1,746,098 research outputs found
miR-668 inhibitor attenuates mitochondrial membrane potential and protects against neuronal apoptosis in cerebral ischemic stroke
No full textCerebral stroke is a major cause of brain injury due to the production of hypoxic conditions, and new therapeutic interventions are required for its management. Here, we evaluated the protective effect of miR-668 inhibitor against ischemia/reperfusion (I/R)-induced stroke. Cerebral stroke was induced by cerebral artery occlusion in rats, followed by treatment with miR-668 inhibitor for 10 minutes before reperfusion. The neuroprotective effect of miR-668 inhibitor was determined by estimating the neurological deficit score, cerebral infarct area and blood-brain barrier (BBB) permeability. In addition, the levels of inflammatory cytokines, and the expression of NLRP3, zonula occludens-1 (ZO-1), dynamin-related protein 1 (Drp1) and occludin proteins, were estimated by ELISA and Western blotting, respectively. TUNEL assay and immunohistochemical analyses were performed to examine the effects of miR-668 inhibitor against I/R-induced stroke rats. The miR-668 inhibitor treatment group showed reductions in the infarct area, BBB permeability and neurological score compared to the stroke group. The levels of cytokines and reactive oxygen species were reduced in the miR-668 inhibitor treatment group compared to the stroke group. These observations suggested that inhibition of miR-668 reduces neuronal apoptosis by ameliorating the expression of caspase 3, Bax and Bcl-2 protein in I/R stroke rats. The expression of NLRP3, ZO-1 and occludin proteins was attenuated in the brain tissue of the miR-668 inhibitor treatment group compared to the stroke group. Moreover, the phosphorylation of Drp1 protein was reduced in the miR-668 inhibitor group compared to the stroke group. In conclusion, the results of the present study indicated that inhibition of miR-668 prevented neuronal apoptosis in cerebral I/R-induced stroke by modulating mitochondrial function and regulating NLRP3 signalling
El Tlacuache Núm. 668 (2015). 668 Año 13 (2015) abril. El Tlacuache
No full textDel ejote a la caña: estrategias de campesinos
morelenses, en la región Centro-Oriente por Adriana Saldaña Ramírez, El legendario “Güero de Ticumán”. Una monta trágica por la educación por Isidro Aragó
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Verlustliste Nr. 668. (Nr. 668. /1918)
No full textVERLUSTLISTE NR. 668.
Verlustliste (-)
Verlustliste Nr. 668. (Nr. 668. /1918) ([1])
Belehrung. (2)
Offiziere. (3)
A, B, C, D, E, F, G, H, J, K, L (3)
M (3)
N, O, P, R, S, T, U, W, Z (4)
Einjährig-Freiwillige. (4)
B, C, E, F, G (4)
H (4)
K, L, M, N, O, P, R, S, T, V, W (5)
Mannschaft. (5)
A (5)
B (6)
C (10)
D (12)
E (13)
F (14)
G (16)
H (18)
I (22)
J (22)
K (24)
L (37)
M (43)
N (46)
O (48)
P (48)
Q (51)
R (51)
S (53)
T (59)
U (60)
V (61)
W (62)
Z (63)
Berichtigungen zu den Verlustlisten: (64)
Nr. 10. Nr. 85. Nr. 121. Nr. 164. Nr. 262. Nr. 318. Nr. 332. Nr. 376. Nr. 398. Nr. 416. Nr. 427. Nr. 450. Nr. 452. Nr. 458. Nr. 461. (64)
Nr. 517. Nr. 553. Nr. 561. Nr. 569. Nr. 578. Nr. 581. Nr. 588. Nr. 594. Nr. 609-611. Nr. 614. Nr. 615. Nr. 619. Nr. 621-625. Nr. 627. Nr. 632. Nr. 634. Nr. 636. Nr. 646. Nr. 648. Nr. 649. Nr. 651. Nr. 653-658. (65)
Nr. 658. Nr. 659. (66)
Ergänzungen und Berichtigungen zu den Verlustlisten: (66)
Nr. 21. Nr. 127. Nr. 297. Nr. 653. Nr. 656. (66)
Berichtigungen der Internierungsorte der aus Serbien nach Italien und Frankreich gebrachten Kriegsgefangenen. (66
Sufism and Ethics [668]
No full textSufism and Ethics.
This manuscript is now IO Islamic 1529 in the India Office collections.
[metadata: Otto Loth, A Catalogue of the Arabic Manuscripts in the Library of the India Office, (volume 1), no. 668 here with further notations and hyperlinks].
668.
1529. Size 93/4 in. by 53/4 in.; foll. 21. Thirteen lines in a page.
رسالۀ خضر
An account of al Khiḍr, the patron saint of the Ṣûfîs; the author is not named.
Begins:الحمدلله الذى خص من اصطفاه للحضرة القدسية الخ.
This treatise is a mere compilation. It is divided into five chapter, as follows: I.(fol.2) فى ذكر نسبه الخ ;
II.(fol.5v.) فى اثبات حيوته الخ ; III. (fol. 11v.) فى الاحاديث التى رواها عن نبينا الخ (twenty traditions) ; IV. (fol. 14) فيما رُوى عنه و لم يرفعه الى النبى الخ (also twenty) ; V.(fol.19) فى ذكر اسباب بقائه الخ .
According to a statement on fol. 4 this treatise was written in A.H. 860; therefore, it is probably that of IMÂM AL-KÂMILÎYAH (Kamâl al-dîn Muḥammad Shâfi’î, d. A.H. 874), mentioned in Ḥ. Kh. iii. 393.
Well written in Nasta’liḳ, of the eleventh century. Marginal notes. Slightly injured by insects
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Characteristics of the study population by Intervention in family physician program (2005: N = 668, 2013: N = 668).
No full textCharacteristics of the study population by Intervention in family physician program (2005: N = 668, 2013: N = 668).</p
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