1,724,089 research outputs found
Antiarrhythmic, Electrophysiological and Haemodynamic Effects of Prolonged Oral Dosing with Org 7797 in the Anaesthetized Rat
No full textAbstract
The antiarrhythmic, electrophysiological and haemodynamic effects of chronic oral administration of Org 7797 ((16α,17β)-17-methylamino-oestra-1,3,5(10)-triene-3,16-diol-(Z)-2-butonedioate) were studied in rats. During dosing (10 mg kg−1 twice a day for 10 days) no effects on the electrocardiogram, monitored in conscious animals, were observed despite modest reductions (15–18%) in the maximum rate of depolarization of papillary muscle excised 1 or 6 h after completion of the dosing regime. Following anaesthesia, Org 7797 reduced the severity of arrhythmias induced by coronary artery occlusion and prevented the accompanying decrease in the ventricular fibrillation threshold (VFT) at 1 h after completion of dosing. By 6 h the effect on VFT had waned but protection against ischaemia-induced arrhythmias was retained despite a substantial decrease in Org 7797 plasma levels. Drug treatment did not modify arterial blood pressure, heart rate or stroke volume. We conclude that Org 7797 given chronically via the oral route exerts antiarrhythmic actions which may, at least in part, be due to sodium-channel block. In addition, our results suggest the presence of an active metabolite. The protective effects of Org 7797 were seen in the absence of electrocardiographic or haemodynamic changes suggesting that multiple oral doses of Org 7797 do not compromise normal cardiac function.</jats:p
The spectral type of CHS 7797 - an intriguing very low mass periodic variable in the Orion Nebula Cluster
Get PDFAims: We present the spectroscopic characterization of the unusual high-amplitude very low mass pre-main-sequence periodic variable CHS 7797. Methods: This study is based on optical medium-resolution (R = 2200) spectroscopy in the 6450 − 8600 Å range, carried out with GMOS-GEMINI -S in March 2011. Observations of CHS 7797 have been carried out at two distinct phases of the 17.8 d period, namely at maximum (I ≈ 17.4 mag) and four days before maximum (I ≈ 18.5 mag). Four different spectral indices were used for the spectral classification at these two phases, all of them well-suited for spectral classification of young and obscured late M dwarfs. In addition, the gravity-sensitive Na I (8183/8195 Å) and K I (7665/7699 Å) doublet lines were used to confirm the young age of CHS 7797. Results: From the spectrum obtained at maximum light we derived a spectral type (SpT) of M 6.05 ± 0.25, while for the spectrum taken four days before maximum the derived SpT is M 5.75 ± 0.25. The derived SpTs confirm that CHS 7797 has a mass in the stellar-substellar boundary mass range. In addition, the small differences in the derived SpTs at the two observed phases may provide indirect hints that CHS 7797 is a binary system of similar mass components surrounded by a tilted circumbinary disk, a system similar to KH 15D.Fil: Rodriguez Ledesma, María V.. Max-Planck-Institut fur Astronomie; Alemania. Georg-August-Universität; AlemaniaFil: Mundt, Reinhard. Max-Planck-Institut fur Astronomie; AlemaniaFil: Pintado, Olga Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Correlación Geológica. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Departamento de Geología. Cátedra Geología Estructural. Instituto Superior de Correlación Geológica; ArgentinaFil: Boudreault, Steve. Instituto de Astrof´ısica de Canarias; España. Universidad de la Laguna; EspañaFil: Hessman, Frederic. Georg-August-Universität; AlemaniaFil: Herbst, William. Wesleyan University; Estados Unido
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
[Chicago, Burlington, & Quincy R.R. Co., Engine Drawing Card, Sketch No. 7797]
No full textThis engine drawing card was created for Chicago, Burlington & Quincy Railroad Company, Class 16-58 1/4 F. Section J-16 1/4 F. Sketch 7797. Copy Spec. [field left blank]
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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