1,724,534 research outputs found
Danthron induced apoptosis through mitochondria- and caspase-3-dependent pathways in human brain glioblastoma multiforms GBM 8401 cells
No full text[[abstract]]Danthron (1,8-dihydroxyanthraquinone), is one of component from Rheum palmatum L. (Polygonaceae), has been shown several biological activities but did not show to induce apoptosis in human brain tumor cells. The aim of this study is to investigate the mechanisms by danthron for the induction of apoptotic potential on human brain glioblastoma multiforms GBM 8401 cell line. Danthron showed a marked concentration- and time-dependent inhibition of GBM 8401 cell viability and induced apoptosis in a dose-and time-dependent manner. There was an attenuation of mitochondrial membrane potential (DeltaPsi(m)) with the alterations of Bcl-2/Bax protein ratio in GBM 8401 cells, indicating the participation of a mitochondria-related mechanism. Pretreatment of a caspase-8 inhibitor (Z-IETD-FMK), caspase-9 inhibitor (Z-LEHD-FMK) and caspase-3 inhibitor (Z-DEVE-FMK) significantly increased the viable of GBM 8401 cells implied that the participations of caspases. Western blotting analysis also showed the activation of initiator caspase-8 and caspase-9, and executor caspase-3 in GBM 8401 cells. Meanwhile, danthron also promoted the generation of reactive oxygen species (ROS) and cytosolic Ca(2+) in GBM 8401 cells. Taken together, our data showed that danthron induced apoptosis in GBM 8401 cells through mitochondria-related and caspase-related pathways, and it may be further evaluated as a chemotherapeutic agent for human brain cancer
Danthron Induced Apoptosis Through Mitochondria- and Caspase-3-Dependent Pathways in Human Brain Glioblastoma Multiforms GBM 8401 Cells
No full text[[abstract]]Danthron (1,8-dihydroxyanthraquinone), is one of component from Rheum palmatum L. (Polygonaceae), has been shown several biological activities but did not show to induce apoptosis in human brain tumor cells. The aim of this study is to investigate the mechanisms by danthron for the induction of apoptotic potential on human brain glioblastoma multiforms GBM 8401 cell line. Danthron showed a marked concentration- and time-dependent inhibition of GBM 8401 cell viability and induced apoptosis in a dose-and time-dependent manner. There was an attenuation of mitochondrial membrane potential (Delta I (m) ) with the alterations of Bcl-2/Bax protein ratio in GBM 8401 cells, indicating the participation of a mitochondria-related mechanism. Pretreatment of a caspase-8 inhibitor (Z-IETD-FMK), caspase-9 inhibitor (Z-LEHD-FMK) and caspase-3 inhibitor (Z-DEVE-FMK) significantly increased the viable of GBM 8401 cells implied that the participations of caspases. Western blotting analysis also showed the activation of initiator caspase-8 and caspase-9, and executor caspase-3 in GBM 8401 cells. Meanwhile, danthron also promoted the generation of reactive oxygen species (ROS) and cytosolic Ca2+ in GBM 8401 cells. Taken together, our data showed that danthron induced apoptosis in GBM 8401 cells through mitochondria-related and caspase-related pathways, and it may be further evaluated as a chemotherapeutic agent for human brain cancer
Replacement of soyabean meal with dehydrated lupin seeds in pig diets
No full text120 pigs, 11.6 kg, were fed on barley-based diets in which 0, 25, 50, 75 or 100% of supplementary soyabean meal protein was replaced by dehydrated lupin seed (Lupinus albus cultivar Ultra). Starter pigs (10-20 kg) given the 25% lupin diet (25% L) had similar growth rates and consumed more feed (P http://upei-resolver.asin-risa.ca?sid=SP:CABI&id=pmid:&id=&issn=0377-8401&isbn=&volume=43&issue=1%2f2&spage=77&pages=77-85&date=1993&title=Animal%20Feed%20Science%20and%20Technology&atitle=Replacement%20of%20soyabean%20meal%20with%20dehydrated%20lupin%20seeds%20in%20pig%20diets.&aulast=Donovan&pid=%3Cauthor%3EDonovan%2c%20B%20C%3bMcNiven%2c%20M%20A%3bLunen%2c%20T%20A%20van%3bAnderson%2c%20D%20M%3bMacLeod%2c%20J%20A%3C%2Fauthor%3E%3CAN%3E19931464343%3C%2FAN%3E%3CDT%3EJournal%20article%3C%2FDT%3
Protein quality of two cultivars of lupin seeds evaluated in weanling rats
