1,723,845 research outputs found
Block Card 5743 Adelaide Drive
This image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Gable front houses | Folk House Style | Dwelling | Silver Creek Hills and Dales Addition (Toledo, Ohio) | Trilby Area (Toledo, Ohio)) | 5743 Adelaide Drive (Toledo, Ohio) | 5743 Adelaide Drive (Toledo, Ohio
Block Card 5743 Fryer Avenue
This image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Dwelling | Inverness Suburban Acres (Toledo, Ohio) | Reynolds Corners Area (Toledo, Ohio) | 5743 Fryer Avenue (Toledo, Ohio) | Folk House Styl
Block Card 5743 Jackman Road
This image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Mohr Hardware | 20th Century Commercial Style | Greenwood Area (Toledo, Ohio) | West Toledo (Toledo, Ohio) | 5743 Jackman Road (Toledo, Ohio
Abstract 5743: Liposome platform enables X-ray induced photodynamic therapy treatment against human triple negative breast cancer cells
Abstract
In this study, we employed X-ray induced photodynamic therapy (X-PDT) for the treatment on triple negative breast cancer (TNBC) cells. To do this, we rationally developed a liposome delivery system co-loaded with protoporphyrin IX (PPIX) and perfluorooctyl bromide (PFOB). Low-dose X-ray at 2Gy was employed to activate PPIX for reactive oxygen species (ROS) generation, and the co-loading of PFOB provided additional oxygen to augment ROS production. The highly toxic ROS triggered TNBC cell death. In vitro X-PDT effects including intracellular ROS generation, cytotoxicity, cell viability and apoptosis/necrosis assay in TNBC cells were studied. Our results indicate that the nanocarriers effectively induced X-PDT effect with very low dose radiation, which makes it possible to damage cancer cells. Our strategy may offer a paradigm-shifting treatment alternative for TNBC patients who need neoadjuvant radiotherapy but wish to avoid long term detrimental effect on functional outcome by undergoing X-PDT using only a fraction of the conventional radiotherapy.
Citation Format: Biyao Yang, Rui Sang, Yi Li, Ewa Goldys, Wei Deng. Liposome platform enables X-ray induced photodynamic therapy treatment against human triple negative breast cancer cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 5743.</jats:p
Linked collectors and determiners for: Captura de datos de la Colección de Curculionoidea (Insecta: Coleoptera) de la Universidad Autónoma de Querétaro.
Natural history specimen data linked to collectors and determiners held within, "Captura de datos de la Colección de Curculionoidea (Insecta: Coleoptera) de la Universidad Autónoma de Querétaro". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/0b5f0f86-5743-4f04-a19e-d8e0a983e55a">https://bionomia.net/dataset/0b5f0f86-5743-4f04-a19e-d8e0a983e55a</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/0b5f0f86-5743-4f04-a19e-d8e0a983e55a">https://gbif.org/dataset/0b5f0f86-5743-4f04-a19e-d8e0a983e55a</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: Captura de datos de la Colección de Curculionoidea (Insecta: Coleoptera) de la Universidad Autónoma de Querétaro.
Natural history specimen data linked to collectors and determiners held within, "Captura de datos de la Colección de Curculionoidea (Insecta: Coleoptera) de la Universidad Autónoma de Querétaro". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/0b5f0f86-5743-4f04-a19e-d8e0a983e55a">https://bionomia.net/dataset/0b5f0f86-5743-4f04-a19e-d8e0a983e55a</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/0b5f0f86-5743-4f04-a19e-d8e0a983e55a">https://gbif.org/dataset/0b5f0f86-5743-4f04-a19e-d8e0a983e55a</a>. Formatted as a Frictionless Data package
Block Card 5743 St. Clement Court
This image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Cape Cod Style | 5743 St. Clement Court (Toledo, Ohio) | Dwelling | St. Clement Court (Toledo, Ohio) | Trilby Area (Toledo, Ohio)
Going Beyond Counting First Authors in Author Co-citation Analysis
The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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