1,728,833 research outputs found
Reliability of steel beams designed by Brazilian code NBR 8800.
No full textO estudo da confiabilidade estrutural se relaciona com a avaliação da probabilidade de violação dos estados limites para um sistema estrutural. Uma vez definidos pelo projetista os estados limites relevantes ao sistema estrutural, deve-se calcular o nível de segurança com respeito a esses estados. Nesse trabalho, é feito um estudo do nível de confiabilidade de vigas de perfis I laminados para o estado limite de flexão, projetadas segundo a Norma Brasileira NBR 8800 (1986) e seu projeto de revisão NBR 8800 (2003) através do método de confiabilidade de primeira ordem (FORM). São apresentados gráficos das variações do índice de confiabilidade (β) em função do índice de esbeltez e, em seguida, é apresentada uma metodologia para uniformizar a confiabilidade, no domínio de um estado limite, através da adoção de procedimentos de correção do coeficiente de resistência.The study of structural reliability is related to the assessment the probability of limit state violations in a structural system. Once the designer defines the relevant limits of the structural system, the safety level of these limits must be evaluated. A reliability study of hot-rolled I beams in a flexure limited state, designed in accordance with Brazilian Code NBR 8800 (1986) and draft of new NBR 8800 (2003) was done by the First Order Reliability Method (FORM). Variations of the reliability index (β) versus slenderness are plotted, and finally a methodology to obtain uniform reliability in a limitedstate domain by adopting correction procedures for the strength factor is presented
Reliability of steel beams designed by Brazilian code NBR 8800.
No full textO estudo da confiabilidade estrutural se relaciona com a avaliação da probabilidade de violação dos estados limites para um sistema estrutural. Uma vez definidos pelo projetista os estados limites relevantes ao sistema estrutural, deve-se calcular o nível de segurança com respeito a esses estados. Nesse trabalho, é feito um estudo do nível de confiabilidade de vigas de perfis I laminados para o estado limite de flexão, projetadas segundo a Norma Brasileira NBR 8800 (1986) e seu projeto de revisão NBR 8800 (2003) através do método de confiabilidade de primeira ordem (FORM). São apresentados gráficos das variações do índice de confiabilidade (β) em função do índice de esbeltez e, em seguida, é apresentada uma metodologia para uniformizar a confiabilidade, no domínio de um estado limite, através da adoção de procedimentos de correção do coeficiente de resistência.The study of structural reliability is related to the assessment the probability of limit state violations in a structural system. Once the designer defines the relevant limits of the structural system, the safety level of these limits must be evaluated. A reliability study of hot-rolled I beams in a flexure limited state, designed in accordance with Brazilian Code NBR 8800 (1986) and draft of new NBR 8800 (2003) was done by the First Order Reliability Method (FORM). Variations of the reliability index (β) versus slenderness are plotted, and finally a methodology to obtain uniform reliability in a limitedstate domain by adopting correction procedures for the strength factor is presented
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Metabolic disposition of H3B-8800, an orally available small-molecule splicing modulator, in rats, monkeys, and humans
No full textH3B-8800, a novel orally available modulator of the SF3b complex, which potently and preferentially kills spliceosome-mutant tumor cells, is in clinical development for the treatment of advanced myeloid malignancies. We characterized the pharmacokinetics, metabolism and disposition of H3B-8800 in rats, monkeys and humans.In vitro, H3B-8800 is a substrate of CYP3A4/5, flavin-containing monooxygenases (FMOs) and P-glycoprotein (P-gp), and showed a favorable drug–drug interaction profile as a perpetrator.Following oral dosing of 14C-H3B-8800 in bile-duct cannulated SD rats, 54.7% of the dosed radioactivity was excreted in the bile, with less found in feces (36.8%). The low amount in urine (3.7%), suggests that renal elimination is a minor pathway of clearance for H3B-8800.In Long-Evans rats, radioactivity derived from 14C-H3B-8800 was rapidly absorbed, with the highest distribution in the ocular, metabolic/excretory, and gastrointestinal tract tissues. No radioactivity was detected in the central nervous system.Seven metabolites were observed in human plasma following 4 daily doses of 40 mg H3B-8800. H3B-68736 (N-desmethyl), H3B-77176 (N-oxide), and unchanged H3B-8800 were the prominent components in human plasma, at 27.3%, 18.1%, and 33.2%, respectively, of the total drug-related material in a pooled AUC0–24h sample. The same 7 metabolites were observed in monkey plasma. H3B-8800, a novel orally available modulator of the SF3b complex, which potently and preferentially kills spliceosome-mutant tumor cells, is in clinical development for the treatment of advanced myeloid malignancies. We characterized the pharmacokinetics, metabolism and disposition of H3B-8800 in rats, monkeys and humans. In vitro, H3B-8800 is a substrate of CYP3A4/5, flavin-containing monooxygenases (FMOs) and P-glycoprotein (P-gp), and showed a favorable drug–drug interaction profile as a perpetrator. Following oral dosing of 14C-H3B-8800 in bile-duct cannulated SD rats, 54.7% of the dosed radioactivity was excreted in the bile, with less found in feces (36.8%). The low amount in urine (3.7%), suggests that renal elimination is a minor pathway of clearance for H3B-8800. In Long-Evans rats, radioactivity derived from 14C-H3B-8800 was rapidly absorbed, with the highest distribution in the ocular, metabolic/excretory, and gastrointestinal tract tissues. No radioactivity was detected in the central nervous system. Seven metabolites were observed in human plasma following 4 daily doses of 40 mg H3B-8800. H3B-68736 (N-desmethyl), H3B-77176 (N-oxide), and unchanged H3B-8800 were the prominent components in human plasma, at 27.3%, 18.1%, and 33.2%, respectively, of the total drug-related material in a pooled AUC0–24h sample. The same 7 metabolites were observed in monkey plasma.</p
H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers
No full textGenomic analyses of cancer have identified recurrent point mutations in the RNA splicing factor-encoding genes SF3B1, U2AF1, and SRSF2 that confer an alteration of function(1-6). Cancer cells bearing these mutations are preferentially dependent on wild-type (WT) spliceosome function(7-11), but clinically relevant means to therapeutically target the spliceosome do not currently exist. Here we describe an orally available modulator of the SF3b complex, H3B-8800, which potently and preferentially kills spliceosome-mutant epithelial and hematologic tumor cells. These killing effects of H3B-8800 are due to its direct interaction with the SF3b complex, as evidenced by loss of H3B-8800 activity in drug-resistant cells bearing mutations in genes encoding SF3b components. Although H3B-8800 modulates WT and mutant spliceosome activity, the preferential killing of spliceosome-mutant cells is due to retention of short, GC-rich introns, which are enriched for genes encoding spliceosome components. These data demonstrate the therapeutic potential of splicing modulation in spliceosome-mutant cancers
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Dataset of 8800 animal × seed interactions
No full text<p>8800 unique animal × seed interactions and their corresponding animal body masses, animal categories, seed volumes, fruit types, research sources and references.</p><p><br></p><p>Paper:</p><p>A mammoth mouthful? A test of the idea that larger animals ingest larger seeds</p><p>SC Chen, AT Moles</p><p>Global Ecology and Biogeography 24 (11), 1269-1280</p><p>https://doi.org/10.1111/geb.12346<br></p
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