1,724,156 research outputs found
Block Card 5458 Asta Court
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Cape Cod Style | 5458 Asta Court (Toledo, Ohio) | Dwelling | Evergreen Place Addition (Toledo, Ohio) | Wernerts Corners (Toledo, Ohio) | Trilby Area (Toledo, Ohio)
Efficacy, metabolism and pharmacokinetics of Ro 15-5458, a forgotten schistosomicidal 9-acridanone hydrazone
Full text linkTreatment of schistosomiasis, a neglected disease, relies on just one partially effective drug, praziquantel. We revisited the 9-acridanone hydrazone, Ro 15-5458, a largely forgotten antischistosomal lead compound.; Ro 15-5458 was evaluated in juvenile and adult Schistosoma mansoni-infected mice. We studied dose-response, hepatic shift and stage specificity. The metabolic stability of Ro 15-5458 was measured in the presence of human and mouse liver microsomes, and human hepatocytes; the latter also served to identify metabolites. Pharmacokinetic parameters were measured in naive mice. The efficacy of Ro 15-5458 was also assessed in S. haematobium-infected hamsters and S. japonicum-infected mice.; Ro 15-5458 had single-dose ED50 values of 15 and 5.3 mg/kg in mice harbouring juvenile and adult S. mansoni infections, respectively. An ED50 value of 17 mg/kg was measured in S. haematobium-infected hamsters; however, the compound was inactive at up to 100 mg/kg in S. japonicum-infected mice. The drug-induced hepatic shift occurred between 48 and 66 h post treatment. A single oral dose of 50 mg/kg of Ro 15-5458 had high activity against all tested S. mansoni stages (1-, 7-, 14-, 21- and 49-day-old). In vitro, human hepatocytes produced N-desethyl and glucuronide metabolites; otherwise Ro 15-5458 was metabolically stable in the presence of microsomes or whole hepatocytes. The maximum plasma concentration was approximately 8.13 μg/mL 3 h after a 50 mg/kg oral dose and the half-life was approximately 4.9 h.; Ro 15-5458 has high activity against S. mansoni and S. haematobium, yet lacks activity against S. japonicum, which is striking. This will require further investigation, as a broad-spectrum antischistosomal drug is desirable
Linked collectors and determiners for: R-Fungi - Herbário do Museu Nacional.
No full textNatural history specimen data linked to collectors and determiners held within, "R-Fungi - Herbário do Museu Nacional". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/a08cd2a4-5458-4d08-a820-23db24e2219d">https://bionomia.net/dataset/a08cd2a4-5458-4d08-a820-23db24e2219d</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/a08cd2a4-5458-4d08-a820-23db24e2219d">https://gbif.org/dataset/a08cd2a4-5458-4d08-a820-23db24e2219d</a>. Formatted as a Frictionless Data package
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
تغيرات البنيان الدقيق بالمجهر الإلكتروني الماسح لسطح الأهاب في ديدان شيستوسوما مانسوني البالغة بعد العلاج بعقاري برازيكوانتل و رو-15(5458)
No full textIn view of the known relationship between changes in the tegumental surface of schistosomes and the potency of antischistosomal drugs,
the present work is done to study the effect of two oral drugs, namely Praziquantel and Ro-15 (5458), on the tegument of Schistosoma mansoni by scanning electron microscopy. The damage produced in the tegument of both male and female worms after treatment with the curative and subcurative doses of Praziquantel and Ro-15 (5458) are described. A pronounced deformation of the whole worms was detected after the treatment with a combined reduced dose of the two oral antibilharzial drugs. The potency of the new compound Ro-15 (5458) is encouraging and deserves further studies to be recommended as an antischistosomal drug, particularly in those cases which may show evidence of drug resistance to Praziquantel.تتضمن الدراسة الحالية متابعة تأثير عقارين مضادين لديدان البلهارسيا شيستوسومامانسوني باستخدام الميكروسكوب الالكتروني الماسح . وهذان العقاران هما البرازيكوانتل وعقار جديد هو رو-15 (5458) .
وقد وصفت التغيرات التي تظهر على السطح الخارجي للديدان الناتجة عن استخدام الجرعات الشافية والتحت شافية لكل من العقارين ، كما وصفت أيضاً تشوهات الديدان الناجمة عن استخدام جرعة مركبة من كلا العقارين .
وقد أوضحت الدراسة كفاءة عقار رو-15(5458) الجديد ، في تأثيره على ديدان البلهارسيا المعوية بصورة مشجعة على مواصلة دراسته وإِمكانية استخدامه ، في حالات المرضى الذين يظهرون دلائل على مقاومة الطفيليات للعلاج بعقار برازيكوانتل
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
- …
