1,725,623 research outputs found
Study on the antidiabetic mechanism of a shark liver peptide, S-8300, in alloxan-induced diabetes
No full textAbstract
Objectives
The aim was to evaluate the antidiabetic mechanism of S-8300 in alloxandiabetic mice.
Methods
Diabetes was induced by a single intravenous injection of alloxan (60 mg/kg). The effects of S-8300 on diabetic mice were investigated by observing the change in fasting plasma glucose, detecting Fas mRNA by reverse transcriptase-polymerase chain reaction, Fas protein expression in the pancreas by immunohistochemistry and Western blot, and the DNA fragmentation pattern forming a ladder by electrophoresis.
Key findings
A significant decrease in fasting plasma glucose was observed, and Fas mRNA and Fas protein expression in the pancreas were attenuated in diabetic mice treated with S-8300. Treatment with S-8300 also attenuated DNA ladder formation.
Conclusions
The results suggest that S-8300 inhibits Fas protein-mediated apoptosis of pancreas cells.
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[Reading Company., Engine Drawing Card, Sketch No. 8300]
No full textThis engine drawing card was created for the Reading Company, Class 8-42E. Section J-8E. Sketch 8300. Copy Spec. 35D18
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Un lugar para decir. (8300), historia del surgimiento de un periódico de Neuquén
Get PDFAbstract (8300) is the post code that makes reference to an exact point of a country for the mail to get to its right destination, and it is also the name of a newspaper in Neuquén, whose origin dates back to December 2003 when its first printed edition came out. Within which social and political relationships was (8300) born as a graphic medium? Or, in other words, which is the context of its emergence? This exploratory article attempts to answer these questions by focusing on the end of 2003 and during 2004, trying to systematize a series of explanatory factors to account for the beginning of (8300). Exploring its genesis has a transversal implication: regardless of how it interacts with the public sphere, the newspaper will have a political role, not a neutral one, positioning itself opposite other journalistic actors (La Mañana, for instance) and opposite the political actors of that time (the so-called sobischismo). By the end of the year 2004, this newspaper will try to slip through the crack to ensure its survival and continuity.(8300) es el código postal que hace referencia a un punto exacto del país para que el correo llegue a destino, y es también el nombre de un periódico de Neuquén cuyo origen se remonta a diciembre de 2003 cuando salió a la calle el primer ejemplar en papel. ¿En el seno de qué relaciones sociales y políticas nace (8300) como medio gráfico? o, en otros términos: ¿cuál es su contexto de surgimiento? El presente trabajo se ocupa de abordar estas inquietudes, entre fines del año 2003 y durante el año 2004, con un carácter exploratorio, intentando sistematizar una serie de factores explicativos que den cuenta de los inicios de (8300). Explorar la génesis tiene una implicancia transversal: se mueva como se mueva en el espacio público, el periódico lo hará como un actor político y no neutral, posicionándose de manera más o menos explícita frente al resto de los actores periodísticos (con el diario La Mañana, por ejemplo) y frente a los actores políticos del momento (el sobischismo). Hacia el final del año 2004, intentará encontrar algún intersticio que le garantice la supervivencia y la continuidad.Abstract(8300) is the post code that makes reference to an exact point of a country for the mail to get to its right destination, and it is also the name of a newspaper in Neuquén, whose origin dates back to December 2003 when its first printed edition came out. Within which social and political relationships was (8300) born as a graphic medium? Or, in other words, which is the context of its emergence? This exploratory article attempts to answer these questions by focusing on the end of 2003 and during 2004, trying to systematize a series of explanatory factors to account for the beginning of (8300). Exploring its genesis has a transversal implication: regardless of how it interacts with the public sphere, the newspaper will have a political role, not a neutral one, positioning itself opposite other journalistic actors (La Mañana, for instance) and opposite the political actors of that time (the so-called sobischismo). By the end of the year 2004, this newspaper will try to slip through the crack to ensure its survival and continuity
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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