No full textFor 3 weeks, 128 male Sprague-Dawley rats, 3 weeks old, were fed on diets containing no protein, casein, soyabean meal, roasted or raw soyabeans, or sweet white lupin (Lupinus albus) cultivar Primorski or Ultra without or with 0.1% lysine or 0.2% methionine. Relative net protein ratio (RNPR) (casein = 100%) of lupins Primorski and Ultra supplemented with methionine was 81.1 and 79.1%, respectively, and was higher than that for roasted soyabeans (71.4%) (P http://upei-resolver.asin-risa.ca?sid=SP:CABI&id=pmid:&id=&issn=0377-8401&isbn=&volume=33&issue=1-2&spage=87&pages=87-95&date=1991&title=Animal%20Feed%20Science%20and%20Technology&atitle=Protein%20quality%20of%20two%20cultivars%20of%20lupin%20seeds%20evaluated%20in%20weanling%20rats.&aulast=Donovan&pid=%3Cauthor%3EDonovan%2c%20B%20C%3bMcNiven%2c%20M%20A%3bMacLeod%2c%20J%20A%3bAnderson%2c%20D%20M%3C%2Fauthor%3E%3CAN%3E19911432205%3C%2FAN%3E%3CDT%3EJournal%20article%3C%2FDT%3
Danthron Induced Apoptosis Through Mitochondria- and Caspase-3-Dependent Pathways in Human Brain Glioblastoma Multiforms GBM 8401 Cells
No full textDanthron (1,8-dihydroxyanthraquinone), is one of component from Rheum palmatum L. (Polygonaceae), has been shown several biological activities but did not show to induce apoptosis in human brain tumor cells. The aim of this study is to investigate the mechanisms by danthron for the induction of apoptotic potential on human brain glioblastoma multiforms GBM 8401 cell line. Danthron showed a marked concentration- and time-dependent inhibition of GBM 8401 cell viability and induced apoptosis in a dose-and time-dependent manner. There was an attenuation of mitochondrial membrane potential (Delta I (m) ) with the alterations of Bcl-2/Bax protein ratio in GBM 8401 cells, indicating the participation of a mitochondria-related mechanism. Pretreatment of a caspase-8 inhibitor (Z-IETD-FMK), caspase-9 inhibitor (Z-LEHD-FMK) and caspase-3 inhibitor (Z-DEVE-FMK) significantly increased the viable of GBM 8401 cells implied that the participations of caspases. Western blotting analysis also showed the activation of initiator caspase-8 and caspase-9, and executor caspase-3 in GBM 8401 cells. Meanwhile, danthron also promoted the generation of reactive oxygen species (ROS) and cytosolic Ca(2+) in GBM 8401 cells. Taken together, our data showed that danthron induced apoptosis in GBM 8401 cells through mitochondria-related and caspase-related pathways, and it may be further evaluated as a chemotherapeutic agent for human brain cancer
Nahbereichsfotogrammetrie im Fahrzeugbau 1. Grundlagen und Anwendungsmoeglichkeiten
No full textTIB: RN 4541 (8401) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman
16. Jahresbericht des Rechenzentrums der Ruhr-Universitaet Bochum 1.1.-31.12.1983
No full textTIB: RN 6655 (8401) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman
California Poll: 8401 -- February 2-9, 1984
No full textThe Field Poll, established in 1945 as The California Poll by Mervin Field, has operated continuously as an independent, non-partisan, media-sponsored public opinion news service. Each year the Field Polls cover a wide range of political and social topics examining California public opinion. Continuing measures are made of voter support for leading political figures vying for major state and federal offices, job ratings of important political figures and reactions to significant political events. Voter awareness, understanding and predispositions of major campaign issues and salient statewide ballot propositions are also tracked over time. For poll 8401 N=1511
Linked collectors and determiners for: International records of herpetofauna published in the British Herpetological Society's journals.
No full textNatural history specimen data linked to collectors and determiners held within, "International records of herpetofauna published in the British Herpetological Society's journals". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/78e2c7a4-4ee4-40bf-8401-e45be3c004ba">https://bionomia.net/dataset/78e2c7a4-4ee4-40bf-8401-e45be3c004ba</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/78e2c7a4-4ee4-40bf-8401-e45be3c004ba">https://gbif.org/dataset/78e2c7a4-4ee4-40bf-8401-e45be3c004ba</a>. Formatted as a Frictionless Data package
- …
