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(Table 4) Benthic foraminiferal genera in DSDP Core 95-612-16 and 95-612-17
No full text(Table 4) Benthic foraminiferal genera in DSDP Core 95-612-16 and 95-612-1
(Table 3) Benthic foraminiferal genera in DSDP Core 95-612-21-5 and 95-612-21-6
No full text(Table 3) Benthic foraminiferal genera in DSDP Core 95-612-21-5 and 95-612-21-
Benthic foraminiferal genera in DSDP Hole 95-612
No full textOn the basis of lithologic, foraminiferal, seismostratigraphic, and downhole logging characteristics, we identified seven distinctive erosional unconformities at the contacts of the principal depositional sequences at Site 612 on the New Jersey Continental Slope (water depth 1404 m). These unconformities are present at the Campanian/Maestrichtian, lower Eocene/middle Eocene, middle Eocene/upper Eocene, upper Eocene/lower Oligocene, lower Oligocene/upper Miocene, Tortonian/Messinian, and upper Pliocene/upper Pleistocene contacts. The presence of coarse sand or redeposited intraclasts above six of the unconformities suggests downslope transport from the adjacent shelf by means of sediment gravity flows, which contributed in part to the erosion. Changes in the benthic foraminiferal assemblages across all but the Campanian/Maestrichtian contact indicate that significant changes in the seafloor environment, such as temperature and dissolved oxygen content, took place during the hiatuses.
Comparison with modern analogous assemblages and application of a paleoslope model where possible, indicate that deposition took place in bathyal depths throughout the Late Cretaceous and Cenozoic at Site 612. An analysis of two-dimensional geometry and seismic fades changes of depositional sequences along U.S.G.S. multichannel seismic Line 25 suggests that Site 612 was an outer continental shelf location from the Campanian until the middle Eocene, when the shelf edge retreated 130 km landward, and Site 612 became a continental slope site. Following this, a prograding prism of terrigenous debris moved the shelf edge to near its present position by the end of the Miocene.
Each unconformity identified can be traced widely on seismic reflection profiles and most have been identified from wells and outcrops on the coastal plain and other offshore basins of the U.S. Atlantic margin. Furthermore, their stratigraphic positions and equivalence to similar unconformities on the Goban Spur, in West Africa, New Zealand, Australia, and the Western Interior of the U.S. suggest that most contacts are correlative with the global unconformities and sea-level falls of the Vail depositional model
Synopsis of CTH 612 16th day [of the festival] : to the temple of Zababa - CTH 612
No full textNotes on the tablet concordances listed in the CTH 612 which are related to the festival taking place in the temple of Zababa. Emmanuel Laroche translated this text as "16e jour : au temple de ZABABA,” and classified in the category of texts of festivals and cults dedicated to AN.TAH.SUMsar (Catalogue des textes Hittites, No. 612).Paper (4 sheets
Synopsis of CTH 612 16th day [of the festival] : to the temple of Zababa - CTH 612
No full textNotes on the tablet concordances listed in the CTH 612 which are related to the festival taking place in the temple of Zababa. Emmanuel Laroche translated this text as "16e jour : au temple de ZABABA,” and classified in the category of texts of festivals and cults dedicated to AN.TAH.SUMsar (Catalogue des textes Hittites, No. 612).Paper (4 sheets
Cretaceous foraminifers from DSDP Hole 95-612
No full textSite 612, located some 100 km southeast of Atlantic City in the northwest Atlantic Ocean, was cored to a total depth of 675.3 m below seafloor. The final 114.96 m recovered an Upper Cretaceous succession that can be assigned to the late Campanian and early Maestrichtian. The dark mudstones of Campanian age contain an impoverished fauna of planktonic foraminifers, while the paler, nannofossil chalks of Maestrichtian age contain a typically diverse planktonic fauna. The environment represented by the Campanian fauna indicates the presence of slightly anoxic water in the vicinity of the New Jersey Slope at that time
