1,741,734 research outputs found
dph06_adult_YA-947
No full textTIFF sequence of interaction YA-947 (6 days post-hatch fish targeting an adult copepod)
Production of photinos in e<SUP>+</SUP>e<SUP>-</SUP>→γγ˜γ˜
No full textWe discuss the production of photinos in e+e-→γγ˜γ˜ for arbitrary photino and scalar-electron masses. We present detailed cross sections as a function of various parameters, as well as a discussion of the background coming from e+e-→γvv̅. We conclude from our analysis that it may be possible to observe the signatures of supersymmetry in this process only for scalar-electron and photino masses up to 40 and 5 GeV, respectively, and for √s≲40 GeV. Otherwise the process e+e-→γvv̅ becomes a dominant process
Relativistic QPC model for reduced V → Pγ, P → γγ, etc. decays and enhanced E.M. tadpoles
No full textCertain relativization prescriptions for the quark pair creation (QPC) model are found to lead to an understanding of the connected problems of the reduced radiative decays and enhanced e.m. mass differences within a unified framework. In particular, we find excellent agreement with most V → Pγ, P → Vγ and P → γγ as well as η → 3π, η → π0γγ decays, all without free parameters
Oncolytic adenovirus dl922-947 targets the DNA damage signaling pathway and enhances the effects of radiation therapy
No full textReplication selective oncolytic viruses (OVs) are a rapidly expanding
therapeutic platform for cancer treatment. OVs are characterized by genetic
alterations that ablate critical viral protein functions essential for viral
replication in normal cells, but non-essential in tumor cells, thus targeting viral
replication to tumor cells.
dl1520 was the first oncolytic virus described, and we have demonstrated that
dl1520 is effective against anaplastic thyroid carcinoma (ATC) cells and tumor
xenografts; its antineoplastic effects are enhanced by paclitaxel, doxorubicin,
lovastatin and ionising radiation. We have also shown that the second
generation oncolytic adenovirus dl922-947 possesses a greater antitumor effect
than dl1520 against ATC cells, and that the anti-VEGF monoclonal antibody,
Bevacizumab, increased the effects of dl922-947 by improving viral
distribution within the tumor mass. Furthermore, we have also shown that
AZD1152, a selective Aurora B kinase inhibitor, negatively affects the growth
of anaplastic thyroid carcinoma cells and enhances the effects of oncolytic
virus dl922-947.
So far, preclinical and clinical studies have clearly shown the antineoplastic
potential of oncolytic viruses, at least for local treatment, but have also
highlighted the need to find associations that could improve their activity.
Association of viruses with specific combinations, not only able to directly kill
tumor cells but also to increase viral oncolytic activity, would represent a
powerful therapeutic tool for the treatment of human neoplasia, in particular for
diseases lacking of effective treatment.
