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Ro 90-7501 inhibits PP5 through a novel, TPR-dependent mechanism
No full textProtein phosphatase 5 (PP5) is a serine/threonine phosphatase that belongs to the PPP family phosphatases. PP5 and the other phosphatases of the PPP family share significantly similar catalytic domain structure. Due to this structural similarity, natural competitive inhibitors such as okadaic acid and cantharidin exhibit broad specificity over the PPP family phosphatases. In this study, we report the identification of three PP5 inhibitors, Ro 90-7501, aurothioglucose, and N-oleoyldopamine, along with a novel inhibitory mechanism of Ro 90-7501. Unlike other inhibitors binding to the phosphatase domain, Ro 90-7501 inhibited PP5 in a TPR-dependent manner. This TPR-dependent PP5 inhibition shown by Ro 90-7501 is a unique and novel inhibitory mechanism, which might be a useful tool for studies of PP5 on both regulatory mechanism and drug discovery. (C) 2016 Elsevier Inc. All rights reserved.OAIID:RECH_ACHV_DSTSH_NO:T201725797RECH_ACHV_FG:RR00200001ADJUST_YN:EMP_ID:A076390CITE_RATE:2.559DEPT_NM:화학생물공학부EMAIL:[email protected]_YN:YN
Networking research in front ending and intelligent terminals : H6000 software specifications
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Previous issue date: 1977"Removed ""author."" from creator fields.
Metadata cleaned/updated by [email protected]""""CCTC-WAD document no. 7501.""""""Prepared for the Command and Control Technical Center, WWMCCS ADP Directorate, Defense Communications Agency, Washington, D. C."""Bibliography: leaf 26
RO 90–7501 selectively enhances the activation of IFN-β promoter but not NFκB reporter by poly I:C.
No full text<p>(A) Structure of RO 90–7501. (B) 293TLR3/IFNβLuc and 293TLR3/NFκBLuc cells were mock treated or treated with 10 µM of RO 90–7501, 2 µg/ml of poly I:C, alone or in combination for 16 h. Luciferase activities were normalized to mock-treated controls and expressed as fold of induction (mean +/− standard deviation, n = 8). P values were calculated using the two-tailed student t test. (C) 293TLR3/IFNβLuc and 293TLR3/NFκBLuc cells were mock treated or treated with 2 µg/ml of poly I:C in the absence or presence of the indicated concentrations of RO 90–7501 for 16 h. The effects of RO 90–7501 on the IFN-β promoter and NFκB reporter activation were normalized to mock-treated controls and expressed as fold of induction of luciferase activity (mean +/− standard derivation, n = 3). P values were calculated using the two-tailed student t test, with * indicates P<0.05 compared to poly I:C treated alone. (D) 293TLR3/IFNβLuc cells were mock treated or treated with indicated concentrations of RO 90–7501 for 16 h. Cell viability was determined by a MTT assay and the results were plotted as the dose-dependent absorbance values at 570 nm.</p
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Testing the accuracy of distance measurement on reflective foil with Topcon GPT-7501
No full textBakalářská práce popisuje testování přesnosti dálkoměrů šesti přístrojů Topcon GPT-7501. K testování byla použita základna s interferometrem a pilířová základna s nucenými centracemi, obě umístěné na Fakultě stavební ČVUT v Praze. Na základně s interferometrem byly detailně určovány relativní chyby, které byly převedeny na absolutní chyby dálkoměrů pomocí měření na pilířové základně. Pro všechny přístroje byl zobrazen podrobný chybový průběh dálkoměru při měření na odraznou folii.This bachelor's thesis deals with the process of testing the accuracy of six Topcon GPT-7501's distance meters. The testing was performed on distancemeter calibration bench with interferometer and laboratory pillar baseline with forced centration, both located at CTU, Faculty of Civil Engineering in Prague. In the thesis relative errors were determined at calibration bench with interferometer and afterwards converted to absolute errors at pillar baseline. For all instruments were determined detailed course of distance meter error for measuring at the reflective foil
California Poll: 7501 -- February 15 - March 3, 1975
No full textThe Field Poll, established in 1945 as The California Poll by Mervin Field, has operated continuously as an independent, non-partisan, media-sponsored public opinion news service. Each year the Field Polls cover a wide range of political and social topics examining California public opinion. Continuing measures are made of voter support for leading political figures vying for major state and federal offices, job ratings of important political figures and reactions to significant political events. Voter awareness, understanding and predispositions of major campaign issues and salient statewide ballot propositions are also tracked over time. For poll 7501 N=1011
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