(Table 1) Ostracoda community from DSDP Hole 95-612
No full textSamples 95-612-8X-3,80-84 to 95-612-13X-3,80-84 barren
(Figure 2) Range and distribution chart of dinoflagellate cysts recovered from Campanian to Maestrichtian sediments at DSDP Hole 95-612
No full textFifty-nine samples from the basal 110 m of DSDP Hole 612 (United States Atlantic Margin) were analyzed for palynomorph content. In total, 84 species and subspecies of dinoflagellate cysts were recorded which, on comparison with published data and shipboard analyses, indicate a Campanian to Maestrichtian age for this part of the succession. The Campanian/Maestrichtian contact is taken to occur in the upper part of Core 612-69
Mössbauer study at DSDP Hole 95-612
No full text57Fe Mössbauer spectra of 15 oceanic sediment samples collected from Site 612 (Deep Sea Drilling Project Leg 95) were recorded. These spectra showed that most of the iron in the sediments was present as high-spin, paramagnetic Fe2+ and Fe3+. The ferrous iron was mainly distributed in terrigenous clays and biogenic carbonates. The variation of the Mössbauer parameters for Fe2+ with sub-bottom depth suggests that the main Fe2+-bearing component changed with geologic time. The amount of iron in each iron-bearing phase as estimated from the corresponding peak areas in the spectra also changed with depth. These variations in the Mössbauer parameters and peak areas are correlated with lithologic changes in the sediment column
miR-612 Enhances RSL3-Induced Ferroptosis of Hepatocellular Carcinoma Cells via Mevalonate Pathway
No full textKailin Xing,1,* Xinyu Bian,2,* Dongmin Shi,3,* Shuangshuang Dong,1 Hongxin Zhou,1 Shuxiu Xiao,4 Jinjin Bai,4 Weizhong Wu1,4 1Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Shanghai, 200032, People’s Republic of China; 2Department of Radiation Oncology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210000, People’s Republic of China; 3Department of Medical Oncology, Shanghai Changzheng Hospital, Shanghai, 200072, People’s Republic of China; 4Clinical Center for Biotherapy, Zhongshan Hospital, Fudan University, Shanghai, 200032, People’s Republic of China*These authors contributed equally to this workCorrespondence: Weizhong Wu, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, 200032, People’s Republic of China, Tel +86-21-60268628, Fax +86-21-64037181, Email [email protected]: MicroRNA-612 (miR-612) has been proven to suppress the formation of invadopodia and inhibit hepatocellular carcinoma (HCC) metastasis by hydroxyacyl-CoA dehydrogenase alpha subunit (HADHA)-mediated lipid reprogramming. However, its biological roles in HCC cell ferroptosis remain unclear.Methods and Results: In this study, we found that HCC cells with high metastatic potential were more resistant to ferroptosis, indicating that ferroptosis is related to HCC metastasis. The levels of lipid reactive oxygen species (ROS) were found to be much lower in HCC cells with high metastatic potential by flow cytometry (FCM). We used HCC cells with miR-612 overexpression/knockout and HADHA overexpression/knockdown to test cell viability after stimulation with RSL3. HCC cells overexpressing miR-612 were more sensitive to ferroptosis, and miR-612 could increase lipid ROS levels. Furthermore, colony formation assays and Transwell assays showed that miR-612 could inhibit the proliferation and metastasis of HCC cells by promoting ferroptosis. We next confirmed that miR-612 influenced HCC cell ferroptosis by regulating HADHA. HADHA could upregulate the expression of key enzymes in the mevalonate (MVA) pathway. HADHA overexpression upregulated the expression of CoQ10 and decreased polyunsaturated fatty acid (PUFA) levels and lipid peroxide abundance. miR-612 also suppressed HCC cell proliferation and metastasis by enhancing RSL3- and lovastatin-induced ferroptosis in vivo.Conclusion: Overall, miR-612 promotes ferroptosis in HCC cells and affects HCC proliferation and metastasis by downregulating CoQ10 and increasing cellular PUFA levels and lipid peroxides via the HADHA-mediated MVA pathway.Keywords: HCC, Ferroptosis, miR-612, HADHA, MVA pathwa
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