1,723,006 research outputs found
Southern Pacific diesel engine #6027, unknown location
No full textHandwritten on back: "Southern Pacific Unit #6027 Cab 102"
Block Card 6027 Jackman Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Dwelling | 6027 Jackman Road (Toledo, Ohio) | Side gabled | Hopewell Acres (Toledo, Ohio) | Greenwood Area (Toledo, Ohio) | West Toledo Area (Toledo, Ohio) | Folk House Styl
Block Card 6027 Pickard Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Dwelling | 6027 Pickard Drive (Toledo, Ohio) | Side gabled | Hopewell Acres (Toledo, Ohio) | Greenwood Area (Toledo, Ohio) | West Toledo Area (Toledo, Ohio) | Folk House Styl
NU-6027 Inhibits Growth of Mycobacterium tuberculosis by Targeting Protein Kinase D and Protein Kinase G
No full textTuberculosis (TB) is a global health concern, and this situation has further worsened due to the emergence of drug-resistant strains and the failure of BCG vaccine to impart protection. There is an imperative need to develop highly sensitive, specific diagnostic tools, novel therapeutics, and vaccines for the eradication of TB. In the present study, a chemical screen of a pharmacologically active compound library was performed to identify antimycobacterial compounds. The phenotypic screen identified a few novel small-molecule inhibitors, including NU-6027, a known CDK-2 inhibitor. We demonstrate that NU-6027 inhibits Mycobacterium bovis BCG growth in vitro and also displayed cross-reactivity with Mycobacterium tuberculosis protein kinase D (PknD) and protein kinase G (PknG). Comparative structural and sequence analysis along with docking simulation suggest that the unique binding site stereochemistry of PknG and PknD accommodates NU-6027 more favorably than other M. tuberculosis Ser/Thr protein kinases. Further, we also show that NU-6027 treatment induces the expression of proapoptotic genes in macrophages. Finally, we demonstrate that NU-6027 inhibits M. tuberculosis growth in both macrophage and mouse tissues. Taken together, these results indicate that NU-6027 can be optimized further for the development of antimycobacterial agents
[Newburg [sic] and South Shore, Engine Drawing Card, Sketch 6027]
No full textThis engine drawing card was created for Newburgh & South Shore Railway, Class 8-40-D. Section N-8-D. Sketch 6027. Copy Spec. C-1789
Scaling and similarity in rough channel flows
No full textMade available in DSpace on 2021-11-04T16:29:45Z (GMT). No. of bitstreams: 2
TAM988-UILU-ENG-2001-6027.pdf: 1926054 bytes, checksum: 689afb6a4b90bdf3bcb0c450fb0fde33 (MD5)
license.txt: 4802 bytes, checksum: 58353f9dd6876860dd5221f3d7872a95 (MD5)
Previous issue date: 2001-1
Local displacements and load transfer in shape memory alloy composites
No full textMade available in DSpace on 2021-11-04T16:28:51Z (GMT). No. of bitstreams: 2
TAM805-UILU-ENG-1995-6027.pdf: 5285368 bytes, checksum: 5e3d4d5404920b8837585dfdc8e2bae9 (MD5)
license.txt: 4802 bytes, checksum: 58353f9dd6876860dd5221f3d7872a95 (MD5)
Previous issue date: 1995-0
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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