1,722,728 research outputs found
Comparative studies of DL-8280 and pipemidic acid in complicated urinary tract infections by double-blind method
No full text複雑性尿路感染症に対するDL-8280の有効性, 安全性と有用性を客観的に評価するため, Pipemidic acid (PPA)を対照薬とし二重盲検法で比較検討した.DL-8280は1回200 mg, 1日3回, PPAは1回500 mg, 1日4回, を5日間連続経口投与した.総投与例数は311例で, 除外, 脱落を除く228例(DL-8280群115例, PPA群113例)に対し有効性を評価した.安全性の評価は306例(DL-8280群153例, PPA群153例), 有効性の評価は250例(DL-8280群124例, PPA群126例)につきおこなった.両群の背景因子には差はなかった.総合臨床効果は, DL-8280群で著効39.1%, 有効80.9%, PPA群それぞれ23.9, 57.5%と比較し有意に高かった.疾患病態群別には, 第2群(単独感染, 前立腺術後感染症)と第3群(単独感染, 上部尿路感染症)を除き, DL-8280群の総合臨床効果はPPA群に比し有意に優っていた.膿尿に対する効果は, 正常化率+改善率がDL-8280群で59.1%, PPA群で46.0%で, 前者が, 優る傾向をみた.細菌尿に対する効果では, DL-8280群の陰性化率は76.5%, PPA群は50.4%で, DL-8280群が有意に優っていた.細菌学的効果では, DL-8280群の分離菌の消失率89.0%に対し, PPA群は72.1%で, 有意差であった.グラム陰性桿菌, グラム陽性球菌についてもDL-8280群の消失率は有意に優っていた.主治医による臨床効果はDL-8280群が著効46.1%, 有効83.5%で, PPA群はそれぞれ26.5, 61, 1%で, 前者が有意に優っていた.有用性は, DL-8280群が"非常に満足", "満足"合わせて71.8%, PPA群が47.6%でDL-8280群が有意に優っていた.副作用はDL-8280群で11例, PPA群で12例に認め, 有意差はなく, 大部分は消化器症状で, 重篤なものはなかった.臨床検査値悪化もDL-8280群で10例, PPA群で9例にみ, 有意差はなかったThe clinical efficacy, safety and usefulness of DL-8280 for the treatment of complicated urinary tract infections were compared with those of pipemidic acid (PPA) by a double-blind method. DL-8280 and PPA were orally administered at a daily dose of 600 mg (t.i.d.) and 2.0 g (q.i.d.) for 5 days, respectively. Of the 311 patients who received DL-8280 or PPA, clinical efficacy, safety and usefulness were evaluated in 228 patients (DL-8280, 115; PPA, 113), 306 patients (DL-8280, 153; PPA, 153) and 250 patients (DL-8280, 124; PPA, 126), respectively. There was no significant difference in the background characteristics between the two groups. In the DL-8280 group the overall clinical efficacy was excellent in 39.1% and moderate in 41.7%, the effectiveness rate being 80.9%, whereas in the PPA group it was excellent in 23.9% and moderate in 33.6%, the effectiveness rate being 57.5%. The efficacy in the DL-8280 group was significantly higher than that in the PPA group (P less than 0.001). According to classification by the type of infection, the overall clinical efficacy of DL-8280 in groups except group 2 (monomicrobial infection, post prostatectomy) and group 3 (monomicrobial infection, upper urinary tract infection) was superior to that of PPA, the difference being significant. Pyuria was cleared or improved in 59.1% of the patients treated with DL-8280 and in 46.0% of the patients with PPA. The difference was not significant. Bacteriuria was eliminated in 76.5% in the DL-8280 group and in 50.4% in the PPA group. DL-8280 demonstrated a significantly higher response than PPA (P less than 0.001). Of the bacteria isolated from the DL-8280 group and PPA group 89.0% and 72.1%, respectively, were eradicated after the treatment, a significant difference being observed between the two groups (P less than 0.001). The clinical efficacy evaluated by the doctor in charge was excellent in 46.1% and good in 37.4% of the patients treated with DL-8280 and excellent in 26.5% and good in 34.5% of the patients treated with PPA, the intergroup difference in the efficacy being significant (P less than 0.001). The evaluation of usefulness of DL-8280 and PPA was "satisfactory" for 71.8% and 47.6%, respectively, the difference being significant (P less than 0.001). Side effects were observed in 11 patients (7.2%) in the DL-8280 group and in 12 patients (7.8%) in the PPA group, but none were serious.(ABSTRACT TRUNCATED AT 400 WORDS
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Poster: "Experimental Investigation of the Solids Circulation Rate and the Minimum Spouting Velocity in the Modified Spouted Bed"
No full textWhen designing a particle-fluid contactor with a spouted bed, the basic
parameters are the solids circulation rate and the minimum spouting velocity, i.e.
the velocity at which the spout forms along the entire bed1,2. When a draft tube is
placed along the spouted bed column, the minimum spouting velocity is the
velocity at which the particle bed reaches the top of the draft tube and forms a spout
at the exit of the tube. This paper presents the results of an experimental test on the
solids circulation rate and the minimum spouting velocity in a column with a draft
tube. The system consisted of a cylindrical column with a diameter of 100 mm, on
the conical bottom of which a smaller column with a diameter of 60 mm and a draft
tube with a diameter of 20 mm and 25 mm, and adjustable distance from the
bottom. Spherical glass particles were used in the experiments, and air introduced
at the bottom of the column and into the annular space was used as a fountaining
agent. The influence of the diameter and the distance of the draft tube from the
bottom on the solids circulation rate and the minimum spouting velocity was
determined and a comparison of the experimentally obtained values of the
minimum spouting velocity with the Matur-Gischler correlation was given.Poster presented at 27th Congress of the Society of Chemists and Technologists of Macedonia, 25th-28th September 2024, Ohrid, Macedonia
Abstract: [https://cer.ihtm.bg.ac.rs/handle/123456789/8280
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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