1,724,098 research outputs found
Pharmaceutical development of the novel metal-based anticancer agents NAMI-A and AP 5280
Get PDFThe pharmaceutical development of the two novel metal-based anticancer agents NAMI-A and AP 5280 is described in this thesis, starting with the development of analytical methods for the quality control of drug substance and final product, via the formulation process leading to a stable, intravenous administration form, and ending with the stability and compatibility studies of the infusion solutions. This research could also serve as the basis for the pharmaceutical development of other novel, metal-based anticancer agents. Because many metals exchange ligands easily, the compounds will usually not be stable in solution, necessitating preparation of a lyophilized product. NAMI-A and AP 5280 are examples of this. The experiments described in this thesis enabled the clinical evaluation of NAMI-A and AP 5280. At this time, 23 patients have been treated with NAMI-A and 30 with AP 5280 in the clinical Phase I study. Subsequent Phase II studies will provide insight into the clinical efficacy of these agent
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
A BACKBONE ORGANIZATION FOR DENVER BASED ENVIRONMENTAL JUSTICE ORGANIZATIONS 5280 FOR ENVIRONMENTAL JUSTICE
Get PDFEnvironmental injustices in Denver follow the same patterns that are seen throughout the country, which is that low-income People of Color are, relative to White people, disproportionately impacted by poor air and water quality, food deserts, displacement, and a phenomenon known as urban heat islands. The literature review conducted for this proposal revealed that despite the 2019 U.S Census Bureau indicating that Denver is 80.9 percent White, 29 percent Latino, and 10 percent Black, neighborhoods with predominantly Black and Latino residents are the neighborhoods experiencing environmental injustices in Denver.
For this project proposal, a literature review was conducted along with interviews with three Denver-based environmental organizations and one backbone organization based out of Boulder. Interwoven into this project design are also observations that the author has made as the result of being born and raised in Denver, the author’s experiences completing a field placement with the backbone organization that was consulted with for this project, and observations made by the author while working in two of the neighborhoods that have been indicated as being at high risk for becoming urban heat islands.
Denver has numerous environmental organizations with individual mission statements, but ultimately these organizations want Denver to be an environmentally healthy city for its current residents and future generations. In the nonprofit sector, both throughout the country and in Denver, individual organizations often work on large-scale systemic issues and then report on their progress as individual entities. Collective impact represents a paradigm shift for the nonprofit sector’s traditionally more individualistic approach to solving problems. A collective impact initiative brings partners from multiple sectors together to solve large scale systemic issues, such as environmental justice issues. Brining partners from multiple sectors together is critical because systemic problems are the result of multiple sectors. A collective impact initiative brings key actors and their expertise together to solve the problem at hand.
This project proposal concerns the creation of an organization called 5280 for Environmental Justice (5280 EJ), which is a backbone organization, designed to support a collective impact initiative in Denver whose mission would be to end environmental injustices in Denver. 5280 EJ will work as the nervous system that supports and brings together partners from multiple sectors to mobilize and advocate for systemic change in order to put an end to Denver’s environmental racism
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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