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Advance American Designer Pattern 6004 - Front
No full textFront side of an Advance American Designer Pattern (6004) envelope.https://digitalcommons.pittstate.edu/nellydonpatterns/1006/thumbnail.jp
Advance American Designer Pattern 6004 - Back
No full textBack side of an Advance American Designer Pattern (6004) envelopehttps://digitalcommons.pittstate.edu/nellydonpatterns/1008/thumbnail.jp
C.N.R. steam engine #6004 taking water, unknown location
No full textHandwritten on back: "CNR #6004"
Block Card 6004 Atwell Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 6004 Atwell Road (Toledo, Ohio) | Dwelling | Edgehill Subdivision (Toledo, Ohio) | Trilby Area (Toledo, Ohio)
Tumor-targeted chemotherapy with the nanopolymer-based drug NC-6004 for oral squamous cell carcinoma
Get PDFCisplatin (CDDP) has been a key drug for chemotherapy in patients with head and neck squamous cell carcinoma. Nephrotoxicity is one of its adverse reactions that are dose limiting. To increase its antitumor effects and reduce such toxicity problems, polymeric micelles carrying CDDP (NC-6004) have been developed. The present study was designed to evaluate the efficacy and safety of NC-6004 for oral squamous cell carcinoma. In vitro antitumor activity was assayed in four oral squamous cell carcinoma cell lines. To investigate the antitumor and nephrotoxic effects of NC-6004, nude mice bearing OSC-19 were administered NC-6004 or CDDP. The in vitro growth-inhibitory effect of NC-6004 was significantly less than that of CDDP. However, both NC-6004 and CDDP showed equivalent antitumor effects in vivo. Mice with CDDP developed renal cell apoptosis; however, those injected with NC-6004 were almost free of renal cell injury. Moreover, in an orthotopic tongue cancer model using OSC-19, NC-6004 reduced the rate of sentinel lymph node metastasis to lower than that with CDDP. In conclusion, considering the potential advantages in terms of noticeable antitumor activity, lymphatic drug delivery and reduced nephrotoxicity, NC-6004 represents a significant structural improvement in the development of a platinum complex. © 2012 Japanese Cancer Association.医薬保健研究域医学系journal articl
Tumor-targeted chemotherapy with the nanopolymer-based drug NC-6004 for oral squamous cell carcinoma
No full textCisplatin (CDDP) has been a key drug for chemotherapy in patients with head and neck squamous cell carcinoma. Nephrotoxicity is one of its adverse reactions that are dose limiting. To increase its antitumor effects and reduce such toxicity problems, polymeric micelles carrying CDDP (NC-6004) have been developed. The present study was designed to evaluate the efficacy and safety of NC-6004 for oral squamous cell carcinoma. In vitro antitumor activity was assayed in four oral squamous cell carcinoma cell lines. To investigate the antitumor and nephrotoxic effects of NC-6004, nude mice bearing OSC-19 were administered NC-6004 or CDDP. The in vitro growth-inhibitory effect of NC-6004 was significantly less than that of CDDP. However, both NC-6004 and CDDP showed equivalent antitumor effects in vivo. Mice with CDDP developed renal cell apoptosis; however, those injected with NC-6004 were almost free of renal cell injury. Moreover, in an orthotopic tongue cancer model using OSC-19, NC-6004 reduced the rate of sentinel lymph node metastasis to lower than that with CDDP. In conclusion, considering the potential advantages in terms of noticeable antitumor activity, lymphatic drug delivery and reduced nephrotoxicity, NC-6004 represents a significant structural improvement in the development of a platinum complex. © 2012 Japanese Cancer Association.医薬保健研究域医学
Block Card 6004 Livingston Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Dwelling | 6004 Livingstone Drive (Toledo, Ohio) | Ranch houses | Hopewell Acres (Toledo, Ohio) | Greenwood Area (Toledo, Ohio) | West Toledo Area (Toledo, Ohio
Advance American Designer Pattern 6004 - Instruction Sheet 1
No full textSide one of an Advance American Designer Pattern (6004)https://digitalcommons.pittstate.edu/nellydonpatterns/1009/thumbnail.jp
Elastic wave propagation in rods and bars
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TAM434-UILU-ENG-79-6004.pdf: 5886057 bytes, checksum: 683f5e597afac37f7904381b20524f14 (MD5)
license.txt: 4802 bytes, checksum: 58353f9dd6876860dd5221f3d7872a95 (MD5)
Previous issue date: 1979-1
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