use as an antenatal screening tool
Intercambios, influencias y tensiones en la relación entre una tesista y su directora : relato de una experiencia
No full textFil: Sadovsky, Patricia. Universidad de San Andrés. Escuela de Educación; Argentina.Fil: Duarte, Betina. Universidad de San Andrés. Escuela de Educación; Argentina.La Serie “Documento de Trabajo” difunde conferencias dictadas en el ámbito del Seminario Permanente de Investigación de la Especialización y la Maestría en Educación y del Doctorado en Educación. El Seminario Permanente de Investigación tiene el propósito de estimular la producción y difusión de la investigación en el campo de la Educación. Tiene, además, el objetivo de familiarizar a los estudiantes de posgrado con la producción de conocimiento riguroso en el área. Entre los expositores se cuentan fundamentalmente investigadores formados y, eventualmente, expertos en planificación y política de la educación. También, se encuentran egresados del Doctorado de la Escuela con sus trabajos de tesis terminados
The Expression and Localization of N-Myc Downstream-Regulated Gene 1 in Human Trophoblasts
No full textThe protein N-Myc downstream-regulated gene 1 (NDRG1) is implicated in the regulation of cell proliferation, differentiation, and cellular stress response. NDRG1 is expressed in primary human trophoblasts, where it promotes cell viability and resistance to hypoxic injury. The mechanism of action of NDRG1 remains unknown. To gain further insight into the intracellular action of NDRG1, we analyzed the expression pattern and cellular localization of endogenous NDRG1 and transfected Myc-tagged NDRG1 in human trophoblasts exposed to diverse injuries. In standard conditions, NDRG1 was diffusely expressed in the cytoplasm at a low level. Hypoxia or the hypoxia mimetic cobalt chloride, but not serum deprivation, ultraviolet (UV) light, or ionizing radiation, induced the expression of NDRG1 in human trophoblasts and the redistribution of NDRG1 into the nucleus and cytoplasmic membranes associated with the endoplasmic reticulum (ER) and microtubules. Mutation of the phosphopantetheine attachment site (PPAS) within NDRG1 abrogated this pattern of redistribution. Our results shed new light on the impact of cell injury on NDRG1 expression patterns, and suggest that the PPAS domain plays a key role in NDRG1's subcellular distribution. © 2013 Shi et al
Intriguing symmetry in statistical structures of Siberian larch transcriptome
No full textThe paper presents a novel approach to infer a structuredness in a set of symbol sequences such as transcriptome nucleotide sequences. A distribution pattern of triplet frequencies in the Siberian larch (\textit{Larix sibirica}~Ledeb.) transcriptome sequences was investigated in the presented study. It was found that the larch transcriptome demonstrates a number of unexpected symmetries in the statistical and combinatorial properties
Performing Regular Operations with 1-Limited Automata
No full textThe descriptional complexity of basic operations on regular languages using 1-limited automata, a restricted version of one-tape Turing machines, is investigated. When simulating operations on deterministic finite automata with deterministic 1-limited automata, the sizes of the resulting devices are polynomial in the sizes of the simulated machines. The situation is different when the operations are applied on deterministic 1-limited automata: while for boolean operations the simulations remain polynomial, for product, star, and reversal they cost exponential in size. These bounds are tight
Proline-rich tyrosine kinase 2 mediates gonadotropin-releasing hormone signaling to a specific extracellularly regulated kinase-sensitive transcriptional locus in the luteinizing hormone beta-subunit gene
No full textG protein-coupled receptor regulation of gene transcription primarily occurs through the phosphorylation of transcription factors by MAPKs. This requires transduction of an activating signal via scaffold proteins that can ultimately determine the outcome by binding signaling kinases and adapter proteins with effects on the target transcription factor and locus of activation. By investigating these mechanisms, we have elucidated how pituitary gonadotrope cells decode an input GnRH signal into coherent transcriptional output from the LH beta-subunit gene promoter. We show that GnRH activates c-Src and multiple members of the MAPK family, c-Jun NH2-terminal kinase 1/2, p38MAPK, and ERK1/2. Using dominant-negative point mutations and chemical inhibitors, we identified that calcium-dependent proline-rich tyrosine kinase 2 specifically acts as a scaffold for a focal adhesion/cytoskeleton-dependent complex comprised of c-Src, Grb2, and mSos that translocates an ERK-activating signal to the nucleus. The locus of action of ERK was specifically mapped to early growth response-1 (Egr-1) DNA binding sites within the LH beta-subunit gene proximal promoter, which was also activated by p38MAPK, but not c-Jun NH2-terminal kinase 1/2. Egr-1 was confirmed as the transcription factor target of ERK and p38MAPK by blockade of protein expression, transcriptional activity, and DNA binding. We have identified a novel GnRH-activated proline-rich tyrosine kinase 2-dependent ERK-mediated signal transduction pathway that specifically regulates Egr-1 activation of the LH beta-subunit proximal gene promoter, and thus provide insight into the molecular mechanisms required for differential regulation of gonadotropin gene expression
Chloroplast Genome Yields Unusual Seven-Cluster Structure C
No full textWe studied the structuredness in a chloroplast genome of Siberian larch. The clusters in 63-dimensional space were identified with elastic map technique, where the objects to be clusterized are the different fragments of the genome. A seven-cluster structure in the distribution of those fragments reported previously has been found. Unlike the previous results, we have found the drastically other composition of the clusters comprising the fragments extracted from coding and non-coding regions of the genome
Symmetry in a Four-Cluster Triangle Structure of the Siberian Stone Pine (Pinus sibirica Du Tour) Transcriptome
No full textThe RNA isolated from three different tissues of Siberian stone pine—cambium, needles and buds—were sequenced and assembled for each tissue separately. [...
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