1,725,046 research outputs found
Billing, A G, 6325
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/371791Surname: BILLING
Given Name(s) or Initials: A G
Military Service Number or Last Known Location: 6325
Missing, Wounded and Prisoner of War Enquiry Card Index Number: 19954182711
Item: [2016.0049.04118] "Billing, A G, 6325
Doubly Protected anti-CTLA-4-6325: A Novel Antibody-Drug Conjugate
No full textAntibody-drug conjugates are a subset of cancer immunotherapy that allows for reduction of harmful side effects by targeting cytotoxic drugs to tumor cells through selective binding. This study focused on anti-CTLA-4-6325, an antibody-drug conjugate that targets tumor stromal cells in sarcomas and carcinomas. Anti-CTLA-4 and 6325 work together to enhance the innate anti-tumor immune response by stimulating and activating inactive T-cells. However, conjugation of 6325 can render the conjugate ineffective by binding to the CTLA-4 and FcɣRIV binding sites, which are essential to the proper function of anti-CTLA-4. In this study, a version of anti-CTLA-4-6325 was created that was blocked from binding to both the CTLA-4 and FcɣRIV binding sites to study the effect of 6325 conjugation on FcɣRIV binding. Protection at the FcɣRIV binding site did not significantly increase the FcɣRIV binding affinity of the conjugate. This was validated through molecular modeling, showing very few available conjugation sites at or near the binding site. Further studies would be needed to further clarify the effects of 6325 conjugation on FcɣRIV binding and anti-CTLA-4 function
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
B, V and I photometry of the intermediate metallicity bulge globular clusters NGC 6325 and NGC 6355
Get PDFColour-Magnitude Diagrams are presented for the globular clusters NGC 6325 and NGC 6355. These clusters are embedded in crowded bulge fields. Both clusters are concentrated and have blue Horizontal Branches, and NGC 6325 shows a blue tail. We derive a reddening E(B−V) 0:95 and a distance from the Sun d 6:9 kpc for NGC 6325, and E(B−V) 0:78 and d 8:8 kpc for NGC 6355. They are both at 1 kpc from the Galactic center, above the plane. The metallicity has been estimated based on red giant branch morphology, being consistent with an intermediate metallicity of [Fe=H] −1:3 for both clusters, at the lower end of the metallicity distribution of bulge field stars. They add to the list of blue Horizontal Branch clusters with intermediate metallicities within the bulge volume
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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