1,753,932 research outputs found
Trykk 602
No full text602 med tittel: Direktiver for innkjøps- og forrådsvirksomheten i distriktene ; den lokale forsyningsvirksomhe
Gayle Gooslin discusses her career as the UAW Local 602 secretary and bookkeeper
No full textGift of UAW/GM.Gayle describes her work at MSU before coming to work for Local 602 as an OPIEU represented secretary. Gayle describes her duties, activities in the Hall, and comments on the generosity and charitable giving of the workers. She also recalls a joke played on the local union president
El Tlacuache Núm. 602 (2013). 602 Año 13 (2013) diciembre. El Tlacuache
No full text50 años de Arqueozoología en México. Apuntes para una conmemoración por Eduardo Corona Martínez, Semblanza de Ticul Álvarez por Fernando Sánchez Martínez, Algunas aportaciones del INAH a la paleontología del Pleistoceno en México por Felisa J. Aguilar
Resolución UNRN N° 602/2009. Convoca para párticipar de la muestra Contratapas de la Revista Barcelona
No full textFil: Universidad Nacional de Río Negro (U). Universidad Nacional de Río Negro. Río Negro, ArgentinaResolución UNRN N° 602/2009. Convoca para párticipar de la muestra Contratapas de la Revista Barcelonafals
MIA-602
No full textAcute myeloid leukemia (AML) is a malignant neoplastic disease arising from myeloid cell lines. AML is characterized by the proliferation of immature, nonfunctional cells in the bone marrow. Excessive proliferation of immature blasts in the bone marrow impairs all other cell lines, resulting in anemia, clotting disorders, and increased susceptibility to infections. Standard of care for treatment involves cytarabine and anthracycline-based regimens. A major concern with such regimens is the acquisition of drug-induced toxicities and subsequent development of drug-resistance. This study aimed to investigate the role of MIA-602, a growth hormone-releasing hormone receptor (GHRH-R) antagonist in the treatment of AML cell line K-562. GHRH-R antagonist MIA-602 was synthesized by solid phase method and purified by reversed-phase high performance liquid chromatography (HPLC). The peptide was dissolved in dimethyl sulfoxide (DMSO) and diluted with incubation media. Doxorubicin was purchased from Sigma-Aldrich. K562 cells were maintained as a cell suspension in the commercially defined RPMI 1640 medium, supplemented with 10% heat-inactivated fetal bovine serum (FBS) and gentamicin. K562 cells were seeded onto six well microplates containing 10% FBS at a density of 5.0×104 cells/ml. Doxorubicin treatment concentrations were 0.005, 0.01, and 0.05 µg/µl. Combination therapy concentrations 0.005, 0.01, and 0.05 µg/µl of doxorubicin and 5 µmol/L of MIA-602. Proliferation was observed and recorded at 24 hours and 48 hours. Incubation of cells with doxorubicin showed a decrease in proliferation in a dose-dependent manner. Co-incubation of K562 cells with MIA-602 and doxorubicin showed a significantly greater reduction in proliferation (p<0.05). Co-administration of doxorubicin and MIA-602 was shown to have a synergistic effect, when compared to doxorubicin alone at all concentrations at 24 and 48 hours. The 0.05 µg DOX + MIA was shown to be the most effective dose in reducing proliferation. Co-administration of doxorubicin and the GHRH-R antagonist MIA-602 was shown to have a synergistic effect in reducing proliferation of the K-562 AML cell line. Use of MIA-602 in combination with chemotherapy-based regimens may help prevent the acquisition of resistance in AML. Further investigation into molecular mechanisms behind the synergistic effect of MIA-602 could provide insight into improving clinical outcomes AML treatment
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Resolución UNRN Nº 602/2010. Modificar Resolución UNRN Nº 652/2009
No full textFil: Universidad Nacional de Río Negro (U). Universidad Nacional de Río Negro. Río Negro, ArgentinaResolución UNRN Nº 602/2010. Modificar Resolución UNRN Nº 652/2009 en lo relativo a la definición de los alcances y a los parámetros para su gestión en la modalidad semipresencial de acuerdo con lo previsto en la Resolución ME 1717/04fals
CKD-602 Chong Kun Dang
No full textChong Kun Dang is developing the camptothecin analog CKD-602 for the potential treatment of cancer. By August 2000, phase II trials of CKD-602 were underway
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