2,725 research outputs found
Norman Porteous as I Remember Him
No full textThis paper describes the period (1960-67) the author spent working with Norman Porteous in the department of Old Testament at New College, Edinburgh. He describes this as a time when Porteous was at the peak of his reputation as the foremost scholar of Old Testament Theology in Great Britain. However, the magnum opus that he might have been expected to produce at this point never appeared, in particular because the publication of von Rad’s Old Testament Theology made him realise that, with an already crowded schedule, he would not be able to devote sufficient time to be able to engage properly with such a major departure from the established ways of working in biblical theology. The paper does however give us insights into Porteous’ thinking on the subject around this time, based on a report of his Stone Lectures and from one-to-one interaction with the author
Porteous, A A, WX9414
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/411264Surname: PORTEOUS. Given Name(s) or Initials: A A. Military Service Number or Last Known Location: WX9414. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 33903.226976
Item: [2016.0049.43529] "Porteous, A A, WX9414
Excess Porteous, Coherent Porteous, and the Hyperelliptic Locus in M3
No full textIn the moduli space of curves of genus 3, the locus of hyperelliptic curves forms a divisor, that is a closed subscheme of codimension 1. J. Harris and I. Morrison compute an expression for the class of this divisor, in the Chow ring of the moduli space, using a map of vector bundles and by applying the Thom-Porteous formula to determine an expression for a certain degeneracy locus of this map. One would like to extend their idea in order to compute an expression for the divisor associated to the closure of the hyperelliptic locus, in the Chow ring of the moduli space of stable curves (of genus 3.) Recent work due to S. Diaz allows one to define the degeneracy class of a map between coherent sheaves, and gives explicit means for computing this class. Diaz uses his technique to partially extend the above mentioned computation, but he points out that in order to complete the computation one must combine his techniques with an Excess Thom-Porteous formula. This thesis completes this computation by combining the work of Diaz with this Excess Thom-Porteous formula
Porteous, Mitchell, and Braun department store, 1937
No full textExterior night view of Porteous, Mitchell, and Braun Department Store, 522 - 528 Congress Street, from northeast. The store building was photographed to highlight the display of electric Christmas lights. Porteous\u27 decorating tradition included decorating the canopy above the entrance with a row of Christmas trees.
Photo published in the Portland Press Herald, on 4 December 1937https://digitalcommons.portlandlibrary.com/pphnegs_images_business/1489/thumbnail.jp
DISC1 & GSK3β modulate PDE4 activity: functional integration of psychiatric associated signalling pathways
No full textFollowing the discovery of the DISC1 gene in 2000, subsequent research has led to
DISC1 becoming one of the most promising candidate genes for psychiatric disorders.
Acting as a scaffold protein, DISC1 has a large number of interacting proteins and is
involved in a series of intracellular signalling pathways. Amongst these binding proteins
are two enzymes, PDE4 and GSK3β, that were originally implicated in psychiatric
disease by virtue of their inhibition by psychoactive drugs. PDE4 enzymes are inhibited
by rolipram, which possesses anti-depressant and anti-psychotic activity, while GSK3β
is one of the major targets of lithium, a potent mood stabiliser. Both these enzymes are
intricately involved in the PI3K/AKT, cAMP, and MAPK signalling pathways, all of
which have a number of downstream outcomes with potential relevance to psychiatric
disorders. The Millar and Porteous laboratory had established that DISC1 modulates
PDE4 activity, but this predated awareness of GSK3 as another DISC1 interactor
whose binding site overlapped with that of PDE4. Since cAMP is a key regulator of
signalling pathways in the brain, I hypothesised that not only DISC1, but also GSK3β
may be involved in the regulation of PDE4 activity to control local cAMP levels and
gradients.
To investigate this hypothesis, I characterised SHSY5Y cells as a model for measuring
PDE4 activity, and performed a series of genetic and pharmacological manipulations on
this system. Inhibition of GSK3β resulted in a decrease of basal PDE4 activity that was
amplified by DISC1 overexpression. Wild type cells that were treated with forskolin
exhibited a significant increase in PDE4 activity, which was suppressed by GSK3β
inhibition and both overexpression and knockdown of DISC1. Further experiments
confirmed that none of these changes were a result of differences in PDE4 mRNA or
protein expression. Thus I have provided evidence that suggests tonic activation of
PDE4 by GSK3β and evidence for modulation of PDE4 activity by DISC1. I provide
evidence for the localisation of PDE4B & PDE4D with key psychiatric associated
receptors in structures resembling developing dendritic spines; furthermore, agonism of
NMDA receptors results in a significant increase in PDE4 activity in primary neurons.
These results are a simple demonstration of an emerging principle in psychiatric
research: that none of the signalling pathways implicated in psychiatric disease are
acting in isolation. There are likely to be multiple points of integration between these
pathways, with the demonstrated DISC1-GSK3β-PDE4 interaction forming one of these
points. My results add an important new element to the understanding of how the
DISC1 complex may regulate intracellular signalling in response to extracellular cues
Personal Papers (MS 80-0002)
No full textLetter from W. A. Porteous to J. E. Taylor discussing to meet Treasury regulations for his company in order to receive a Certificate of Authority from the Secretary of the Treasury
Norman Porteous and the Great War
No full textA brief account of Porteous’ war service with the Royal Scots Fusiliers, with whom he served in France in 1918
Norman Porteous: Germany and Scotland
No full textPorteous’ place as a leading proponent of Old Testament Theology can be traced back to the years he spent studying in Germany during the seminal period of the subject. This paper gives an account of his interaction with German biblical theology. It considers how he squared his early Barthianism with his later interest in the work of British theologians such as H. Wheeler Robinson. Also considered are his oppostion to Vischer; his engagement with Eichrodt and the question of normativity; his relation to von Rad and Heilsgeschichte and the subsequent crisis which caused him to reconsider much of his existing work. James Barr also gives an account of his own interaction with Porteous during a crisis point in his own career.[The full text of this article is not available online
044-03: Loading Porteous
No full textThis black and white photograph features three men standing on a wagon with a Porteous skeleton (also referred to as a Xiphactinus). Two boys are also on the wagon. One boy stands with the men, and the other sits on the wagon edge with a dog. The wagon is pulled by two horses. Another man sits on another horse to the right of the wagon.https://scholars.fhsu.edu/sternberg_album1/1180/thumbnail.jp
A review of flow-induced noise from finite wall-mounted cylinders
No full textAbstract not availableRic Porteous, Danielle J. Moreau, Con J. Doola
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