864 research outputs found
Training assessment: a source of key performance indexes for University
No full textIn most universities in Italy the students, to complete their academic curriculum, have
to perform a training period. This is an effect of the D.M. 509/99, aiming to a deep
reorganization of the whole structure of the higher education. In the case of
engineering university courses, it is often developed for a company. Although it is a
very useful experience for the student, the introduction of training in the student’s
curriculum does not involve a real change in the relationships between University and
industrial world. In this paper the status of the trainings in two engineering university
courses at the University of Pisa is shown. This report is used to highlight new
possibilities to be investigated to transform the training in a resource for the
universities. A proposal for the development of some KPIs (Key Performance Indexes)
useful to improve and make more effective the evaluation of University rating is also
described
L’effacement des dettes du failli : oui, mais quelles dettes ?
No full textL’article XX.173., § 1er, du Code de droit économique dispose que « si le failli est une personne physique, il sera libéré envers les créanciers du solde de ses dettes », hormis ses dettes alimentaires et celles qui résultent de son obligation de réparer un dommage lié au décès ou à l’atteinte à l’intégrité physique d’une personne qu’il a causé par sa faute. C’est la clôture de la faillite qui libère le failli (art. XX.173., § 2). L’effacement total ou partiel ne peut être refusé que si le failli a commis des fautes graves et caractérisées qui ont contribué à la faillite, ou a sciemment fourni des renseignements inexacts à l'occasion de l'aveu de la faillite ou ultérieurement aux demandes adressées par le juge-commissaire ou par le curateur (art. XX.173., § 3)
Optimization of Disassembly Sequences for Recycling of End-of-Life Products by Using a Colony of Ant-Like Agents
No full textAnt Colony Systems In Assembly Planning: A New Approach To Sequence Detection And Optimization
No full text
Numerical defect of circulating dendritic cell subsets and defective dendritic cell generation from monocytes of patients with advanced melanoma.
No full textThe behaviour of circulating dendritic cells (DCs) and DC generation from monocytes in melanoma patients during the progression of disease have not been described. We report a significant decrease in the absolute number of total DCs, which mainly affects plasmacytoid DCs in stage IV. Additionally, monocyte-DC generation is less efficient in advanced stages, resulting in DCs that exhibit increased phagocytic capacity, potentially indicating a less mature state. These findings elucidate aspects of basic tumour-mediated immunosuppression, which may have implications for immunotherapeutic approaches, suggesting that the selection of patients for immunotherapy should also be made on the basis of their immune status
The effects of zoledronate on monocyte-derived dendritic cells from melanoma patients differ depending on the clinical stage of the disease.
No full textZoledronic acid has shown indirect anticancer effects on angiogenesis, the tumor microenvironment and immune responses. Its immunological action is exerted, at least in part, via its modulating properties. The aim of this study was to investigate the in vitro effects of zoledronic acid on the dendritic cells of melanoma patients. Peripheral blood samples were collected from 26 patients with melanoma and 11 healthy donors. Dendritic cells were derived from purified monocytes, and zoledronic acid (ZA) was added on the first day of culture. The phenotype and function of the generated cells were evaluated by flow cytometry. The ZA-treated monocytes from patients with early-stage disease generated DCs characterized by reduced endocytic activity and increased allostimulatory capacity compared with the untreated samples, allowing restoration of the DC function observed in normal subjects. In contrast, the ZA-treated monocytes from patients at stage III generated cells with higher CD14 antigen expression and endocytosis than the untreated samples. Therefore, in melanoma patients, the in vitro ZA effects differ according to the progression of the disease. In addition, our preliminary results appear to suggest that ZA effects are also influenced by the expression of CD14 antigen, indicating that the DC phenotype together with clinical characteristics must be considered in the choice of patients to be treated with ZA. Our work focus on the effect of ZA on monocyte-derived DCs from melanoma patients, showing that the effects of therapeutic doses of this drug might be mediated at least in part by modulation of myeloid cell function
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