1,725,038 research outputs found
The periods of the intermediate polar RX J0153.3+7446
Get PDFWe present the first optical photometry of the counterpart to the candidate intermediate polar RX J0153.3+7446. This reveals an optical pulse period of 2333±5 s. Reanalysis of the previously published ROSAT X-ray data reveals that the true X-ray pulse period is probably 1974±30 s, rather than the 1414 s previously reported. Given that the previously noted orbital period of the system is 3.94 h, we are able to identify the X-ray pulse period with the white dwarf spin period and the optical pulse period with the rotation period of the white dwarf in the binary reference frame, as commonly seen in other intermediate polars. We thus confirm that RX J0153.3+7446 is indeed a typical intermediate polar
[Manufacturers Ry. Co., St. Louis and O'Fallon Ry. Co., Engine Drawing Card, Sketch No. 7446]
No full textThis engine drawing card was created for Manufacturer's Railway Company, Class 10-36 1/4 D. Section J-10 1/4 D. Sketch 7446. Copy Spec. C-8385
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Discovery of BI 7446: A Potent Cyclic Dinucleotide STING Agonist with Broad-Spectrum Variant Activity for the Treatment of Cancer
No full textActivating the stimulator
of interferon genes (STING)
pathway with
STING agonists is an attractive immune oncology concept to treat patients
with tumors that are refractory to single-agent anti-PD-1 therapy.
For best clinical translatability and broad application to cancer
patients, STING agonists with potent cellular activation of all STING
variants are desired. Novel cyclic dinucleotide (CDN)-based selective
STING agonists were designed and synthesized comprising noncanonical
nucleobase, ribose, and phosphorothioate moieties. This strategy led
to the discovery of 2′,3′-CDN 13 (BI 7446),
which features unprecedented potency and activates all five STING
variants in cellular assays. ADME profiling revealed that CDN 13 has attractive drug-like properties for development as
an intratumoral agent. Injection of low doses of CDN 13 into tumors in mice induced long-lasting, tumor-specific immune-mediated
tumor rejection. Based on its compelling preclinical profile, BI 7446
has been advanced to clinical trials (monotherapy and in combination
with anti-PD-1 antibody)
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