2,173,338 research outputs found
MOESM1 of miR-624-5p promoted tumorigenesis and metastasis by suppressing hippo signaling through targeting PTPRB in osteosarcoma cells
No full textAdditional file 1: Fig. S1. miR-624-5p had the potential ability to promote OS cell proliferation. A–B. The Cell Counting Kit-8 (CCK-8) assay and colony formation analysis reveal that downregulating miR-624-5p significantly reduced cell proliferation after 5 days (A, n = 4; B, n = 4). C–D. Upregulation of miR-624-5p significantly increased proliferation of the MG63 and U2OS cells (C, n = 4; D, n = 4)
MicroRNA-624-mediated ARRDC3/YAP/HIF1α axis enhances esophageal squamous cell carcinoma cell resistance to cisplatin and paclitaxel
No full textDevelopment of chemoresistance remains a major challenge in treating patients suffering from esophageal squamous cell carcinoma (ESCC), despite treatment advances. MicroRNAs (miRNAs) have been shown to play critical roles in the regulation of ESCC cell chemoresistance. Here, we aimed to investigate the role of miR-624 in ESCC and its molecular mechanism in mediating the resistance of ESCC cells to two common chemotherapeutic drugs, cisplatin (CIS) and paclitaxel (PT). Expression patterns of miR-624, arrestin domain-containing 3 (ARRDC3), Yes-associated protein (YAP), and hypoxia-inducible factor-1α (HIF1α) in ESCC tissues and cell lines were identified using RT-qPCR and Western blot analysis. The binding affinities with the miR-624/ARRDC3/YAP/HIF1α axis were characterized. The chemotherapy-sensitive cell line KYSE150 and chemotherapy-resistant cell line KYSE410 were transfected with an overexpression plasmid or shRNA to study the effect of miR-624/ARRDC3/YAP/HIF1α axis on ESCC cell resistance to CIS and PT. Their in vivo effects on resistance to PT were assessed in tumor-bearing nude mice. High expression of miR-624, YAP and HIF1α, and low expression of ARRDC3 were observed in ESCC tissues and cell lines. miR-624 presented with higher expression in KYSE410 than in KYSE150 cells. miR-624 downregulated ARRDC3 to increase YAP and HIF1α expression so as to enhance ESCC cell resistance to CIS and PT in vitro and in vivo. Taken together, these data indicate an important role for miR-624 in promoting the chemoresistance of ESCC cells, highlighting a potential strategy to overcome drug resistance in ESCC treatment. miR-624 targets ARRDC3 to inhibit its expression, and consequently upregulates YAP expression by inhibiting degradation of YAP. By this mechanism, HIF1α expression is upregulated and the HIF1α signaling pathway is activated. ESCC cell chemotherapy resistance is eventually increased.</p
Resolución UNRN N° 624/2009. Designar a cargo de las funciones propias del Rector Organizador al Vicerrector de la Sede Atlántica
No full textFil: Universidad Nacional de Río Negro (U). Universidad Nacional de Río Negro. Río Negro, ArgentinaResolución UNRN N° 624/2009. Designar a cargo de las funciones propias del Rector Organizador al Vicerrector de la Sede Atlánticafals
Verlustliste Nr. 624. (Nr. 624. /1917)
No full textVERLUSTLISTE NR. 624.
Verlustliste (-)
Verlustliste Nr. 624. (Nr. 624. /1917) ([1])
Belehrung. (2)
Offiziere. (3)
A, B, C, D, E, F, G (3)
H (3)
I, J, K, L, M, N, O, P, R (4)
S (4)
T, V, W, Z (5)
Einjährig-Freiwillige. (5)
A, B, C, D, F, G, H, J, K, L, M, O, P (5)
R, S, T, V (6)
Mannschaft. (6)
A (6)
B (7)
C (10)
D (13)
E (16)
F (17)
G (20)
H (21)
I (23)
J (23)
K (24)
L (32)
M (33)
N (37)
O (38)
P (39)
R (43)
S (47)
T (52)
U (53)
V (53)
W (54)
Z (55)
Berichtigungen zu den Verlustlisten: (56)
Nr. 511. Nr. 610. Nr. 611. (56
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
El Tlacuache Núm. 624 (2014). 624 Año 13 (2014) junio. El Tlacuache
No full textLa Empatía: Fundamentos teóricos, medición, estimulación, y su percepción social por Marte E. Roel Lesur. - El cóndor del sur y el águila de norte en resistencia por Georgina Galván Medina
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