The main treatment of ATC consists of irradiation plus chemotherapeutic
drugs. In order to identify novel treatment able to enhance the effects of OVs, I
have evaluated the effects of ionising radiation in combination with dl922-947,
focusing my attention on which type of cell death was activated in the
combined treatment. Moreover, I have studied the effects of dl922-947 on the
DNA damage response pathway and I have also evaluated the effects of an
ATM inhibitor on dl922-947’s activity
Bethe-Salpeter basis for quark-pair-creation model: understanding of VPP, VPγ, and Pγγ couplings
No full textA Bethe-Salpeter harmonic-oscillator framework, developed recently for qq̅ mesons in the instantaneous (null-plane) approximation, is employed for the construction of MMM couplings (M=P or V) through quark-loop diagrams. The resulting structure of the matrix elements exhibits the central feature of the quark-pair-creation model, that is, a multiplicative structure for the orbital and spin wave functions of all three qq̅ states involved, together with a couple of essential kinematical factors (but only in the numerator) as part of the field-theoretic result. The model is illustrated through two typical meson couplings involving equal-mass quarks, ρ→ππ and ω→ρπ, as well as through the two electromagnetic processes ω→γπ0 and π0→γγ. The ρ→ππ and ω→γπ0 widths (via direct γ coupling) come out as 142.7 MeV and 888 keV, respectively, with no adjustable parameters. The ω→γπ0 matrix element also agrees to within 1%, with that obtained from the corresponding ωρπ coupling through vector-meson-dominance (VMD) substitution. The π0→γγ width (7.7 eV) agrees excellently with experiment when it is deduced from ωρπ coupling via double VMD substitution, but the corresponding amplitude obtained from direct γ coupling is only about half the experimental value. Theoretical reasons are given for this apparent paradox
Stereoselective syntheses of γ-alkyl (aryl)-α,β-dihydroxy-γ-butyrolactones and naturally occurring lipid guggultetrol
No full textγ-Oxo-butyramides derived from tartaric acid serve as excellent precursors for the synthesis of γ-alkyl (aryl)-α,β-dihydroxy-γ-butyrolactones and for the synthesis of tetrols containing three contiguous stereogenic centres. The methodology presented here is general for the synthesis of γ-alkyl (aryl)-α,β-dihydroxy-γ-butyrolactones. Utility of the chiral building block was demonstrated by the synthesis of naturally occurring lipid guggultetrol
Eikonalised minijet model analysis of σ<SUB>γγ</SUB><SUP>inel</SUP>
No full textWe study the theoretical predictions for the total inelastic γγ cross-sections, with an emphasis on the eikonalised minijet model (EMM). In the context of the EMM, we discuss a new ansatz for the overlap function involving the photons. We discuss the dependence of the EMM predictions on various input parameters as well as predictions for σγγinel from a simple extension of the Regge Pomeron Exchange model. We then compare both with the recent LEP data
σ<SUP>tot</SUP><SUB>eeγγ</SUB> at e<SUP>+</SUP>e<SUP>-</SUP> colliders
No full textIn this talk I briefly summarize different models for σtot2γ(e+e-→γγ→hadrons) and contrast model predictions with the data. I will then discuss the capability of the future e+e- and γγ colliders to distinguish between various models and end with an outlook for future work
Valle dello Jaγnob
No full textObiettivo del progetto “Valle dello Jaγnob” eĚ€ lo studio di una delle etnie piuĚ€ importanti della Via della Seta, i cui discendenti sopravvivono ancor oggi in una remota valle dell’Asia Centrale intagliata dal fiume Jaγnob. La loro parlata, la lingua jaγnobī, eĚ€ l’ultima varietaĚ€ ancora vivente, sebbene in forma assai residuale, dell’antico sogdiano, la lingua franca del commercio e degli scambi culturali lungo il multiforme tracciato della Via della Seta, crocevia e luogo di incontro tra molti Orienti e Occidenti.
L’obiettivo saraĚ€ perseguito attraverso un’indagine sul campo di carattere etnolinguistico, valutando con appositi questionari lo stato di conservazione della lingua, registrando racconti e documenti orali e soprattutto comparando le due varianti dialettali che, secondo la manualistica del secolo scorso, si distinguono in jaγnobī occidentale e jaγnobī orientale.
È inoltre nostro scopo precipuo riscontrare una serie di consuetudini folkloristiche locali che, nonostante il processo di islamizzazione, lasciano trasparire un sostrato di religiosità iranica arcaica, grosso modo riconducibile a certi filoni della tradizione zoroastriana.
Intendiamo infine effettuare un riscontro del DNA degli jaγnobī e dei tadzĚŚiki che abitano nelle zone limitrofe, non solo per circonstanziare meglio i caratteri antropologici delle etnie presenti in Valle, ma anche per verificare le eventuali peculiaritaĚ€ genetiche che hanno reso possibile la sopravvivenza umana e l’adattamento psico-fisico in un territorio cosiĚ€ aspro ed elevato (3.000 m s.l.m.)
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