1,723,977 research outputs found
Glycine max Fermented by a Novel Probiotic, Bifidobacterium animalis subsp. lactis LDTM 8102, Increases Immuno-Modulatory Function
No full textMany probiotic species have been used as a fermentation starter for manufacturing functional food materials. We have isolated Bifidobacterium animalis subsp. lactis LDTM 8102 from the feces of infants as a novel strain for fermentation. While Glycine max has been known to display various bioactivities including anti-oxidant, anti-skin aging, and anti-cancer effects, the immune-modulatory effect of Glycine max has not been reported. In the current study, we have discovered that the extract of Glycine max fermented with B. animalis subsp. lactis LDTM 8102 (GFB 8102), could exert immuno-modulatory properties. GFB 8102 treatment increased the production of immune-stimulatory cytokines in RAW264.7 macrophages without any noticeable cytotoxicity. Analysis of the molecular mechanism revealed that GFB 8102 could upregulate MAPK2K and MAPK signaling pathways including ERK, p38, and JNK. GFB 8102 also increased the proliferation rate of splenocytes isolated from mice. In an animal study, administration of GFB 8102 partially recovered cyclophosphamide-mediated reduction in thymus and spleen weight. Moreover, splenocytes from the GFB 8102-treated group exhibited increased TNF-α, IL-6, and IL-1β production. Based on these findings, GFB 8102 could be a promising functional food material for enhancing immune function
Complete Genome Sequence and Phylogenetic Analysis of Nosocomial Pathogen Acinetobacter nosocomialis Strain NCTC 8102
No full textBackground Acinetobacter has emerged recently as one of the most challenging nosocomial pathogens because of its increased rate of antimicrobial resistance. The genetic complexity and genome diversity, as well as the lack of adequate knowledge on the pathogenic determinants of Acinetobacter strains often hinder with pathogenesis studies for the development of better therapeutics to tackle this nosocomial pathogen.
Objectives: In this study, we comparatively analyzed the whole genome sequence of a virulent Acinetobacternosocomialis strain NCTC 8102. Methods The genomic DNA of A. nosocomialis NCTC 8102 was isolated and sequenced using PacBio RS II platform. The sequenced genome was functionally annotated and gene prediction was carried out using the program, Glimmer 3. The phylogenetic analysis of the genome was performed using Mega 6 program and the comparative genome analysis was carried out by BLAST (Basic Local Alignment Search Tool). Results The complete genome analysis depicted that the genome consists of a circular chromosome with an average G+C content of 38.7%. The genome comprises 3700 protein-coding genes, 96 RNA genes (18 rRNA, 74 tRNA and 4 ncRNA genes), and 91 pseudogenes. In addition, 6 prophage regions comprising 2 intact, 1 incomplete and 3 questionable ones and 18 genomic islands were identifed in the genome, suggesting the possible occurrence of horizontal gene transfer in this strain. Comparative genome analysis of A. nosocomialis NCTC 8102 genome with the already sequenced A. nosocomialis strain SSA3 showed an average nucleotide identity of 99.0%. In addition, the number of prophages and genomic islands were higher in the A. nosocomialis NCTC 8102 genome compared to that of the strain SSA3. 14 of the genomic islands were unique to A. nosocomialis NCTC 8102 compared to strain SSA3 and they harbored genes which are involved in virulence, multidrug resistance, bioflm formation and bacterial pathogenesis. Conclusion We sequenced the whole genome of A. nosocomialis strain NCTC 8102 followed by comparatively genome analysis. The study provides valuable information on the genetic features of A. nosocomialis strain and the data from this study would assist in further studies for the development of control measures for this nosocomial pathogen
[Pennsylvania R.R. for Akron & Barberton Belt R. R., Engine Drawing Card, Sketch No. 8102]
No full textThis engine drawing card was created for Pennsylvania Railroad Company, Class 6-38-D. Section N-6-D. Sketch 8102. Copy Spec. 29D177
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
فعالية استخدام وسائل الأغنية في تعليم القواعد في الصف العاشر بالمدسسة الثانوية بحر العلوم بربولنجو للعام الدسسي 8102-8102
No full textملخص
البحث العلم بالموضوع "فعالية استخدام وسائل الأغنية في تعليم القواعد في الفصل العاشر بالمدسسة الثانوية
بحر العلوم بروبولنجو العام الدساسي 8102/8102"، الذي كتبتها سلفيا حسنة، رقم القيد.
17616153141، المشرف الدكتور صاحب الماجستير.
الكلمات الإشاسية: وسائل الأغنيات و تعليم القواعد.
خلفية البحث: يوجد معلم اللغة العربية الصعوبة في اختيار الوسيلة الصحيحة ليعلم القواعد في تعليم
اللغة العربية، لذلك، يكون مطلوبا على الوسيلة الصحيحة ليعلم القواعد لأن يسهل معلم اللغة العربية لوصول
أهداف التعليم، وأحدها هو استخدام وسائل الأغنيات.باستخدام هذه الوسيلة، يمكن أن يعرف أن الطلاب أكثر
هماسا لتعليم القواعد اللغة العربية. الغرض من تعليم القواعد في تعلم اللغة العربية هو تسهيل القراءة الطلاب و
الكتابة اللغة العربية.
مسائل البحث: ) 1(هل توجد فعالية إستخدام وسائل الأغنية في تعليم القواعد في الصف العاشر
بالمدرسة الثانوية بحرالعلوم بربولينجو للعام الدراسي 6118-6112؟ )6( كم قيمة فعالية استخدام الوسائل
الأغنية في التعليم القواعد في الصف العاشر بالمدرسة الثانوية بحرالعلوم بربولينجو للعام الدراسي 6118-6112؟
الغرض من هذه البحث هو ) 1( معرفة ما إذا كان استخدام وسائل الأغنية فعالاً في تعلم القواعد في
الفصل العاشر بالمدرسة الثانوية بحر العلوم بروبولنجو العام الدراسي 6118/6112 ، )6( لمعرفة الى أ ّي بع ٍد
فعالية وسائل الأغنية في تعلم القواعد في الفصل العاشر بالمدرسة الثانوية بحر العلوم بروبولنجو العام الدراسي
.6112/6118
منهج البحث : تستخدم هذه البحث منه ًجا كميًا ، مع نوع البحث قبل التجريبي) Pre
Experimental( و باستخدام تصميم البحث )Group Design one posttest-pretest(.
طريقة جمع البيانات المستخدمة هي اختبار.إن تقنية تحليل البيانات المستخدمة هي تحليل البيانات الإحصائية)
Test-T Sampel Paired(، و استخدام الرمز Size Effect s‘Cohenلقياس قيمة فعلية هذه
الطريقة.
نتائج البحث : استناداً إلى نتائج تحليل البيانات البحث تبين أن: ) 1( وسائل الأغنية فعالا لتعليم
القواعد بقيمة أهمية ).sig(= 111،1< 15،1
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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