1,724,085 research outputs found
Equipment parameters of Instron 5967 dual-column tabletop testing machine.
No full textEquipment parameters of Instron 5967 dual-column tabletop testing machine.</p
Effects of the Ca2+ antagonist RO 40-5967 on endothelium-dependent responses of isolated arteries
No full textExperiments were designed to determine whether the Ca2+ channel inhibitor RO 40-5967 [(1S,2S)-2-[2-[[3-(2- benzimidazolyl)propyl]methylamine]ethyl]-6-fluoro-1,2,3,4-tetr ahydro-1- isopropyl-2-naphthyl methoxyacetate dihydrochloride] causes endothelium- dependent relaxations or inhibits endothelium-dependent contractions of isolated blood vessels. Rings of dog femoral, carotid, and basilar arteries and of rat aorta, with and without endothelium, were suspended in conventional organ chambers for measurement of isometric force. During contractions evoked by phenylephrine (full α1-adrenergic agonist), St 587 (partial α1-adrenergic agonist) and endothelin-1 (ET), RO 40-5967 caused concentration-dependent relaxations of rings of dog femoral arteries; the relaxations to RO 40-5967 were greater in rings with endothelium than in those without endothelium. Nitro-L-arginine (NLA) and methylene blue (MB) inhibited the endothelium-dependent component of the response to RO 40-5967 during contractions to phenylephrine (PE) St 587 and ET. The endothelium- dependent relaxations evoked by RO 40-5967 during contractions to PE were not affected by diltiazem in the femoral artery, suggesting that this effect of the compound may not be related to its calcium channel inhibitor properties. Under bioassay conditions, RO 40-5967 stimulated release of relaxing factors from the endothelium of canine carotid arteries; the response of the detector tissues was inhibited by MB. In strips of canine femoral artery with endothelium, in which membrane potential of vascular smooth muscle cells (VSMC) was recorded with glass microelectrodes, RO 40-5967 did not cause endothelium-dependent hyperpolarizations. RO 40-5967 caused concentration- dependent inhibition of endothelium-dependent contractions of canine basilar arteries to acetylcholine (ACh), arachidonic acid (AA), and the Ca2+ ionophore A23187. Likewise, RO 40-5967 decreased the contractions evoked by ACh in rings with endothelium of the aorta of spontaneously hypertensive rats. These experiments suggest that in isolated arteries RO 40-5967 causes release of endothelium-derived relaxing factor (EDRF; nitric oxide, NO) and inhibits endothelium-dependent contractions. These effects of the compound may help explain its vasodilator properties in vivo.link_to_subscribed_fulltex
Linked collectors and determiners for: Naturalis Biodiversity Center (NL) - Collembola.
No full textNatural history specimen data linked to collectors and determiners held within, "Naturalis Biodiversity Center (NL) - Collembola". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/4f8de55f-5967-46c4-b689-31de17090ed4">https://bionomia.net/dataset/4f8de55f-5967-46c4-b689-31de17090ed4</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/4f8de55f-5967-46c4-b689-31de17090ed4">https://gbif.org/dataset/4f8de55f-5967-46c4-b689-31de17090ed4</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: Naturalis Biodiversity Center (NL) - Collembola.
No full textNatural history specimen data linked to collectors and determiners held within, "Naturalis Biodiversity Center (NL) - Collembola". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/4f8de55f-5967-46c4-b689-31de17090ed4">https://bionomia.net/dataset/4f8de55f-5967-46c4-b689-31de17090ed4</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/4f8de55f-5967-46c4-b689-31de17090ed4">https://gbif.org/dataset/4f8de55f-5967-46c4-b689-31de17090ed4</a>. Formatted as a Frictionless Data package
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
[Portuguese East Africa State Rys., Engine Drawing Card, Sketch No. 5967]
No full textThis engine drawing card was created for Portuguese East Africa State Railways, Class 14-36 1/4 F. Section N-14 1/4 F. Sketch 5967. Copy Spec. C-1451
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Chronic treatment with the Ca2+ channel inhibitor RO 40-5967 potentiates endothelium-dependent relaxations in the aorta of the hypertensive salt sensitive Dahl rat
No full textExperiments were designed to determine whether or not chronic treatment with the Ca2+ channel antagonist RO 40-5967 affects endothelium-dependent relaxations in the aorta of hypertensive, salt-sensitive Dahl rats. Salt- resistant and salt-sensitive Dahl rats were fed a diet containing 8% NaCl (for 8 weeks); in each group, half of the animals were given RO 40-5967 chronically (0.4 mg/l; in the drinking water). RO 40-5967 lowered arterial blood pressure in the salt-sensitive, hypertensive, but not in the salt- resistant, normotensive rats. Rings, with and without endothelium, of thoracic aortas were suspended for isometric tension recording in conventional organ chambers. The chronic treatment with RO 40-5967 potentiated endothelium-dependent relaxations to acetylcholine, adenosine- diphosphate and thrombin in preparations from salt-sensitive, but not in those of salt-resistant Dahl rats. The treatment also augmented, in aortas from salt-sensitive animals, the relaxations of rings without endothelium to the donor of nitric oxide, SIN-1. These experiments demonstrate that chronic administration of RO 40-5967 potentiates endothelium-dependent relaxations in arteries from animals with salt-induced hypertension. This potentiation can be explained in part by an augmented sensitivity of the vascular smooth muscle to endothelium-derived nitric oxide.link_to_subscribed_fulltex
- …
