1,723,177 research outputs found
Block Card 5756 Adelaide Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Bungalow Style | 5756 Adelaide Drive (Toledo, Ohio) | Dwelling | Silver Creek Hills Addition (Toledo, Ohio) | Trilby Area (Toledo, Ohio)
BI-5756 Reduces Graft-Versus-Host Disease Through CB1-Mediated Treg Upregulation
Get PDFCannabinoid receptor 1 (CB1) has been implicated in multiple inflammatory diseases by regulating pro-inflammatory mediators or altering immune cell polarization. However, the expression and direct functional role of CB1 in T cells remain largely unexplored. Here, we demonstrate that primary murine T cells express CB1 and that its novel agonist, BI-5756, directly increases the frequencies of regulatory T cells (Tregs) in primary murine pan T cells after activation. In addition, BI-5756 exhibits an in vivo protective effect against graft-versus-host disease (GvHD), an allogeneic T cell-mediated inflammatory complication after allogeneic hematopoietic cell transplantation (allo-HCT), resulting in an improved overall survival with enhanced platelet recovery and reconstitution of bone marrow-derived B and T cells. BI-5756 also directly suppresses tumor cell growth and upregulates MHC I, MHC II, and CD80 on tumor cells, which may subsequently enhance T cell-mediated anti-tumor responses in mixed lymphocyte reaction with A20 cells. The ability of BI-5756 to increase Tregs was significantly abrogated by rimonabant, a potent and selective CB1 antagonist, suggesting that the immunomodulatory effect of BI-5756 is mediated via CB1. In summary, BI-5756, a potent CB1 agonist, increases Tregs while preserving anti-tumor responses in vitro and effectively reduces GvHD in vivo
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
A New Class Of Haemophilus Ducreyi? Molecular Characterization Of Samoa Strains Sb 5755, Sb 5756,Sb 5757, And Be 3145
Get PDFHaemophilus ducreyi is a Gram negative, strict human pathogen that causes the genital ulcer disease chancroid. Chancroid is a sexually transmitted infection that may aid in transmission of the Human Immunodeficiency Virus. Haemophilus ducreyi can be categorized into two strain classes, class I (CI) and class II (CII), based on variations in DNA sequence and protein expression of several virulence determinants including Ducreyi Serum Resistance protein A (DsrA) and the Necessary for Collagen Adhesion protein (NcaA). Recently, the first description of non-sexually associated chancroid transmission in children with chronic lower limb ulcerations was reported. Bacteria isolated from the children were sequenced and determined to possess a 16 S rDNA sequence that was 100% identical to Haemophilus ducreyi CII strain 33921. The purpose of this study was to categorize four strains of Haemophilus ducreyi isolated from children in Samoa as CI or CII based on DsrA and NcaA nucleotide and amino acid sequence. Based on the presence of a 16S rDNA that was 100% identical to CII strain 33921, we hypothesized that these strains were CII. To examine DsrA and NcaA, strains SB 5755, SB 5756, SB 5757, and BE 3135 were subjected to Polymerase Chain Reaction and DNA sequencing. SB 5755, SB 5756, and BE 3145 was 90%, 96% and 97% identical to dsrA in the CI parent strain 35000 HP, respectively. Moreover, alignment of DsrA the xii predicted protein sequences demonstrated that SB 5755, SB 5756, and BE3145 were 71%, 87%, and 92% identical to 35000 HP. However, comparison with HMC112 dsrAII revealed a high degree of variability between the N-terminal regions. SB 5755 had 7% identites and 17% similarities, SB 5756 had 7% identites and 21% similarites, and BE 3145 had 5% identies and 17% similarites to dsrAII These data indicate that SB 5755, SB 5756, and BE 3145 are not CII, but are indeed CI strains
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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