1,750,819 research outputs found
MicroRNA-665-3p exacerbates nonalcoholic fatty liver disease in mice
No full textOxidative stress and chronic inflammation are major culprits of nonalcoholic fatty liver disease (NAFLD). MicroRNA-665-3p (miR-665-3p) is implicated in regulating inflammation and oxidative stress; however, its role and molecular basis in NAFLD remain elusive. Herein, we measured a significant upregulation of miR-665-3p level in the liver and primary hepatocytes upon high fat diet (HFD) or 0.5 mmol/L palmitic acid plus 1.0 mmol/L oleic acid stimulation, and the elevated miR-665-3p expression aggravated oxidative stress, inflammation and NAFLD progression in mice. In contrast, miR-665-3p inhibition by the miR-665-3p antagomir significantly prevented HFD-induced oxidative stress, inflammation and hepatic dysfunction in vivo. Manipulation of miR-665-3p in primary hepatocytes also caused similar phenotypic alterations in vitro. Mechanistically, we demonstrated that miR-665-3p directly bound to the 3ʹ-untranslated region of fibronectin type III domain-containing 5 (FNDC5) to downregulate its expression and inactivated the downstream AMP-activated protein kinase alpha (AMPKα) pathway, thereby facilitating oxidative stress, inflammation and NAFLD progression. Our findings identify miR-665-3p as an endogenous positive regulator of NAFLD via inactivating FNDC5/AMPKα pathway, and inhibiting miR-665-3p may provide novel therapeutic strategies to treat NAFLD.</p
Resolución UNRN N° 665/2009. Autoriza traslado
No full textFil: Universidad Nacional de Río Negro (U). Universidad Nacional de Río Negro. Río Negro, ArgentinaResolución UNRN N° 665/2009. Autoriza trasladofals
La concimazione di tappeti erbosi con forme di azoto a diversa velocità di rilascio dell'elemento. Nota I. Applicazione primaverile.
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Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Verlustliste Nr. 665. (Nr. 665. /1918)
No full textVERLUSTLISTE NR. 665.
Verlustliste (-)
Verlustliste Nr. 665. (Nr. 665. /1918) ([1])
Belehrung. (2)
Offiziere. (3)
A-G (3)
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T-Z (5)
Einjährig-Freiwillige. (5)
B-M (5)
N-Z (6)
Mannschaft. (6)
A (6)
B (7)
C (11)
D (13)
E (14)
F (14)
G (16)
H (17)
I (19)
J (19)
K (20)
L (23)
M (25)
N (32)
O (34)
P (35)
Q (40)
R (40)
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U (54)
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A-G (63)
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Nr. 34. Nr. 36. Nr. 201. Nr. 204. Nr. 435. Nr. 529. Nr. 634. (65
665. Kosaku
No full textIwao Seiichi, Iyanaga Teizō, Ishii Susumu, Yoshida Shōichirō, Fujimura Jun'ichirō, Fujimura Michio, Yoshikawa Itsuji, Akiyama Terukazu, Iyanaga Shōkichi, Matsubara Hideichi. 665. Kosaku. In: Dictionnaire historique du Japon, volume 13, 1987. Lettre K (3) pp. 98-99
Spottswood, Henry Mercer, III,b. 1940 (MSS 665)
No full textFinding aid only for Manuscripts Collection 665. Correspondence with poet and author Jim Wayne Miller, Bowling Green, Kentucky. Chiefly letters to Spottswood which contain numerous attachments about Miller’s writing and speaking engagements. Also includes a small amount of correspondence from Miller’s wife, Mary Ellen Miller, and an unpublished book of poems by WKU students
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
665. Suiko
No full textIwao Seiichi, Iyanaga Teizō, Ishii Susumu, Yoshida Shōichirō, Fujimura Jun'ichirō, Fujimura Michio, Yoshikawa Itsuji, Akiyama Terukazu, Iyanaga Shōkichi, Matsubara Hideichi. 665. Suiko. In: Dictionnaire historique du Japon, volume 18, 1992. Lettre S (2) pp. 153-154
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