1,723,784 research outputs found
Postcard: 8033. Sea Wall, Galveston, Texas
No full textPostcard: 8033. Sea Wall, Galveston, Texas; not postmarked.https://mavmatrix.uta.edu/specialcollections_texaspostcards/1000/thumbnail.jp
Effect of METi (MK-8033) treatment on MET phosphorylation in <i>GNAQ</i> mutant and wild-type uveal melanoma cells.
No full text<p>(A) The upper panel demonstrates the effect of MK-8033 at 0, 1 and 2.5 µM on MET phosphorylation in WT uveal melanoma cells (MEL290), and the lower panel demonstrates the effect of MK-8033 on MET phosphorylation in <i>GNAQ</i> mutant cells (MEL202). Total MET protein expression is shown for each cell line under each condition. (B) Effect of METi (MK-8033) and/or MEKi (AZD6244) treatment on Erk1/2 phosphorylation in <i>GNAQ</i> mutant and wild-type uveal melanoma cells. The upper panel demonstrates the effect of MK-8033 and/or AZD6244 on Erk1/2 phosphorylation in WT uveal melanoma cells (MEL285), and the lower panel demonstrates the effect of MK-8033 and/or AZD6244 on Erk1/2 phosphorylation in <i>GNAQ</i> mutant uveal melanoma cells (MEL202).</p
Linked collectors and determiners for: Colección de referencia del Herbario CUVC de la Universidad del Valle.
No full textNatural history specimen data linked to collectors and determiners held within, "Colección de referencia del Herbario CUVC de la Universidad del Valle". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/e92a7b4a-55ed-4b0b-8033-9bf38643d019">https://bionomia.net/dataset/e92a7b4a-55ed-4b0b-8033-9bf38643d019</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/e92a7b4a-55ed-4b0b-8033-9bf38643d019">https://gbif.org/dataset/e92a7b4a-55ed-4b0b-8033-9bf38643d019</a>. Formatted as a Frictionless Data package
Abstract 759: Discovery of MK-8033, a highly specific c-Met/Ron dual inhibitor for the treatment of cancer
No full textAbstract
MK-8033 is a highly specific c-Met/Ron dual inhibitor currently under investigation in Phase I clinical trials for the treatment of cancer. The discovery of MK-8033 is described including the first public disclosure of its structure. Additionally, an X-ray co-crystal structure of MK-8033 with the activated form of c-Met will be discussed to address why, contrary to established dogma, an inhibitor of an activated kinase conformation can lead to high specificity. The in vitro and in vivo properties of MK-8033 as well as aspects of the structure-activity relationships in this class will also be discussed.
Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 759.</jats:p
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
An unusual iconography of Osiris: The bronze statuette Petrie Museum UC 8033
No full textAmong the wide collection of the bronze figurines preserved at the Petrie Museum, UC 8033 represents Osiris with an iconography rarely attested: the representation on the back of a falcon with a sun disc and with wings wrapping the body of the figure. Unfortunately, the figurine is unprovenanced and no other information are preserved in the museum. This paper presents also five other Osiris figurines (1- BM EA 24718; 2- Brooklyn Museum, inv. no. 39.93; 3- MMA 56.16.2; 4- CG 38270; 5- Statuette from a private collection – unknown location –), which show close parallels in iconography, design, and composition with UC 8033. Furthermore, the peculiar iconography of the falcon on the back is not exclusively used for Osiris, but it is in use also for other statuettes, mainly representing goddesses, such as Neith and Isis, and high social rank women, such as the famous statue of Karomama (Louvre N 500). The chronological range of UC 8033 seems to be circumscribed to the time between the Third Intermediate Period and the early Twenty-six Dynasty
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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