1,742,545 research outputs found
In vivo PET quantification of the dopamine transporter in rat brain with [¹⁸F]LBT-999.
Get PDFINTRODUCTION:
We examined whether [(18)F]LBT-999 ((E)-N-(4-fluorobut-2-enyl)2β-carbomethoxy-3β-(4'-tolyl)nortropane) is an efficient positron emission tomography (PET) tracer for the quantification of the dopamine transporter (DAT) in the healthy rat brain.
METHODS:
PET studies were performed using several experimental designs, i.e. test-retest, co-injection with different doses of unlabelled LBT, displacement with GBR12909 and pre-injection of amphetamine.
RESULTS:
The uptake of [(18)F]LBT-999 confirmed its specific binding to the DAT. The non-displaceable uptake (BP(ND)) in the striatum, between 5.37 and 4.39, was highly reproducible and reliable, and was decreased by 90% by acute injection of GBR12909. In the substantia nigra/ventral tegmental area (SN/VTA), the variability was higher and the reliability was lower. Pre-injection of amphetamine induced decrease of [(18)F]LBT-999 BP(ND) of 50% in the striatum.
CONCLUSIONS:
[(18)F]LBT-999 allows the quantification of the DAT in living rat brain with high reproducibility, sensitivity and specificity. It could be used to quantify the DAT in rodent models, thereby allowing to study neurodegenerative and neuropsychiatric diseases
999 and Original Fetish concert flier, Marble Bar, Baltimore, Maryland, April 23, 1980
No full textFlier promoting concert by the English punk band 999 and the Washington, D.C. area rock band Original Fetish, The concert occurred on April 23, 1980 at the Marble Bar in Baltimore, Maryland
999 concert flier, University of Maryland, College Park, Maryland - October 13, 1981
No full textA promotional flier for a concert by the British punk band 999 and the Los Angeles punk band the Alley Cats. The concert occurred in the Stamp Student Union's Grand Ballroom at the University of Maryland in College Park on October 13, 1981
[Southern Pacific, No. 999]
No full textNegative sleeve: [handwritten] Southern Pacific Lines - Texas & New Orleans R.R. No. 999 2-10-2 type F-1 class. Envelope: [handwritten] S.P. T. & N.O. No. 999 2-10-2 type
999 CONVOCATORIAS
No full textCONVOCATORIAS para Subdirectores Académico; Servicios Educativos e Integración Social; Administrativo; Académico y de Investigación; de Innovación y Desarrollo Tecnológico; Directores y Jefe de la Sección de Estudios de Posgrado e Investigació
Las 999 mujeres de Auschwitz
No full textTraducciónHistoria de las primeras 999 mujeres eslovacas que ocuparon el campo de concentración de Auschwitz.History of the first 999 Slovak women who occupied the Auschwitz concentration camp.info:eu-repo/semantics/publishedVersio
INVESTIGATION OF EXCITED STATES OF ODD-ODD NUCLEI OF *999*996Rh AND *999*998Rh IN (p, n gamma ) REACTION
No full textData about properties of low-laying states of *999*996Rh and *999*998Rh have been used for the comparison with calculations on the statistic theory of Khauzer - Feshbakh. The revealed differences between theoretical calculations and experiments in sections of excitations of levels 1+ may lead to the refinement of the method of Khauzed-Feshbakh for the case of small moments. Spectrums of gamma -beams in *999*996Ru (p, n gamma ) *999*996Rh and *999*998Ru (p, n gamma ) *999*998Rh reactions have been measured for the first time. The position of earlier unknown excited levels has been established in *999*996Rh and *999*998Rh nucleiAvailable from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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