1,724,324 research outputs found
[Pickands Mather & Company, Engine Drawing Card, Sketch No. 8042]
No full textThis engine drawing card was created for Pickands Mather & Company, Class 8-44 E. Section N-8 E. Sketch 8042. Copy Spec. 29-D-4
Linked collectors and determiners for: LUSC herbarium - Universidade do Estado de Santa Catarina - Herbário Virtual Reflora.
No full textNatural history specimen data linked to collectors and determiners held within, "LUSC herbarium - Universidade do Estado de Santa Catarina - Herbário Virtual Reflora". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/9b511323-32c7-4d5e-8042-5356a08aa32b">https://bionomia.net/dataset/9b511323-32c7-4d5e-8042-5356a08aa32b</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/9b511323-32c7-4d5e-8042-5356a08aa32b">https://gbif.org/dataset/9b511323-32c7-4d5e-8042-5356a08aa32b</a>. Formatted as a Frictionless Data package
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Abrogation of stemness in osteosarcoma by the mithramycin analog EC-8042 is mediated by its ability to inhibit NOTCH-1 signaling
No full textOsteosarcomas are frequently associated to a poor prognosis and a modest response to current treatments. EC-
8042 is a well-tolerated mithramycin analog that has demonstrated an efficient ability to eliminate tumor
cells, including cancer stem cell subpopulations (CSC), in sarcomas. In transcriptomic and protein expression
analyses, we identified NOTCH1 signaling as one of the main pro-stemness pathways repressed by EC-8042 in
osteosarcomas. Overexpression of NOTCH-1 resulted in a reduced anti-tumor effect of EC-8042 in CSC-enriched
3D tumorspheres cultures. On the other hand, the depletion of the NOTCH-1 downstream target HES-1 was able
to enhance the action of EC-8042 on CSCs. Moreover, HES1 depleted cells failed to recover after treatment
withdrawal and showed reduced tumor growth potential in vivo. In contrast, mice xenografted with NOTCH1-
overexpressing cells responded worse than parental cells to EC-8042. Finally, we found that active NOTCH1
levels in sarcoma patients was associated to advanced disease and lower survival. Overall, these data highlight
the relevant role that NOTCH1 signaling plays in mediating stemness in osteosarcoma. Moreover, we demonstrate
that EC-8042 is powerful inhibitor of NOTCH signaling and that the anti-CSC activity of this mithramycin
analog highly rely on its ability to repress this pathwayAgencia Estatal de Investigacion (AEI) [MICINN/Fondo Europeo de Desarrollo Regional (FEDER) PID2019106666RB-I00Spanish Government CB16/12/00390Plan de Ciencia Tecnologia e Innovacion del Principado de Asturias/FEDER IDI/2021/000027
BP-17108
BP-20046
BP-2108
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Antitumoral activity of the mithralog EC-8042 in triple negative breast cancer linked to cell cycle arrest in G2
No full textThis is an open-access article distributed under the terms of the Creative Commons Attribution License.Triple negative breast cancer (TNBC) is an aggressive form of breast cancer. Despite response to chemotherapy, relapses are frequent and resistance to available treatments is often observed in the metastatic setting. Therefore, identification of new therapeutic strategies is required. Here we have investigated the effect of the mithramycin analog EC-8042 (demycarosil-3D-β-D-digitoxosyl mithramycin SK) on TNBC. The drug caused a dose-dependent inhibition of proliferation of a set of TNBC cell lines in vitro, and decreased tumor growth in mice xenografted with TNBC cells. Mechanistically, EC-8042 caused an arrest in the G2 phase of the cell cycle, coincident with an increase in pCDK1 and Wee1 levels in cells treated with the drug. In addition, prolonged treatment with the drug also causes apoptosis, mainly through caspaseindependent routes. Importantly, EC-8042 synergized with drugs commonly used in the therapy of TNBC in vitro, and potentiated the antitumoral effect of docetaxel in vivo. Together, these data suggest that the mithralog EC-8042 exerts an antitumoral action on TNBC cells and reinforces the action of standard of care drugs used in the therapy of this disease. These characteristics, together with a better toxicology profile of EC-8042 with respect to mithramycin, open the possibility of its clinical evaluation.The Cancer Research Institute receives support from the European Community through the regional development funding program (FEDER), and from the Fundación Ramón Areces. Ministry of Economy and Competitiveness of Spain (BFU2009-07728 and BFU2012-39151), the Instituto de Salud Carlos III through the Spanish Cancer Centers Network Program (RD12/0036/0003) and the Scientific Foundation of the Spanish Association Against Cancer (AECC) and the CRIS Foundation to AP. JCM is a recipient of a Miguel Servet fellowship program (CP12/03073). The work carried out by A.O receives support by Instituto de Salud Carlos III; Fondo de Investigación Sanitaria (FIS), PI13/01444.Peer Reviewe
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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