1,914 research outputs found
Dierlamm's Diphtheria & Croup Remedy
No full textTrade card advertising Dierlamm's Diphtheria & Croup Remedy, a remedy prepared by H. Dierlamm, Waterloo, Ont. This card has an 1882 copyright date. Title on verso: For diphtheria, croup and catarrh use Dierlamm's Diphtheria & Croup Remedy
Fluorescence In Situ Hybridization characterization of new translocation involving TEL (ETV6) in a wide spectrum of hematologic malignancies.
No full textCytogenetic and clinicobiological features of acute leukemia with stem cell phenotype: study of nine cases
No full textMorphologic, immunologic, cytogenetic, and clinical features were studied in 9 cases of acute undifferentiated leukemia (AUL). These patients were unclassifiable by FAB criteria, they were CD34+ and did not express myeloid- or lymphoid-associated antigens (CD13, CD33, CD14, CD15, CD61, CD19, CD10, CD22, CD7, CD2, CD5, CD3). Clonal abnormalities were seen in 8 of 9 cases. Del(5q) as the sole anomaly was observed in 3 cases; +13 was the primary change in 3 cases, and isolated trisomy 12 was found in 1 patient. A complex karyotype with trisomy 12q, in association with del 17p and trisomy 21q was detected in 1 case. One patient with 5q- relapsed with refractory anemia with excess of blasts; the presence of dysgranulopoiesis and a few blasts with possible monocytoid morphology in the remaining 2 patients point to a "myeloid nature" of these leukemias. Analysis of cytologic features in our 3 patients with +13, in combination with previously reported cases, suggests the occurrence of immature stem cell involvement with limited differentiation potential, possibly more along the myeloid than the lymphoid lineage. The significance of trisomy 12q in this subset of leukemia remains elusive; some clues of minimal differentiation towards the myeloid lineage in our cases are provided by positivity for the CD117 (c-kit) antigen and by relapse with acute myeloid leukemia without maturation (M1) in one patient. We conclude that, with presently available diagnostic techniques, AUL is a rare subset of leukemia, in which cytogenetic changes are confined to a few chromosomes, with prevalent involvement of 5q and of chromosomes 13 and 12. Chromosome findings may be of value in clinical practice, especially in those cases with "myeloid-oriented" karyotype
Characterisation of silicon sensor materials and designs for the CMS Tracker Upgrade
No full textDuring the high luminosity phase of the LHC (HL-LHC, starting around 2020) the inner tracking
system of CMS will be exposed to harsher conditions than the current system was designed for.
Therefore a new tracker is planned to cope with higher radiation levels and higher occupancies.
Within the strip sensor developments of CMS a comparative survey of silicon materials and technologies
is being performed in order to identify the baseline material for the future tracker. Hence,
a variety of materials (float-zone, magnetic Czochralski and epitaxially grown silicon with thicknesses
from 50μm to 320μm as p- and n-type) has been processed at one company (Hamamatsu
Photonics K.K.), irradiated (proton, neutron and mixed irradiations up to 1:5 1015 neq=cm2 and
beyond) and tested under identical conditions. The wafer layout includes a variety of devices to
investigate different aspects of sensor properties like simple diodes, test-structures, small strip
sensors and a strip sensor array with varying strip pitch and strip width. This paper presents the
current status and results of this campaign
CMS silicon tracker: milestone 200
No full textThe tracker of CMS will fully consist of silicon micro-strip and pixel sensors. Building a detector with 210 m/sup 2/ sensor surface in about 3 years requires a tightly controlled construction schedule. All different aspects of the production are exercised within a pre- production of 200 modules (Milestone 200) to identify and eliminate possible bottlenecks and to test the complete electronic chain. The quality, process stability and radiation hardness of the silicon sensors will be permanently monitored. Automatic assembly procedure and industrial bonding machines will guarantee a fast and reliable construction. All modules will be tested for signal, noise and pedestals at room temperature and operation temperature of -10 degrees C. Quality assurance of the Milestone 200 sensors and modules including irradiation and stability tests are presented. (6 refs)
Irradiation qualification of CMS silicon tracker components with protons
No full textThe tracking system of the CMS experiment at the LHC collider (CERN) is based on silicon micro-strip detectors. They will be exposed to an equivalent fluence of up to 1.6 multiplied by 10**1**4n (1 MeV)/cm**2 during 10 years of operation. The survival of the sensors in such a radiation environment depends strongly on the sensor design and on the choice of appropriate material. During production we have to verify not only the current quality of the delivered sensors (optical and electronic inspection) but also their radiation hardness. After irradiation to the exposed fluence plus a safety factor, the quality of bulk and surface parameters is verified. Required protocol, measurements and results are presented
Novel fusion of the MALT1/MLT and MAP4 genes detected in a diffuse large B-cell lymphoma
No full textSilicon detectors for the SLHC: An overview of recent RD50 results
No full textIt is foreseen to significantly increase the luminosity of the Large Hadron Collider (LHC) at CERN around 2018 by upgrading the LHC towards the SLHC (Super-LHC). Due to the radiation damage to the silicon detectors used, the physics experiments will require new tracking detectors for SLHC operation. All-silicon central trackers are being studied in ATLAS, CMS and LHCb, with extremely radiation hard silicon sensors for the innermost layers. The radiation hardness of these new sensors must surpass the one of LHC detectors by roughly one order of magnitude. Within the CERN RD50 collaboration, a massive R&D; program is underway to develop silicon sensors with sufficient radiation tolerance. We will report on recent results obtained by RD50 from tests of several detector technologies and silicon materials at radiation levels corresponding to SLHC fluences. Based on these results, we will give recommendations for the silicon detector technologies to be used at the different radii of SLHC tracking systems
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