1,754,158 research outputs found
(Table 1) Isotopic analysis of Globigerinoides ruber and CaCO3 of sediments from DSDP Hole 96-619
No full textA detailed oxygen-isotope record and planktonic foraminiferal biostratigraphy are used to construct a chronostratigraphic framework for Site 619, Pigmy Basin, on the Louisiana continental slope. Within this framework, sediments accumulated in Pigmy Basin at a fairly constant rate over the last 105,000 yr. The oxygen-isotope record shows evidence for periods of freshwater run-off at times other than glacial terminations. Increased carbonate contents are also associated with these event
DataSheet_1_Super-Enhancer-Associated Long Non-Coding RNA LINC01485 Promotes Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells by Regulating MiR-619-5p/RUNX2 Axis.docx
No full textObjectiveTo investigate the mechanisms of super-enhancer-associated LINC01485/miR-619-5p/RUNX2 signaling axis involvement in osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs).MethodsOsteogenic differentiation of hBMSCs was induced in vitro. The expression levels of LINC01485 and miR-619-5p during osteogenesis were measured using quantitative real-time polymerase chain reaction (qRT-PCR). Osteogenic differentiation was examined by qRT-PCR, western blot, alkaline phosphatase (ALP) staining, ALP activity measurement, and Alizarin Red S (ARS) staining assays. Thereafter, the effects of LINC01485 and miR-619-5p on osteogenic differentiation of hBMSCs were evaluated by performing loss- and gain-of-function experiments. Subsequently, a fluorescence in situ hybridization (FISH) assay was employed to determine the cellular localization of LINC01485. Bioinformatics analysis, RNA antisense purification (RAP) assay, and dual-luciferase reporter assays were conducted to analyze the interactions of LINC01485, miR-619-5p, and RUNX2. Rescue experiments were performed to further delineate the role of the competitive endogenous RNA (ceRNA) signaling axis consisting of LINC01485/miR-619-5p/RUNX2 in osteogenic differentiation of hBMSCs.ResultsThe expression of LINC01485 was up-regulated during osteogenic differentiation of hBMSCs. The overexpression of LINC01485 promoted osteogenic differentiation of hBMSCs by up-regulating the expression of osteogenesis-related genes [e.g., runt-related transcription factor 2 (RUNX2), osterix (OSX), collagen type 1 alpha 1 (COL1A1), osteocalcin (OCN), and osteopontin (OPN)], and increasing the activity of ALP. ALP staining and ARS staining were also found to be increased upon overexpression of LINC01485. The opposing results were obtained upon LINC01485 interference in hBMSCs. miR-619-5p was found to inhibit osteogenic differentiation. FISH assay displayed that LINC01485 was mainly localized in the cytoplasm. RAP assay results showed that LINC01485 bound to miR-619-5p, and dual-luciferase reporter assay verified that LINC01485 bound to miR-619-5p, while miR-619-5p and RUNX2 bound to each other. Rescue experiments illustrated that LINC01485 could promote osteogenesis by increasing RUNX2 expression by sponging miR-619-5p.ConclusionLINC01485 could influence RUNX2 expression by acting as a ceRNA of miR-619-5p, thereby promoting osteogenic differentiation of hBMSCs. The LINC01485/miR-619-5p/RUNX2 axis might comprise a novel target in the bone tissue engineering field.</p
Verlustliste Nr. 619. (Nr. 619. /1917)
No full textVERLUSTLISTE NR. 619.
Verlustliste (-)
Verlustliste Nr. 619. (Nr. 619. /1917) ([1])
Belehrung. (2)
Offiziere. (3)
B, C, D, E, F, G, H, K, L, M, N, O, P, R, S, T, V, W (3)
Z (4)
Einjährig-Freiwillige. (4)
Mannschaft. (4)
A (4)
B (5)
C (9)
D (10)
E (13)
F (13)
G (15)
H (16)
I (18)
J (18)
K (20)
L (25)
M (26)
N (30)
O (31)
P (32)
R (33)
S (34)
T (47)
U (53)
V (53)
W (54)
Z (55)
Ergänzung zur Verlustliste: (60)
Nr. 20. (60)
Berichtigungen zu den Verlustlisten: (60)
Nr. 103. Nr. 125. (60)
Nr. 432. Nr. 522. Nr. 536. Nr. 565. (61)
Ergänzung und Berichtigung zur Verlustliste: (61)
Nr. 213. (61)
Berichtigungen bereits veröffentlichter, jedoch nicht legal nachweisbarer Todesfälle. (61)
Nr. 45. Nr. 342. (61
[Ferrocarril Mexicano, Locomotive No. 619]
No full textImage of Ferrocarril Mexicano locomotive no. 619.Verso: [stamped] 516. F.C. Mexicano 619
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
El Tlacuache Núm. 619 (2014). 619 Año 13 (2014) abril. El Tlacuache
No full textLos sahumadores a través del tiempo en Tlayacapan por Nancy Karina Mendoza Becerrra, Sara Paulina Sánchez Guzmán, Jorge Linares Ramírez, Enrique Méndez Tores y Raúl Francisco González Quezada
(Table 1) Conditions of consolidation and excess pore-water pressures for sediments at DSDP Hole 96-619
No full textGeotechnical examination of 180 m of core recovered in Pigmy Basin at Site 619 in the Gulf of Mexico indicates that excess pore-water pressures are present in the lower section of the hole. Shear strength-vertical effective stress relationships and consolidation testing (oedometer) indicate that the sediments are normally consolidated in the upper 30 m and underconsolidated below. The presence of gas within the pore waters greatly affected the measurements of shear strength, water content, and porosity in the interval between 80 and 160 m sub-bottom
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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