1,723,591 research outputs found
More eyes on COVID-19 : a legal perspective: the unforeseen social impacts of regulatory interventions
Get PDFCITATION: Madonsela, T. 2020. More eyes on COVID-19 : a legal perspective: the unforeseen social impacts of regulatory interventions. South African Journal of Science, 116(7/8), Art. #8527, doi:10.17159/sajs.2020/8527.The original publication is available at http://sajs.co.zaNo abstract available.https://www.sajs.co.za/article/view/8527Publisher's versio
MK-8527 is a novel inhibitor of HIV-1 reverse transcriptase translocation with potential for extended-duration dosing.
No full textNucleoside reverse transcriptase translocation inhibitors (NRTTIs) are potent antiretroviral agents that block HIV replication. A comprehensive lead optimization campaign was undertaken to develop a novel long-acting NRTTI with the potential for extended-duration dosing for HIV prophylaxis. Broad exploration of nucleoside structure-activity relationship (SAR), leveraging ribose core, periphery, and nucleobase modifications, along with systematic progression of compounds of interest through key in vitro and in vivo studies led to the discovery of MK-8527. MK-8527 is a novel deoxyadenosine analog that is phosphorylated intracellularly to its active triphosphate (TP) form, which inhibits reverse transcription. Iron footprinting and primer extension assays demonstrated that MK-8527-TP inhibits translocation of reverse transcriptase on the primer and template, and this inhibition allows for both immediate and delayed chain termination of reverse transcription. MK-8527 inhibits viral replication in human peripheral blood mononuclear cells (PBMCs), with a half maximal inhibitory concentration (IC50) of 0.21 nM. The pharmacokinetic (PK) profile of MK-8527 in rats and rhesus monkeys was characterized by low-to-moderate clearance and volume of distribution, with good oral absorption (57% and 100% in rats and monkeys, respectively). Following oral administration of MK-8527 to monkeys, MK-8527-TP exhibited an intracellular half-life of approximately 48 h in PBMCs, significantly longer than the apparent plasma half-life of the parent compound (approximately 7 h). MK-8527 and MK-8527-TP demonstrated favorable in vitro off-target profiles, with IC50 values of ≥95 µM against human DNA polymerases tested, and no off-target activities at 10 μM against a panel of 114 enzyme and receptor binding assays. Collectively, the potent antiretroviral activity and favorable preclinical PK and off-target profiles make MK-8527 an attractive clinical candidate, and it is currently in clinical trials for once-monthly oral HIV-1 pre-exposure prophylaxis
Linked collectors and determiners for: Review of some species groups of the genus Oospila Warren, with descriptions of nine new species (Lepidoptera: Geometridae: Geometrinae).
No full textNatural history specimen data linked to collectors and determiners held within, "Review of some species groups of the genus Oospila Warren, with descriptions of nine new species (Lepidoptera: Geometridae: Geometrinae)". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/4622feb8-93b3-4a09-8527-4f71d6cda3cf">https://bionomia.net/dataset/4622feb8-93b3-4a09-8527-4f71d6cda3cf</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/4622feb8-93b3-4a09-8527-4f71d6cda3cf">https://gbif.org/dataset/4622feb8-93b3-4a09-8527-4f71d6cda3cf</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: HERBAM herbarium - Herbário da Amazônia Meridional - Herbário Virtual REFLORA.
No full textNatural history specimen data linked to collectors and determiners held within, "HERBAM herbarium - Herbário da Amazônia Meridional - Herbário Virtual REFLORA". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/1a699020-5c6b-4d91-8527-eb464b153a22">https://bionomia.net/dataset/1a699020-5c6b-4d91-8527-eb464b153a22</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/1a699020-5c6b-4d91-8527-eb464b153a22">https://gbif.org/dataset/1a699020-5c6b-4d91-8527-eb464b153a22</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: Limonia crane flies (Diptera: Limoniidae) of Korea.
No full textNatural history specimen data linked to collectors and determiners held within, "Limonia crane flies (Diptera: Limoniidae) of Korea". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/c70ca02d-ec00-4eaf-8527-d60d24db3f4c">https://bionomia.net/dataset/c70ca02d-ec00-4eaf-8527-d60d24db3f4c</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/c70ca02d-ec00-4eaf-8527-d60d24db3f4c">https://gbif.org/dataset/c70ca02d-ec00-4eaf-8527-d60d24db3f4c</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: Review of some species groups of the genus Oospila Warren, with descriptions of nine new species (Lepidoptera: Geometridae: Geometrinae).
No full textNatural history specimen data linked to collectors and determiners held within, "Review of some species groups of the genus Oospila Warren, with descriptions of nine new species (Lepidoptera: Geometridae: Geometrinae)". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/4622feb8-93b3-4a09-8527-4f71d6cda3cf">https://bionomia.net/dataset/4622feb8-93b3-4a09-8527-4f71d6cda3cf</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/4622feb8-93b3-4a09-8527-4f71d6cda3cf">https://gbif.org/dataset/4622feb8-93b3-4a09-8527-4f71d6cda3cf</a>. Formatted as a Frictionless Data package
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
- …
